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14 Cards in this Set
- Front
- Back
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Cytidine triphosphate
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Converts phophatidate to phopholipids
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Phospholipids
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Phophatidylinositol (ring), phosphatidylcholine (long chain), phophatidylserine (amine/COO group) and Phophatidylethanolamine (no COO group)
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Cardiolipin
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Only phopholipid that generates an immune response
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Dipalmitoylphophatidylcholine
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Major component of lung surfactant
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Phopholipases
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Break down and remodel phospholipids
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Phopholipase A2
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Cleaves arachindonic acid in membrane phospholipids
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Plasmalogen
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An unsaturated alkyl group with Phosphatidylethanolamine in nervous tissue, Pcholine in heart
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Tay Sachs
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Deficiency in hexosaminidase and buildup of GM2 Gangliosides; present with cherry-red macula
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Gaucher Disease
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Deficiency in glucoeribrosidase and buildup of glucocerebrosides; present with haptosplenomegaly and osteoporosis
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Fabry disease
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Deficiency in alpha galactosidase A and buildup of globosides; present with kidney and heart failure
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Neimann Pick
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Deficiency in sphingomyelinase with a buildup of sphingomyelin; Present with nuerodgenerative course
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HMG-CoA Reductase
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Converts HMG-CoA to Mevalonate and eventually cholesterol
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HMG-CoA Reductase activation
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Insulin activates HMG-CoA Reductase phosphotase which activates HMG-CoA reductase
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Bile acid synthesis
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7 Alpha hydroxylase is rate limiting step of BA formation; controlled by feedback inhibition and requires TH and Vitamin C for activation
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