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1144 Cards in this Set

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Pleural Effusions
(2)
Malignant
Pneumo
Secondary medical Tx for chronic stable angina after first 5 (2)
1) If bp room add CCB
2) If refractory add Ranolazine
Dx Irregularly irregular rhythm, with no P waves
Afib
Who should get coronary angiography?
1) Lifestyle limiting angina despite medical tx
2) Markedly positive results on non-invasive stress testing
3) hx of Vtach
4) hx of Non specific CP with recurrent hospitalizations
Who should get coronary Ca testing?
Intermediate risk group (10-20% framingham risk score)
Dx short PR and delta wave
Wolf Parkinson White
(n.b. can become either orthodromic or antidromic AVRT)
Dx Wide QRS tachycardia in setting of known hx of ischemic damage
VTach
Tx for Left NSTEMI
Beta blocker
Dx New murmur and respiratory after recent MI (2). Dx study? Tx?
1) Acute MR
2) VSD
Dx study is Echo
Tx is IABP
Dx STEMI, respiratory distress, hypotension, new systolic murmur, and thrill.
Ventricular Septal defect
Dx 1-4 days after MI, heart failure, tamponade or pulseless electrical activity.
Ventricular free wall rupture
Dx Afib or Aflutter spurts between a baseline of bradycardia
Tachy-brady (a type of sick sinus sx)
Dx Baseline bradycaria with dropped beats
Sick sinus sx (sinoatrial node dysfunction)
Dx Drug induced heart block
Donepezil (ACh esterase inhibitor) causes increased vagal tone, bradycardia, and AV block
Tx for Hemodynamically unstable patients with arrhythmia
Electrical cardioversion
Dx study for Aflutter or AVNRT
Adenosine bolus
Dx study for Sinus tachycardia
Find underlying cause (e.g. TSH)
What is the CHADS2 risk score?
CHF
HTN
Age >75 years
Diabetes
Stroke or TIA (2 points)
-3 or greater get chronic anti-coagulation tx (warfarin)
*1-2 consider ASA vs warfarin
Tx chronic Afib
Beta blocker (or rhythm control e.g. verapamil) and Warfarin
Dx study and tx for asymptomatic PVCs
No studies or therapy needed
Tx for symptomatic PVCs
Beta blocker or CCB (e.g. verapamil)
Indication for ICD in CHF
EF less than 35%
Indications for pacemaker
1) Sick Sinus
2) symptomatic bradycardia due to 2nd or 3rd degree AV block
Tx for Cardiac arrest (Ventricular arrhythmias)
Medical management
1) ASA
2) Beta blocker
3) Statin
4) Plavix
5) ACE-I
Dx Recurrent syncope with cardiac arrest with family history of sudden death
Long QT syndrome
(cardiac arrest is in form of torsade de pointe)
Indication for Digoxin tx
Class III or IV heart failure (has no improved mortality, just keeps people out of hospital and makes them feel better)
Dx Dyspnea, S3 or S4, displaced apical impulse, and EF less than 45% after delivery
Peripartum cardiomyopathy
Dx study for new onset CHF (DOE or orthopnea or edema) in the setting of angina (including stable) +/-abnormal EF
Coronary angiography
Dx study for New onset CHF
Echo
Tx for Class I or II CHF (2)
(even if asymptomatic)
1) ACE-I
2) Beta blocker
3) Amlodipine only if refactory sx on 1 and 2
Suitable substitute for spironolactone in Class III or IV CHF (bc they got gynecomastia)
Epleronone
Tx for Class III or IV CHF
1) ACE-I
2) Beta blocker
3) Spironolactone
Dx Aortic regurg in pt with prosthetic valve
Prosthetic valve failure
Dx split S2, right ventricular heave
Atrial septal defect
Dx opening snap, low pitched middiastolic murmur best heard over mitral valve
Mitral stenosis
Dx and Tx for Short, soft (less than 3), midsystolic murmur in elderly patient
Usually aortic stenosis. No management needed.
Diagnostic criteria for DM
1) HbA1C greater than 6.5
2) Fasting glucose over 125
3) Random glucose over 200
4) 2 hour glucose tolerance test over 200
All of these have to be done twice except random BG with signs of hyperglycemia
Tx Prediabetes
Lifestyle modifications
Dx chronic pancreatitis with diabetes
Secondary diabetes
Tx Initial for T2DM
Metformin (and lifestyle modification)
Tx Inpatient for controlling hyperglyecemia
Long acting insulin with rapid acting insulin before meals (ISS)
Tx for proliferative diabetic retinopathy or macular edema
Laser photocoagulation
Tx for chronic hypogycemia in DM
Long acting and rapid acting prandial insulin
Dx BG over 250, anion gap acidosis (less than 7.3), bicarb less than 15, and positive serum or urine ketones.
Diabetic ketoacidosis (DKA)
Dx BG over 600, ph more than 7.3, bicarb more than 15, serum osmolality greater than 320, and absent urine or serum ketones.
Hyperglycemic hyperosmolar non-ketosis (HHNK)
Tx HHNK
IV fluids and identifying underlying cause
Tx DKA
Insulin drip
Dx soft, non-tender, non-pruritic plaques on eyelids
Xanthelasma (see in familial dyslipidemia)
Tx for Isolated low HDL
Lifestyle changes:
1) Exercise
2) Smoking cessation
3) Weight loss
LDL goal for 0 or 1 CV risk factor
Less than 160
LDL goal for a diabetic
Less than 100
(diabetes is a CVD equivalent)
LDL goal for pts with hx of CVA or TIA
Less than 100
Mgmt for hypothyroidism
Treat - Levothyroxine
Hashimoto disease is the most common cause of hypothyroidism, confirmation via TPO antibody unnecessary.
Mgmt of Thyroid nodule
If greater than 1 cm --> biopsy
If less than 1 cm, biopsy only if cancer risk hx
Mgmt of Hypothyroidism in pregnacny
Monitor, bc Thyroxine requirements go up 30-50%, want T4 1.5 normal
Tx for Grave's disease
Methimazole and Beta blocker
(better than radiation bc can achieve euthyroid. Also better than PTU)
Mgmt of new Hyper or Hypothyroid post partum
Recheck TSH and T4 to diagnose Postpartum Thyroiditis
Mgmt abnormal thyroid studies in the setting of acute illness
Recheck TSH and T4 to diagnose Euthyroid Sick Syndrome
Mgmt of incidentally discovered adrenal adenoma in asymptomatic patient
Get plasma-free metanephrine levels and overnight dexamethasone suppression test
(want to rule out hypersecretion of glucocorticoids and catecholamines)
Dx study for Resistant HTN and hypokalemia
Serum aldosterone to plasma renin activity ratio to diagnose Primary Hyperaldosteronism
Dx study for High dose dexamethasone sensitive elevated ACTH
MRI of pituitary
Dx ACTH dependent hypercortisolism
1) High dose dexamethasone resistant
2) High dose dexamethasone sensitive
1) Ectopic ACTH tumor
2) Pituitary tumor
Mgmt of Palpitations, sweating, HA, HTN
Abdominal CT scan to confirm Dx of Pheochyromocytoma
Dx low ACTH, low cortisol, and high glucocorticoids in setting of exogenous corticosteroids
Adrenal insufficiency due to exogenous corticosteroids
Tx for Pts with adrenal insufficiency in setting of stress (as from illness or surgery)
Stress level doses of corticostreroids (Hydrocortisone or Dexamethasone)
Tx for Osteoporosis
Vitamin D, Ca supplementation, Bisphosponates (or zoledronate annually if cannot tolerate bisphosphonates)
When and with what to screen for osteoperosis
Screen with DEXA in women over 65 or women 60-65 with increased risk of osteoperosis (i.e. weight below 154 lbs)
Tx for Osteoporosis prevention
Vit D and Ca
Bone mineral density T score cutoffs for Osteopenia and Osteoperosis
Osteopenia: -1 to -2.5
Osteoperosis: -2.5 or more
Dx unilateral flank pain, n/v, gross or microscopic hematuria
Nephrolithiasis
Dx study for Nephrolithiasis
Helical abdominal CT scan
Dx study for Acute abdominal pain
Supine and upright abdominal radiographs (to look for air fluid level --> bowel obstruciton, and free peritoneal air --> perforated bowel)
Dx Abdominal pain, back pain, syncope
Abdominal aortic aneurysm
Dx Recurrent abdominal pain or discomfort, relieved with defecation, with diarrhea
Irritable Bowel Syndrome
Tx for Irritable bowel syndrome
Fiber and/or polyethylene glycol with reassurance
Dx crampy abdominal pain, with bloody stool, in eledery atherosclerotic patients
Ischemic colitis
Mgmt LLQ pain, fever, leukocytosis
Contrast enhanced CT scan to confirm Diverticulitis
Mgmt Chronic upper abdominal pain radiating to back, diabetes, steatorrhea, pancreatic calcifications
Abdominal CT to look for pancreatic calcifications to confirm Chronic Pancreatitis
Dx Thrombotic microangiopathy (schistocytes, elevated retic count, elevated LDH) and Thrombocytopenia
Hemolytic Uremic Syndrome
Dx Diarrhea and tenesmus within 6 weeks of radiation therapy
Radiation proctitis
Dx mid-epigastric abdominal pain, postprandial diarrhea, +/-DM
Chronic pancreatitis
Alarm criteria in IBS
1) Fever
2) Weight loss
3) Blood in stool
4) Abnormal PE
5) FHx of IBD or Colon ca
6 Pain or diarrhea that interferes with sleep
Dx 10-15 stool/day, lower abdominal pain, cramping, fever, leukocytosis in setting of Abx
C Diff
Tx for Salmonella gastroenteritis
Self limiting, no tx
Dx Anti-mitochondrial Ab
Primary Biliary Cirrhosis
Tx for Primary Billiary cirrhosis
Ursodeoxycholic acid
Which liver disease is associated with UC and Crohn's
Primary sclerosing cholangitis
Beading of the biliary duct
PSC
Pattern of bilirubin elevation
1) Prehepatic
2) Intrahepatic
3) Posthepatic
1) Prehepatic - Unconjugated hi
2) Intrahepatic - Both hi
3) Posthepatic - Conjugated hi
Dx Unconjugated hyperbilirubinemia with normal Hgb levels and otherwise normal LFTs
Gilbert Syndrome
Tx for Symptomatic gallstone disease
Cholecystectomy
Dx Elevated bilirubin and alkphos with IBD
PSC
Dx fever, jaundice, RUQ pain and common bile duct obstruction
Acute cholangitis
Dx biliary colic, Murphy sign, fever, leukocytosis, mild biliruibin and AST/ALT elevation, thickened gallbladder wall.
Acute cholesystitis
Tx for Gallstone pancreatitis
ERCP with sphincterotomy and stone extraction
Dx epigastric pain radiating to back, n/v, fever, tachycardia, abdominal distension, hypoactive bowel sounds.
Acute pancreatitis
Dx Stones in gallbladder, dilated bile duct, and elevated AST/ALT with acute pancreatitis.
Acute pancreatitis due to gallstones
Tx for Severe acute pancreatitis
Enteral nutrition with nasojejunal feeding tube
Mgmt GERD sx with dysphagia
Upper endoscopy
(Dysphagia is an alarm sx)
Tx Erosive Esophagitis
PPI
Dx study for gastric ulcer
Biopsy
(all ulcers should be biopsied for possible malignancy)
Mgmt of dyspepsia with NSAIDs
Stop the NSAID
Tx for Functional dyspepsia
PPI
(i.e. dyspepsia/gastritis without visible organic pathology)
Dx study for GI Bleed of unknown etiology after endoscopy and colonoscopy
Repeat upper endoscopy
Dx LLQ pain, urgent defecation, red or maroon rectal bleeding not requiring transfusion usually in older people
Colonic ischemia
Mgmt of Upper GI bleed after fluid resuscitation
Upper endoscopy for Diagnosis, Prognosis, and possible therapy
Tx for GI bleeding in hemodynamically unstable patients
Fluid resuscitation
Dx Painless lower GI bleeding
Diverticulosis and vascular ectasia
Dx BRBPR and pain with defecation
Anal fissure
Screening for chronic Hep B infection
Liver ultrasound to look for hepatocellular ca
Dx Acute hepatitis, fatigue, n/v, jaundice, AST/ALTs over 1000.
Hepatitis A
Dx AST;ALT ratio greater than 2, elevated alk phos
Alcoholic hepatitis
Dx Elevated AST/ALTs, hi GGT, mild bilirubinemia, mildly elevated alk phos, present of auto antibodies.
Autoimmune hepatitis
Dx Positive HBsAg and Anti-HBc IgM
Acute HepB
(The IgM tells you its acute and not chronic infxn)
Dx anti-hepatitis C Ab
Exposure to Hep C or vaccine
Dx Cirrhosis, obesity, T2DM, and hyperlipidemia
Non-Alcoholic Steatohepatitis
NASH
Dx UC and marked elevation in alk phos
PSC
Dx Ascitic fluid analysis showing serum to ascites albumin gradient greater than 1.1
Portal hypertension
(caused by Liver disease, such as cirrhosis, right sided HF (congestive hepatopathy), or Budd-Chiari)
Tx for Hepatic Encephalopathy
Lactulose
Dx kidney dysfunction in setting of portal htn after exclusion of prerenal azotemia, intra renal disease, and renal obstruction.
Hepatorenal syndrome
Dx small, exquisitely tender nodules on shins in IBD
Erythema nodosum
Dx Contiguous inflammation of rectum proximally
UC (Ulcerative colitis)
Tx for Ulcerative colitis
Mesalamine
Dx Chronic watery diarrhea without bleeding without findings on colonoscopy
Microscopic colitis
Which test characteristics are robust or sensitive to prevalence.
Robust - Sensitivity, Specificity, LR
Sensitive - PPV,. NPV
What is the relationship between LRs and Post Test Probability
LRs of 2, 5, and 10 increase Post test probability 15, 30, and 45% respectively
Screening recommendation for AAA
All men 65-75 who have ever smoked
Flu vaccine recommendations for COPD
All COPD patients regardless of age
Pneumovax recommendations
1) Anyone over 65
2) Smokers, COPD, or asthma can be younger
3) RE-Vaccination in everyone over 65 if last vaccination was more than 5 years ago AND before 65.
4) RE-Vaccination in immunosuppressed people if first vaccine more than 5 years ago
What is the best end point for any trial?
Mortality
Zoster vaccine recommendations
All patients over 60 regardless of prior varicella/zoster hx
HPV vaccine recommendations
All women 9-26
Colon Ca screening recommendations
Starting at age 50
1) Colonoscopy every 10 years
2) Flex sig every 5 years with home FOBT every 3 years
3) Annual home FOBT
Dx Syncope in ischemic HF
VTach
How to diagnose orthostatic hypotension
Drop in systolic BP of 20 or 10 diastolic after 3 minutes of standing
Dx Syncope, nausea, lightheadedness, diaphoresis
Vasovagal syncope (situational)
Dx LOC irrespective of body position without preceding symptoms
Cardiac arrhythmia
Dx study for infrequent syncope
Implantable loop recorder
Tx for Depression after failing 1 antidepressant
A different antidepressant
Tx for Depressive sx of 2 weeks more than 8 weeks after death of loved one
Pharmacologic antidepressants
Tx for Acute cocaine intoxication
Benzodiazepine
Tx for short term alcohol dependence
Naltrexone
Tx for Acute opioid intoxication
Naloxone (narcan)
Tx for Spinal stenosis with neurologic deficits and pain refractory to NSAIDs and PT
Surgery
Dx study for Vertebral osteomyelitis
MRI
Tx for Acute non-specific low back pain
NSAIDs or Acetaminophen
Dx Back pain, muscle weakness, and bowel or bladder incontinence
Spinal cord compression
Dx study for Spinal cord compression
MRI of spine
Mgmt Cough variant asthma
Albuterol inhaler trial for tx and dx
Mgmt for Chronic cough in non-smoker
Antihistamine/decongestant combination
2 Most common causes of hemoptysis
1) Bronchitis
2) Malignancy
Dx study for Hemoptysis with and without alarms for malignancy
1) CXR
2) If over 40, or more than 1 week, or 40 pyhx than Chest CT
Tx Acute bronchitis
Symptom management
Effects of smoking cessation on lung function (2)
1) Absolute improvement (minor)
2) Decreased rate of decline (major)
Tx for Smoking cessation
Varenicline
(Bupropion and nortriptyline effective but less so)
Indications for bariatric surgery
1) BMI over 40 regardless of comorbidities
2) BMI over 35 w/ comorbidities
When drug therapy was unsuccessful
Tx for Obesity after diet and exercise fail
Orlistat
Dx Nausea and vomiting within months of bariatric surgery
Stomal stenosis
Mgmt Unintentional weight loss with negative labs and imaging
Recheck in 6 months
(risk of ca low)
Most common cause of unintentional weight loss in ca negative patients
Depression
Medication that can cause weight loss
Bupropion
Dx Unintentional weight loss, skeletal muscle dysfunction, osteoperosis, depression
COPD
Tx for Menorhagia
Medroxyprogesterone for 10-21 days
(Menoroghia is heavy menstrual bleeding)
Dx Oligomenorrhea, hirsutism, acne, alopecia
PCOS
Tx for Menopausal sx
Estrogen replacement therapy
Dx study for Amenorrhea after pregnancy rule out
FSH, TSH, and Prolactin levels
Dx study for Abnormal uterine bleeding in patients over 35
Endometrial biopsy
Dx Well-demarcated, rapidly spreading area of warmth, swelling, tenderness, and erythema +/- fever
Cellulitis
Dx Erythematous, dry or greasy scales and crusts
Seborrheic dermatitis
Dx Light pink to red papules and thin plaques with scaling, active borders and central clearing
Tinea
Dx Erythematous macules and plaques that progress to epidermal necrosis and sloughing on less than 10% of body
Steven Johnson
Dx Targetoid lesions of both skin and mucosal surfaces
Erythema multiforme
Tx for Zoster reactivation
Oral antiviral if within 72 hours of onset of rash
Dx Erythema, telangiectasias, papules, pustules, and sebaceous hyperlasia of the face and nasolabial folds
Rosacea
Dx brown to black, well demarcated, stuck on papules
Seborrheic keratoses
Tx Extensive or inflammatory acne
Oral abx
Dx Rapid appearance of wheal lasting less than 24 hrs
Acute uriticaria
Mgmt Solitary, mobile, LAD of less than 2 cm
No mgmt needed
Mgmt Enlarging, firm, axillary LAD in woman over 40
Biopsy
Screening for hearing loss in elderly
Whispered voice test even if claiming asymptomatic
Dx study for Fall in elderly patient
Get up and go test
Tx Urge urinary incontinence
Tolterodine or Oxybutynin
Mgmt of Non-specific dizziness in eldery patient
PT
Initial Tx for Stage I HTN
Lifestyle modification for 6 to 12 months
(then you go to HCTZ)
Initial Tx for HTN in eldergy pt
HCTZ (more salt sensitive)
BP Goal in diabetics or CKD
130/80
Dx HTN, radial to femoral artery delay, rib notching
Coarctation of Aorta
Initial Tx for Stage II HTN
2 drugs, usually HCTZ and ACE-I
Dx Serum ferritin levels lower than 100-120
Iron deficiency anemia
Dx Pancytopenia, low retic count, hypoplastic bone marrow (usually with fat)
Aplastic anemia
Tx Iron deficiency anemia
Ferrous sulfate
Dx bite or blister cells
G6PDase Deficiency
Dx Low MCV and target cells with normal iron studies
Thalassemia minor
Dx Macrocytic anemia, thrombocytopenia, elevated LDH
Vitamin B12 deficiency
Dx study for suspected Vit B12 deficiency with low normal Vit B12
Methylmalonic acid and homocysteine
Dx Elevated LDH, decreased serum haptoglobin, and elevated retic count
Hemolytic anemia
Dx Hemolytic anemia, schistocytes, in setting of prosthetic valve
Prosthetic valve hemolytic anemia
Dx Microcytic anemia, hypochromia, variable size, and variable shape
Iron deficiency anemia
Dx Spherocytes on blood smear
Warm antibody-mediated hemolytic anemia
Dx Long PT and PTT, high D-dimer, low serum fibrinogen and platelets, and microangiopathic hemolytic anemia
Disseminated intravascular coagulation
Dx Long bleeding time, borderline PTT, low factor VIII wit FHx of coagulopathy
Von Willebrand
Dx Transient aplastic crisis in patients with chronic hemolytic anemia (e.g. sickle cell disease)
Parvovirus
Dx Right sided heart failure in sickle cell anemia
Pulmonary HTN
(common in sickle cell anemia)
Tx Acute chest syndrome in sickle cell anemia
Transfusion
Dx study Osteonecrosis
MRI of the hip
Dx study for Sickle cell anemia
Blood smear
Dx Decreased platelets, thrombotic event in setting of recent heparin
Heparin induced thrombocytopenia and thrombosis
Dx Microangiopathic hemolytic anemia, thrombocytopenia with normal coagulation, CNS sx, renal failure, fever
Thrombotic thrombocytopenic purpura
Dx Large platelet clumps on stained blood film
Pseudothrombocytopenia
Tx for Immune thrombocytopenic purpura
Corticosteroids
Tx for Antiphospholipid syndrome after thrombus
Warfarin for life
Dx Lupus anti-coagulant or anticardiolipin or B2 glycoprotein antibodies
Antiphospholipid
Dx decreased AG with anemia, proteinuria, hypercalcemia, and renal failure
Multiple myeloma
Dx hypercalcemia, osteopenia, anemia, leukopenia, and renal insufficiency
Multiple myeloma
Dx M spike less than 3.0 with less than 10% plasma cells in bone marrow
Monoclonal gammopathy of unknown significance
Auer Rods
AML
Dx BCR/ABL oncogene, granulocytes with left shift, and myeloid proliferation in bone marrow
CML
Dx Blanching rythematous macules around wrists and ankles after tick exposure
Rock mountain spotted fever
Dx Very high or brief fever spikes and rapid defervescence without chills
Factitious fever
Dx Fever after inhaled anesthetics and depolarizing muscle relaxants
Malignant hyperthermia
Tx for Sepsis with hemodynamic instability
Fluids
Flu vaccine recommendations for COPD
Annually regardless of age for everyone with COPD
Dx Low MCV, low serum Fe, elevated TIBC, and low transferrin saturation
Iron deficiency anemia
Tx Rocky Mountain Spotted Fever
Doxycycline
Indication for Norepinephrine in septic shock
If MAP is less than 65 after fluid resuscitation
Criteria for Sepsis
1) Positive BCx or visible infxn
2) Systemic response to infxn, at least 2: fever, tachycardia, tachypnea, leukocytosis
aka SIRS with positive BCx
Criteria for Systemic inflammatory response syndrome (SIRS)
At least 2 of:
Fever
HR over 90
Respiration greater than 20 (or PCO2 less than 32)
Leukocytosis (or Immature bands 10%)
Criteria for Septic shock
Sepsis with hypotension or evidence of perfusion abnormalities with adequate fluid resuscitation (or on vasopressors)
Severe complications of Group A Strep (3)
1) Peritonsillar abscess (quinsy)
2) Post-streptococcal glomerulonephritis
3) Rheumatic fever
Tx for Acute otitis media
Amoxicillin
(Amox-clav or Ceftriaxone if not improved within 3 days)
Centor Criteria for Strep Throat (4)
1) Fever
2) Tonsillar exudates
3) Tender LAD cervical
4) Absence of cough
Mgmt according to Centor Criteria
0-1 Nothing
2-3 Rapid strep antigen test
4 Empiric Abx tx
Mgmt for Asymptomatic UTI in pregnant woman
Ampicillin
Dx
Prostatitis refractory to Abx
Prostatic abscess
Tx
Asymptomatic UTI
No treatment
Dx
Fever, chills, sweats, n/v, diarrhea, and flank pain
Pyelonephritis
Tx
Pyeloneophritis in non-pregnant woman
Oral Fluoroquinolone
Tx
Recurrent UTI in healthy women
Trimethoprim sulfamethoxazole (bactrim) PRN for days with symptoms
Dx
Mucoprurulent discharge or bleeding of os
Cervicitis
Tx
Cervicitis
Ceftriaxone with doxy or azithromcyin
Dx
Arthritis, tenosynovitis, sparese peripheral necrotic pustulues
Gonorrhea
Dx
Fever, HA, and painful, ulcerated vesicular lesions on junk
Genital herpes
Tx
Pelvic inflammatory disease
Ceftriaxone and oral doxycycline
Dx
CD4 less than 200, fever, dry cough, dyspnea for several days or weeks
Pneumocystis jirovecii
Tx
Pneumocystis jirovecii
Bactrim
and Steroids if hypoxic
HIV Abx prophylaxis by CD4 count and PPD
1) Less than 200 - Bactrim for PJP and Toxo
2) Less than 50 - Azithromcyin for Mycobacterium Avium
3) PPD positive but lungs clear - Isoniazid
Dx study for
Acute HIV infxn
RNA viral load
Dx
Ring enhancing lessions on MRI, neurologic deficits, in setting of HIV
Toxoplasmosis
How to reduce ventilator associated PNA
Semi erect positioning of patient
Infectious precautions for C Diff
Barrier protection and soap and water
Precautions for Meningoccocal meningitis
Droplet precautions (surgical mask)
Precautions for TB
Airborne N95 mask
Mgmt for
Positive PPD
CXR
PPD cutoffs by risk (3)
5 mm Immunosuppressed or highest risk (close contact with TB)
10 mm Immigration form endemic country or prison worker
15 mm for healthy people
What must you get tested before starting a TNF-alpha inhibitor
TB tested with PPD (and treat if more than 5 mm)
Dx
Severe, progressive PNA during flu season
MRSA
Tx
Community acquired PNA
Azithromycin
Tx
PE from valve endocarditis (Right heart valve)
Vancomycin plus cefepime
Tx
Left sided native endocarditis
Penicillin plus gentamycin
or
Ceftriaxone plus gentamycin
Dx
Positive BCx, vegetation on Echo, and new valvular regurg
Endocarditis
Dx study for
Suspected Vertebral osteomyelitis
Spine MRI
Dx study for
Osteomyelitis
MRI
Dx study for
Confirmed Osteomyelitis
BCx or Bone culture
Pneumovax is indicated in everyone after their 65th birthday or after 65 if there have been more than 5 years since last vaccine
.
Dx
Severe, progressive PNA during flu season
MRSA
Tx
Community acquired PNA
Azithromycin
Tx
PE from valve endocarditis (Right heart valve)
Vancomycin plus cefepime
Tx
Left sided native endocarditis
Penicillin plus gentamycin
or
Ceftriaxone plus gentamycin
Dx
Positive BCx, vegetation on Echo, and new valvular regurg
Endocarditis
Dx study for
Suspected Vertebral osteomyelitis
Spine MRI
Dx study for
Osteomyelitis
MRI
Dx study for
Confirmed Osteomyelitis
BCx or Bone culture
Dx
Confusion and agitation in setting of chronic dementia with recent anesthesia
Postooperative delirium
Tx
Acute delirium inpatient
Haloperidol
Dx
Mental status changes, nystagmus, ophthalmoplegia, unsteady gait
Wernicke's encephalopathy
Tx
Wernicke's encephalopathy
Thiamine
Dx
Smudge cells
CML
Dx
Proteinuria during day but not over night
Orthostatic proteinuria
Dx
AKI with sterile pyuria (PMNs in urine) and WBC casts
AIN
Dx study for
Persistent hematuria of non glomerular origin
Cytoscopy
Dx
Muscle pain, weakness, dark urine, elevated serum creatine kinase
Rhabdomyolysis
Dx
AKI, thrombocytopenia, microangiopathic hemolytic anemia
Hemolytic uremic syndrome
Dx
Muddy brown casts in setting of drugs or prolonged renal ischemia
ATN
Tx for
Diabetic nephropathy
ACE-Is or ARBs
Indications for dialysis in CKD (4)
1) Hypervolemic
2) Hyperkalemic
3) Acidemic
4) Uremic
Dx
Proteinuria, HTN, and decreasing GFR
Diabetic nephropathy
Dx study for
AKI with suprapubic tenderness
Renal US
Dx study for
Non diabetic nephropahty (hematuria) in a diabetic
Renal biopsy
Dx
Bone disease, elevated PTH, hypocalcemic, and hyperphosphatemic
Bone disease 2/2 hyperparathyroidism in CKD
What does the Urine anion gap (UAG) tell you? (3)
If negative - Extra renal metabolic acidosis
If positive (30-50) - Normal
If positive in setting of metabolic acidosis - RTA
Formula for Serum osmolality
= Na*2 + BUN/2.8 + gluc/18
Dx
Hypokalemia with low urine K
Extra renal losses of K (laxatives or diarrhea)
Dx
Hypocalcemia in setting of acute pancreatitis
Free fatty acid chelation of Ca
Tx for
Hypercalcemia in Sarcoidosis
Corticosteroids (prednisone)
(decrease macrophages which produce 1alpha-hydroxylase which increases vit D)
Most common cause of hypercalcemia outpatient
Hyperparathyroidism
Dx
Severe muscle weakness following glucose therapy in alcoholic
Hypophosphatemia
(Insulin release from glucose moves phosphate into cells which is low bc of low oral intake)
Risk for demented patients during surgery
General anesthesia
Tx for
Delirium inpatient
Haloperidol
Dx
MS changes, ophthalmoplegia, nystagmus and unsteady gait
Wernicke's encephalopathy
Cause of wenicke's encephalopathy
Thiamine deficiency
Dx
Neurologic sx including vision loss, hallucinations, numbness, tingling, weakness or confusion prior to HA
Migraine with aura
Dx
Dull, bilateral, diffuse headache described as squeezing
Tension type headache
Dx study
For sudden worst HA of life
Non contrast Head CT
Tx for
Migraine prophylaxis
(indication more than 2 per week)
Amitrptyine (TCAs), Beta blockers, CCBs, valproic acid, topirmarate
Abortive Tx for Migraine
Triptans (5-HT1 agonists), NSAIDs, Ergotamine
Dx
Prominent memory loss, anomia, impaired recognition of illness, variable degree of personality change
Alzheimers
Dx
Dementia of a few month onset with startle myoclonus
Creutzfeldt-Jakob
Dx
Parkinsonism, visual hallucinations, fluctuating symptoms, impaired learning and attention, less memory impairment
Dementia with Lewy bodies
Tx for
Mild Alzheimer's
Donepezil
(ACh esterase inhibitor)
Tx for
Moderate or advanced Alzheimer's
Memantine
Dx
Resting tremor, bradykinesia, rigidity, postural instability
Parkinson Disease
Dx
Tremor with voluntary movement that resolves with alcohol
Essential tremor
Tx for
Essential tremor
Propanolol
Dx
Meningitis with Gram positive bacilli in immunocompromised
Listeria monocytogenes
Dx
Fever, HA, myalgia, purpuric rash that begins on wrists and ankles and spreads centripetally
Rocky mountain spotted fever
Dx
Bacterial meningitis with Gram negative cocci
Nisseria meningitidis
Empiric Tx for bacterial meningitis in patients over 50
Ceftriaxone + Vancomycin + Ampicillin
Empiric Tx for bacterial meningitis in patients under 50
Ceftriaxone + Vancomycin
When should rehab begin after stroke?
Immediately
Tx for
Acute Stroke within 3 hrs of onset
tPA
Hold ASA until 24 hours after tPA
BP cutoffs to treat HTN in post ischemic stroke
Over 220/120
Dx study for
Sudden worst HA of life with negative non contrast Head CT
LP
Agent in Bell's palsy
HSV-1
Dx
Rapidly progressive Ascending extremity weakness, paresthesias, and areflexia.
Guillaain-Barre
Dx
Wrist pain sparing palm, numbness and tingling in the median nerve distribution, weakness of thenar muscles
Carpal tunnel
Dx
Stocking glove paresthesias or painful dysesthesias
Diabetic neuropathy
Positive Finkelstein test
de Quervain tenosynovitis
Dx study for
New small breast mass on mammography
Ultrasound
Dx
Persistent, scaling, eczematous, ulcerated lesion on breast around nipple
Paget disease of breast
(indicates invasive or intraductal cancer)
Dx study for
New breast mass
Palpation, Mammography, and FNA
Tx for
Small focal breast cancer tumor (3)
Lumpectomy
Sentinel node dissection
Radiation
Colonoscopy screening for 1st degree relative
1) Starting at 40 or 10 years before relative
2) Every 5 years
Dx study for
Single positive FOBT in asymptomatic pt
Colonoscopy
Screening for colon ca in IBD
1) Starting 8 years after onset of disease
2) Every year
Dx screening for lung ca
None
Dx study for
Pulmonary nodule less than 4 mm in low risk population
No study necessary
Dx study for
Diagnosed lung cancer
Lymph node biopsy for staging
Tx for
Small cell lung cancer
Chemotherapy and radiation
(surgery is not effective)
Indications for prostate biopsy (2)
1) PSA over 4
2) Rising PSA
Tx for
Prostate ca
Leuprolide
Dx study for
Atypical pap smear results
Colposcopy with biopsy
HPV vaccination recommendations
Females and males 9-26
Pap screening recommendations
1) Start at 21 or 3 years after first sex
2) Annually for 21-30
3) Every 3 years after if normal in 30-65
Dx
Berry like lesion
Nodular melanoma
Hyperkeratotic precursor to squamous cell carcinoma
Actinic keratosis
Dx
Pink, pearly, nodules with telangiectasias
Basal Cell carcinoma
Dx
Rapidly progressive, crater like firm nodule
Keratoacanthoma
Tx for
Keratoacanthoma
Surgical excision
(can cause tissue damage or become malignant)
How to treat cancer pain
1) Non narcotics
2) Short acting narcotics
3) Then from that determine there long acting narcotic needs and Rx short acting for break through pain
Tx for
Dyspnea in hospice ca care
Opioids (short acting)
Definition of unstable angina
Angina is new, worsening, or occurring at rest
Antihypertensive for a diabetic patient with proteinuria
ACE-I
Dx
Hypotension, distant heart sounds, JVD
Cardiac tamponade
Drugs that slow AV node conduction (3)
1) Beta blockers
2) Digoxin
3) CCBs
HOCM murmur
Systolic ejection murmur along lateral sternal border that increases with Valsalva maneuver and standing
Murmur aortic insufficiency
Diastolic, decrescendo, high pitched, blowing murmur best heard when standing up
Murmur aortic stenosis
Systolic crescendo/decrescendo murmur that radiates to the neck, increases with increased preload
Murmur mitral regurg
Holosystolic murmur that radiates to the axilla or carotids
Murmur mitral stenosis
Diastolic, mild to late, low pitched rumble
Tx for
Afib or Aflutter
1) If unstable
2) If stable
1) If unstable - Cardiovert
2) If stable - Rate control with Beta blockers
Tx for
Vfib
Cardioversion
Autoimmune complication 2-4 weeks post MI
Dressler's syndrome: fever, pericarditis, elevated ESR
Tx for
IV drug use with JVD and holosystolic murmur at left sternal border
Treat existing HF and replace tricuspid valve
Dx study for
Hypertrophic cardiomyopathy
Echo
Dx
Fall in systolic BP greater than 10 mm with inspiration
Pulsus parodoxus --> Cardaic tamponade
Classic EKG findings in pericarditis (2)
1) Low voltage
2) Diffuse ST segment elevation
Indications for surgical repair of AAA
Greater than 5.5 cm
Rapidly enlarging
Symptomatic
or Ruptured
EKG findings in MI (3)
1) ST segment elevations
2) Flattened T waves
3) Q waves
Dx
Young patient with angina at rest, ST segment elevation, nl cardiac enzymes
Prinzmetal's angina
Dx
CHF, shock, altered MS
Silent MI
Agent that reverses effect of heparin
Protamine
Endocarditis prophylaxis
1) Dental
2) GI or GU surgery
1) Dental - Amoxicillin
2) GI or GU surgery - Ampicillin + Gentamicin
Most common cause of HTN in young women
OCPs
Most common cause of HTN in young men
EtOH
Asplenic patients are susceptible to these organisms
Encapsulated organisms
1) Strep pneumo
2) Nisseria meningitidis
3) H flu
4) Klebsiella
Number of bac needed on urine sample to think UTI
100,000
(100k)
Dx
Fever, malaise, cough, night sweats recent SW US travel.
Tx?
Dx - Cocciodomycosis
Tx - Amphotericin B
Dx
Blueberry muffin rash
Rubella
What should always be done before LP?
Check ICP with papilledema or head CT
Dx
Gamma globulins in CSF
Multiple sclerosis
Dx
Initial pruritic papule with LAD progresses to eschar in 7-10 days
Tx?
Dx - Cutaneous anthrax
Tx - Penicillin or Ciprofloxacin
Dx
Tabes Dorsalis, general paresis, gummas, argyll robertson pupils, aortitis, aortic root aneurysm
Tertiary syphilis
Dx
Arthralgia, migratory polyarthropathies, Bell's palsy, myocarditis
Secondary Lyme disease
Dx
Cold agglutinins
Mycoplasma
Tx for
Candidal thrush
Nystatin oral suppression
When and what to begin in HIV opportunistic prophylaxis
1) Less than 200 CD 4 count - Bactrim for Pneumocystis jiroveci
2) Less than 100 - Clarithromycin/Azithromycin for MAI
Dx
Alcoholic and smoker with lung sx with no gram stain but positive silver stain
Legionella pneumonia
Dx
Acute onset monoarticular joint pain, bilateral bell's palsy.
Tx?
Dx - Lyme disease
Tx - Doxycycline
Main organisms in endocarditis (2)
1) Stapy aureus
2) Strep epidermidis
Dx
Branching rods in oral infection
Actinomyces israelii
Dx
Painful chancroid
Haemophilus ducreyi
Dx
Dog or cat bite
Pasteurella
Dx
Infection in gardner
Sporothrix (sporotrichosis)
Dx
Infxn pregnant with pets
Toxoplasmosis
Dx
Meningitis in adults
Neisseria meningitidis
Dx
Meningitis in elderly
Strep pneumo
Dx
Alcoholic with pneumonia
Klebsiella
Dx
Currant Jelly sputum
Klebsiella
Dx
Infxn in burn victims
Pseudomonas
Dx
Osteomyelitis from foot wound puncture
Psuedomonas
Dx
Osteomyelitis in sickle cell patient
Salmonella
Dx
HTN with hypokalemia
1) If renin activity low
2) If renin activity high
1) If renin activity low - Primary Hyperaldosteronism
2) If renin activity high - Renovascular HTN (renal artery stenosis)
Dx
Purpura in elderly on back of hands
Tx?
Perivascular connective tissue atrophy
Tx - none
Dx
Palpable purpura, low complement levels, glomerulonephritis, arthralgias, hepatosplenomegaly,
Mixed Essential Cyroglobulinemia
Dx
Muscle weakness (extreme) that resolves with rest
Myasthenia gravis
Tx for
Benign essential tremor
Propanolol
Dx
Tremor with planned, voluntary movement only, family hx
Essential tremor
The 4 criteria of Nephrotic Sx
1) Proteinuria greater than 3 g/day
2) Hypoalbuminemia (less than 3.5)
3) Edema
4) HLD and lipiduria (waxy casts)
3)
What kind of state is nephrotic sx?
Hypercoagulable
Pharmacologic agents that shift K into cells in acute hyperkalemia
1) Insulin and glucose
2) Na bicarb
3) Beta 2 agonists
Dx
Nephrotic sx in Blacks with obesity, heroin, or HIV hx
Focal Segmental Glomerulosclerosis
Most common cause of nephrotic sx in adults
Membranous nephropathy
Most common cause of nephrotic sx in children
Minimal change disease
Dx
Lung and GI involvement in immunocompromised pt
CMV
Dx
Fever, hives, arthralgias, and LAD after infection (usually 7-10 days later)
Drug induced reaction (serum sickness)
Dx
New clubbing in COPD pt
Lung cancer
Dx
Recurrent pain, itching, and red steaks in arms in setting of weight loss
Trousseau's syndrome (migratory thrombophlebitis) caused by occult malignancy usually pancreatic or lung)
Dx
New HA, jaw pain, scalp pain, visual loss.
Temporal arteritis
Tx for
Temporal arteritis
High dose prednisone
(to prevent damage to retinal artery and other vessels)
Dx
Weakness, fatigue, hypotension, cold intolerance, brittle nails, bradycardia
Pituitary tumor causing secondary adrenocortical deficiency
Dx
Hyperpigmentation, amenorrhea in young adult
Congenital adrenal hyperplasia
Most common deficiency in Congential adrenal hyperplasia
21-hydroxylase deficiency
Dx study for
CP in young woman with no risk factors for CAD
None
Dx study for
Newly diagnosed Myasthenia gravis
Chest CT (to look for thymoma)
Tx for
Kidney stones in acidic urine
Potassium citrate
Dx
Palpable mass in RUQ with hyperbilirubinemia in child
Choledochal cyst
Tx for
Cocaine induced CP
Benzos
(also nitrates and aspirin)
Dx
Epigastric pain with voluminous pale foul smelling diarrhea
Chronic pancreatitis
Dx
EKG shows flat and broad T waves, PVCs
Hypokalemia
Dx
Fever, ns, LAD, arthralgias, diarrhea
Acute HIV
Dx
New onset diabetes, arthropathy, and hepatomegaly
Hemochromatosis
Dx
No pulses but telemetry shows beats
Pulseless electrical activity (PEA)
Tx for
PEA (pulseless electrical activity)
Chest compressions, ventilation with 100% oxygen
Door to therapy time for PCTA and fibrinolysis in MI
PTCA - 90 minutes
Fibrinolysis - 30 minutes
Most common cause of uncomplicated UTI in women
Ascending infection of urethra usually from sex (honeymoon cystitis)
Dx
Hazy lung fields, cough, dyspnea, fever, malaise in setting of farming or bird care
Hypersenstivity pneumonitis (bird fancier's lung or famer's lung)
Tx for
Hypersensitivity pneumonitis
Avoidance of antigen
Dx
Arthritis, lesions on shins, bloody diarrhea, P-ANCA positive
UC (IBD)
Ankylosing spondylitis and Ulcerative colitis share this HLA type
HLA-B27
Most common sites of thrombus for PE
1) Iliac
2) Femoral
3) Popliteal
Dx
Elevated alk phos and bowed legs on xray
Paget's disease
Dx
RUQ pain, mildly elevated liver enzymes, firm hepatomegaly.
Mets to the liver (usually from GI)
Dx
High fever, chills, tenosynovitis, migratory polyarthralgias and pustular lesions on extremities, negative BCx
Disseminated gonococcus
Dx
4th and 5th finger decreased sensation and weakened grip
Ulnar nerve syndrome
(medial elbow compression)
Dx
Heel pain, +/- shoulder, hip, and shin pain
Enthesitis due to Ankylosing spondylitis
Blood lab findings in Vit D malabsorption (3)
1) V. Low phosphate
2) Low Ca
3) High PTH
Which vitamin increases INR
Vitamin E
Dx
High Ca, low Phosphate, abdominal pain, constipation, fatigue, excessive urination, urinary stones
Hyperparathyroidism
Hyperparathyroidism predisposes to what arthralgia?
Pseudogout
Which joint does pseudogout usually affect
Knee
Dx
Intermittent abdominal distension, flatulence, greasy stools, iron deficiency anemia
Celiac sprue
Skin condition associated with celiac sprue
Dermatitis herpetiform
Dx study for
BRBPR under 50 with no risk factors for colon cancer
Anoscopy
Most common causes of osteomyelitis in sicke cell (2)
1) Salmonella
2) Staph
Dx
Smudge cells
CLL
Dx
Cause of erectile dysfunction following urethral surgery
Neurogenic
Mechanism of fatty liver
Insulin resistance increases lipolysis leading to fat accumulation in hepatocytes
Dx
High PaCO2 and low PaO2
Alveolar hypoventilation
Dx
COPD with sudden onset of catastrophic worsening of respiratory sx
Pneumothorax (dilated alveolar blebs rupture in the pleural space)
Most common cause of osteomyelitis in children
Staph aureus
Dx
Air fluid levels in the gall bladder in elderly diabetic male
Emphysematous cholecystitis
Dx
Slow onset hazy visual loss
Cataracts
Dx
Focal site of increased radio active iodine uptake with otherwise decreased uptake in the thyroid
Toxic nodule
Dx
HAs worse in morning, n/v early in day, vision changes, somnolence, confusion, hypertension and bradycardia
Increase intracranial pressure
Dx
Bilateral lower extremity weakness following termporal arteritis tx
Steroid induced myopathy
Dx study for
New onset dyspepsia in
1) Over 55
2) Alarm sx of weight loss, dysphagia, vomiting
3) All others
1) Upper endoscopy
2) Upper endoscopy
3) PPI or H Pylori serology
Dx
Insidious onset dry cough in absence of constitutional sx, also with skin lesions and uveitis in african american women
Sarcoid
Dx
Lower leg discomfort at night relieved by massage or movement of them
Restless leg syndrome
Tx for
Restless leg syndrome
Dopamine agonists
Dx study for
Adult with recurrent bacterial infections
Serum Ig levels to consider humoral immunity deficiency
Dx study for
Cancer patient with back pain and neurologic sx particularly bowel or bladder incontinence
MRI of spine
Tx for
Cancer patient with back pain and neurologic sx particularly bowel or bladder incontinence
Dexamethasone to decrease swelling on spine
(while awaiting MRI results)
Tx for
Lactic acidosis from septic shock (3)
1) Fluids
2) Vasopressors if necessary
3) Abx
In patients refractory to HTN tx always treat their lifestyle problems before adding more therapeutics
.
Dx
HA, n/v with enclosed air space occupation
Carbon monoxide poisoning
Dx study for
Elderly pt with new onset delirium
Urinalysis and electrolytes
Dx
Elderly male with dysphagia, regurgitation, foul-smelling breath, aspiration, possibly palpable mass
Zenker's diverticulum
Dx
Chest scan showing primary nodules with a halo sign
Aspergillosis
Dx
Acute pneumonia, cough, fever malaise, hilar lymphadenopathy on CXR, recent travel to Southeastern, mid Atlantic, and central US
Histoplasmosis
Dx
Pneunomia with arthralgias recent travel to SW US
Coccidio
Dx
Liver cysts with multiple cysts inside of the cysts.
What exposure?
Hydatid cysts from Echinococcosis.
Sheep exposure
Dx
Right sided effusion with cirrhosis
Hepatic hydrothorax
Tx for
Hepatic hydrothorax
Tx Thoracentesis and diuretics
If refractory, TIPS
Common drugs that cause hyperkalemia
1) ACE-Is
2) NSAIDs
3) K sparing diuretics (spironolactone and amiloride)
Dx
Hematemesis following multiple episodes of non-bloody vomiting
Mallory Weiss tear (ruptured submucosal arteries of distal esophagus)
Which HepB serology is most useful to determine acute Hep B infection? (2)
ABsAg and anti-HBc antibody
Dx
Corneal vesicles and dendritic ulcers
Herpes simplex keratitis
Mgmt
New onset lupus
Get kidney biopsy then start methylprednisone
Dx
Verrucuous, skin colored or pink papules around anus
Anogenital warts (HPV)
Tx for
Anogenital warts (HPV)
Podophyllin
Tx for
Prolactinoma
Dopamine agonists (bromocriptine or cabergoline)
Mgmt
GERD with dysphagia, weight loss, odynophagia
Upper endoscopy
Prophylaxis for MAC when CD 4 count less than 50
Azithromycin for Mycobacterium avium complex
Most common type of thyroid malignancy
Papillary carcinoma of the thyroid
Dx
Normocytic anemia, hypercalcemia, renal failure, elevated total protein
Multiple myeloma
Dx study for
Multiple myeloma
Serum immunoelectrophoresis
Which compound is increased in androgen producing adrenal tumors?
DHEA
Dx
FEV1/FVC ratio decreased and normal DLCO
Bronchitis
Potential fatal side effect of succinylcholine
Hyperkalemia
Dx
Ca low and Phos low
Vit D deficiency
Dx
Ca low but Phos high.
1) If If PTH v high
2) If PTH high
3) If PTH low
1) If If PTH v high - Pseudohypoparathyroidism
2) If PTH high - Renal failure
3) If PTH low - Hypoparathyroidism
Pronator drift localizes the lesion to where?
Upper motor neuron
What happens to Ca in alkalemia
It binds better to albumin causing effective hypocalcemia despite normal total serum Ca levels
Dx
Post partum woman fails to lactate with pituitary hormonal deficiency
Sheehan's syndrome (ischemic necrosis of pituitary gland following shock from childbirth)
Dx
Tender regional LAD, following cat laceration
Azithromycin for cat scratch disease (bartonella)
Dx
Hypercalcemia, constipation, abdominal pain, weight loss, polyuria, polydipsia
Vit D toxicity
Dx
Pruritic, papules and plaques on face, scalp, chest, and extensor surface of baby sparing diaper area
Atopic dermatitis
Dx
Very high Ca, low PTH, high Phosphate
Hypercalcemia of malignancy
Dx study for
Curtain drop loss of vision
Dx is amaurosis fugax and is usually caused by carotid embolization.
Get carotid artery doppler.
Dx
Ring shaped scaly patch with central clearing and distinct border
Tx?
Dx - Tinea corporis
Tx - Antifungal cream (e.g. terbinafine)
Tx for
Myasthenia crisis
Endotracheal intubation and withdrawal of anti-cholinesterases
Dx
Pneumonia with targetoid lesions on extremities
Lesions are erythema multiform and the patient has mycoplasma pneumonia
Dx
Partially acid fast, filamentous, branching rods on sputum exam
Nocardia
Mgmt for
Severe symptomatic hyponatremia.
And what to watch out for...
1) Hypertonic saline
2) Central pontine myelinosis from too rapid increase in serum osmolality
Dx
What is low in macrocytic anemia when there is peripheral neuropathy?
Cobalmin (Vit B12)
id est not Folate which can correct the anemia but not the neuropathy
Dx
Progressive dyspnea and hypoxia in AIDS patient
Pneumocystis jiroveci
Dx
Vertigo, tinnitus, vomiting, nystagmus
Meniere's disease
Tx for
Meniere's disease
Salt restriction and caffeine, nicotine, and alcohol avoidance
Dx
Loud S1 and mid diastolic rumble
Mitral stenosis
Dx
Clotting history with lupus signs
Antiphospholipid antibody sx (lupus anticoagulant positive which is actually a hypercoagulable state)
Dx study for
Lupus anticoagulant
Russel viper venom test
Which way does PTT move in lupus anticoagulant
PTT increases (paradoxically bc hypercoagulable)
Drug whose side effect profile is
Nephrotoxicity, hyperkalemia, hypertension, gum hypertrophy, hirsutism
Cyclosporine
Drug whose side effect profile is
Nephrotoxicity, hyperkalemia, hypertension,
Tacrolimus
Drug whose side effect profile is diarrhea, leukopenia, hepatotoxicity
Azathioprine
Drug whose side effect profile is bone marrow suppression
Mycophenolate
Tx for
Aortic dissection
Antihypertensives
Mgmt for
Targetoid lesions and malaise, HA, muscle pain, and joint pain
Doxycycline for Lyme (not testing necessary)
Dx
Weight loss, gynecomastia, testicular atrophy, telangiectasias
Chronic liver disease
(hyperestrogen state due to reduced clearance by ****** liver)
Dx
Hx of sudden cardiac death with syncopal episodes and hearing impairment
Long QT
Tx for
Long QT
Beta blockers
Dx
Hypercalcemia and stomach ulcer
Hyperparathyroidism and zollinger-ellison sx suggestive of MEN1
Diagnostic criteria for ARDS
1) Acute respiratory distress in setting of predisposing condition sepsis, pneumonia etc
2) Bilateral infiltrates
3) Normal PCWP
Dx
Normal FEV1/FVC with decreased DLCO
Interstitial lung disease
Clopidogreal indications post STEMI
1) Post UA/NSTEMI for 12 months
2) Post PCI 30 days for bare metal and 12 months for DES
Dx
Contralateral half body pain and temperature loss with cranial nerve defect
Lateral medulla
Dx
Contralateral half body paralysis and proprioception and vibratory loss
Medial medulla
Dx study for
Cough, mucopurulent sputum, hemoptysis that responds to abx
High resolution CT scan for Bronchiectasis
Terrible T's of anterior mediastinal mass (4)
1) Thymoma
2) Teratoma
3) Thyroid cancer
4) Terrible Lymphoma
Dx
Anterior mediastinal mass with elevated alpha feto protein and elevated beta human chorionic gonadotropin
Nonseminomatous germ cell tumor
Dx
Anterior mediastinal mass with elevated beta human chorionic gonadotropin
Seminoma
Dx
Prolonged PT before a prolonged PTT
Vit K deficiency
Dx
Grid test looks like curved lines
Macular degeneration
Dx
Parkinson like rigidity, psychosis, hallucinations, confusions, REM disorder, parkinson sx worse with neuroleptic (anti-psychotics)
Lewy body dementia
Dx
Early diastolic murmur
Aortic regurg
DEXA screening recs
1) Women over 65
2) Women 60-64 if risk of fracture
Yellow fever vaccine is for what countries
Sub saharan africa and S America
Vaccines in HIV
1) Tdap every 10 years
2) Pneumovax (revaccinate in 5 years)
3) Flu annually
4) Hep A and B
5) Meningococcus if asplenic or in college/military
6) HPV (only in high risk individuals)
7) H Flu (only if not given in infancy)
8) MMR and varicella if CD4 over 200
Recs for treated cervical neoplasia
1) Pap smear +/- colposcopy +/- curretage every 6 months until 3 negative results in a row
2) Then resume normal screening for age
AAA rec
ULTRASOUND OF ABDOMEN in all men 65-75 who ever smoked
Pressure ulcer preventino
Repositioning every 2 hours
Mammography frequency
Every 2 years from 50-75 years old
Pneumovax recommendations
1) Everyone over 65
2) Adults under 65 with cardiovascular, pulmonary, hepatic, renal, diabetes, or immunosuppressin
2a) Under 65 need a booster over 65
When colonoscopy starts for 1st degree relative
10 years before their onset
Give hep B vaccine and Ig if exposed with no known immunization history
.
Vaccines for hepatic disease
1) Tdap
2) Flu
3) Pneumovax
4) Hep A and B
Bladder cancer screening in at risk population
Not recommended ever
Dx
Onion skin appearance with moth eaten mottled appearance on bone xray
Ewing's sarcoma
Which metal causes type IV hypersensitivity
Nickel
Auto-Antibodies in scleroderma (2)
1) Anti-Topoisomerase
2) ANA
Mgmt for
Familial colonic polyposis
Procto-colectomy
Dx
Hematuria, deafness, and fhx of renal failure
Alport's syndrome
Pain mgmt in past drug abuser
Opioids (do not deny despite history)
Most common complication of PUD
Hemorrhage
Dx
Dysphagia, CP, food regurgitation, dilated esophagus, bird's beak deformity
Achalasia
Dx
Normal Ca, normal alk phos, low phosphate, and normal vit D with rickets
X-linked hypophosphatemic rickets
(phosphate wasting)
Aphasia localized an infarct to where?
Cortex usually on the Left side (dominant side given R handed)
Dx
Back pain, anemia, renal dysfunction, elevatd ESR
Multiple myeloma
Dx
High alk phos, normal liver tests, hearing loss
Paget's disease
Dx
Intense, focal back pain without neurological symptoms not relieved by rest
Vertebral compression
Dx
Apophyseal joint arthritis
Ankylosing sponylitis
Dx
Intervertebral disc degereneration
OA of the spine
Dx
Falling into chairs, can't raise arms above head, light tremors
Hyperthyroid
Most common type of kidney stone
Calcium oxalate
Dx
Hip pain in setting of corticosteroids
Mgmt?
Avascular necrosis of femoral head
Mgmt - needs MRI
Dx
Circumferential narrowing of distal esophagus with dysphagia
Peptic stricture
Dietary recs for kidney stones (4)
1) decreased protein and oxalate
2) Decreased Na
3) Increased fluid
4) Increase Ca
Dx
PAinful, rubbery nodule on eyelid
Mgmt?
Chalazion
Mgmt - Biopsy
Dx
Mucoid, Gram negative rod
Klebsiella
Dx
Weakness, weight loss, skin color changes
Hemachromatosis
How to diagnose follicular cancer of thyroid from just adenoma
Invasion of capsule
Dx
Mucopurulent urethral discharge, no bacteria on culture
Chlamydia
(think gonorrhea if purulent discharge)
Dx
Hypersegmented neutrophil
Megaloblastic anemia
Increased metabolite differences in Vit B12 and Folate deficinecy
Vit B 12 deficiency: Increased homocysteine AND methlymalonic acid
Folate deficiency: Just Homocysteine elevated
Dx
Motor hemiparesis of face, arm, and leg without other neurologic deficits
Internal capsule
Dx
Hemiplegia, aphasia, hemineglect
Middle cerebral artery
Dx
Contralateral weakness of lower extremities mostly, emotional disturbance
Anterior cerebral artery
Dx
Contralateral hemiplegia with Ispilateral cranial nerve involvement
Vertebrobasilar system (brain stem)
Most likely cancer in asbestosis
Bronchogenic carcinoma
(Not mesothelioma!)
Dx
Ascending paralysis, areflexia, 3-4 weeks after URI or gastroneteritis, CSF shows albumino-cytologic dissociation
Guillan barre
Tx
Guillain Barre
IV Immunoglobulins and plasmapharesis
Dx
Pruritis, tense bullae, uriticarial plaques, with IgG and C3 along basement membrane zone
Bullous pemphigoid
Dx
Follicular conjunctivitis with neovascularization of conjunctiva
Trachoma (chlamydia thrachomatis infection)
Side effect of Anti thyroid meds in grave's disease
Agranulocytosis and allergy
What causes orthostatic hypotension in elderly?
Decreased sensitivity of baroreceptors
Mgmt
AKI due to possible urinary retention
Straight cath (not US for residual volume)
Mgmt
Esophagitis in HIV
Fluconazole empiric tx for candidiasis
If refractory then upper endoscopy for CMV
Mgmt
Solid testicular mass
Radical removal of testis and cord
Prophylaxis for splenectomy
1) Pneumovax, h flu, meningococcus vaccines before surgery
2) Daily oral PCN for 3-5 years after
Dx
Painless hematuria
Bladder mass
People with hemachromatosis are suscpetible to what organism
Listeria
Dx
Progressive proximal weakness with elevated serum creatinine kinase
Myositis and dermatomyositis
Tx for
Myositis
Steroids
Tx for
Gastroparesis
Metoclopramide (prokinetic)
Mgmt
Rapidly developing (over 3 months) male characteristics in woman
Hormone producing tumor
Serum testosterone --> ovarian source
Serum Testosterone and DHEAS --> Adrenal source
Dx
Fever, rash, occipital or posterior cervical LAD, and arthritis
Rubella
Findings in OA
1) Crepitus
2) Bony enlargment
3) Bony tenderness
4) Stiffness without warmth
5) Over 50 yo
Need 3 for a diagnosis
Strongest risk factor for stroke
HTN
then smoking and DM
Traveler's diarrhea
E coli
Dx
Back pain on trauma with ankylosing spondylitis
Vertebral fracture
Tx
Parkinson's
Trihexyphenidyl
How to diagnose parkinson's
Physical exam:
Tremor
Rigidity
Bradykinesia
Dx
HCG and AFP elevated
Nonseminomatous tumor
Acute Migraine tx
Prochlorperazine, chlorpromazine, or metoclopramide
Auto antibody in Primary biliary sclerosis
Anti-mitochondrial Ab
Dx
Autoimmune destruction of intrahepatic bile ducts with cholestasis
Primary biliary sclerosis
Lite's criteria for Exudate
1) Total protein ratio more than 0.5
2) LDH ratio more than 0.6
3) LDH greater than 2/3 of upper limit of normal
Dx
Decreased breath sounds on left after intubation
Accidental intubation of tight main stem bronchus
Renal complication of Hepatitis
Membranoproliferative glomerulonephritis
Causes of pulsus paradoxus (3)
1) Cardiac tamponade
2) Tension pneumothorax
3) Severe asthma
Dx
Vertigo, vomiting, and occipital headache
Cerebellar stroke
Mgmt
Hot potato voice and deviated uvula
Aspiration of abscess
Dx
Large basophilic cells (atypical lymphocytes) with negative monospot
CMV
Dx
Down and out eye with ptosis in diabetic
Ischemic CNIII palsy
Mgmt
Pyelonephritis
BCx Then empiric Abx then if refractory US
Dx
Wedge shaped consolidation on CT scan of lungs
Pulmonary embolism
Respiratory monitoring in Guillain barre
Bedside Vital Capacity
Dx
40 yo male with back pain that is worse in morning and improves during the day
Ankylosing spondylitis
Tx for
Acute cholangitis
Supportive care and Abx
Then
ERCP for biliary drainage and or to remove stone
Dx
Chronic hematomas and joint swelling
Hemophilia
Dehydration: Crystalloids or colloids
Crystalloids
Tx for
Cellulitis with systemic signs
IV Nafcillin
Tx for
Multiple sclerosis
Interferon-beta
Dx
Seizure without LOC or amnesia
Simple partial seizure
Dx
Seizure with LOC, aura, and autamatisms
Complex partial seizure
Dx
Seziure with LOC, tonic clonic activity
Partial seizure with secondary generalization
Mgmt for
Cat bite
Amox clav for pasteurella
Dx
Polyuria in sickle cell trait or disease
Hyposthenuria
3 Mechanical complications post MI
1) MR due to papillary muscle rupture
2) LV free wall rupture
3) Interventricular septal rupture
Dx
Hypothyroidism, HAs, bitemporal blindness
Craniopharyngioma
Dx
ST elevation in II, III, and AVF
Right Coronary Artery occlusion
There are no pathologic changes in IBD!!
!
PPD cutoffs
1) Healthy people: 15 mm
2) 10mm for immigrants, drug users, high risk employees, diabetics
3) 5 mm for HIV, recent exposure to TB, TB on CXR, immunosuppressed PTs
Tx for
Latent TB
Isoniazid for 6 months
Tx for
Active TB
Iszoniazid, INH, rifampin, pyrazinamide for 8 weeks then 4 more months of isoniazid and rifampin
Essential tremor
Absent at rest but present with intentional movement
Tx for
Essential tremor
Beta blockers
Urinary side effects of antihistamines
Anticholinergic effect causes detrussor inactivity
Tx for
Gastric MALT without metastases
Triple H pylori regimen
(omeprazole, clarithromycin, and amoxicillin)
Dx
Dyspnea, fatigue, and peripheral edema following viral infection
Dilated cardiomyopathy due to viral myocarditis
Mgmt
For 1st degree heart block
No tx
Dx
Medial knee pain without positive valgus stress test
Anserine bursitis
Mgmt
Recurrent attcks of focal neurological sx at non predicatable intervals
MRI for MS
Dx
Initial presentation of impaired gait, dementia, and urinary incontinence
Normal pressure hydrocephalus
(Alzheimer's will have more memory and visuospatial impairments)
Dx
Nephrotic syndrome in children with Hep B
Membranous glomerulonephritis
Electrolyte impairments in alcoholism
Hypokalemia with exacerbating hypomagnesemia
also hyphophosphatemia
Dx
Pain and stiffness in the neck, shoulders, and pelvic girdle with morning stiffness and elevated ESR
Polymyalgia rheumatica
Tx for
Polymyaglia rheumatica without giant cell arteritis
Low dose prednisone
What drug to avoid in preexisting lung disease
Amiodarone (causes lung toxicity)
Dx study for
Suspected vasovagal syncope
Tilt table testing
Dx
Thin walled cavities on CXR in pneumonia
Staph aureus
Dx study for
Aortic dissection
Trans Esophageal echo (Not TTE)
or CT with contrast
If anemia despite EPO tx in CKD what's the Tx?
Iron supplements
Tx for
Hepatic fulminant failure (defined as hepatic encephalopathy within 8 weeks of onset of acute liver failure)
Liver transplant
Tx for
Hep C with detectable viral load and evidence of damage (LFTs)
Combined interferon and Ribvarin
Dx
Vague, headache, n/v and closed air space
Carbon monoxide poisoning
Dx
High bp, hypokalemia, metabolic alkalosis, mild hypernatremia, and very low plasma renin activity
Primary Hyperaldosteronism
Indications for Aortic valve replacement
1) Symptomatic AS
2) Pts with AS that need CABG
3) AS patients with LV systolic function or valve area less than 0.6
Dx
Large amount of blood in urine on dipstick by few RBCs on microscopy
Rhabdomyloysis
Dx
Chronic hepatitis, grey green rings in eyes
Wilson's disease aka
Hepatolenticular disease
Dx
Pain radiating to back, Leukocytosis, markedly elevated serum amylase and lipase
Acute pancreatitis
Tx for
Acute pancreatitis
Conservative tx of analgesics, fluids, and NPO
Mgmt
Aseptic meningitis of suspected HSV
Start acyclovir and get cultures later
Mgmt
Acute GI bleed with ABC jeopardy
1) Fluids
2) Protect airway with intubation
3) Upper GI endoscopy to find/stop bleeding
Dx
Fever, lethargy in settin of chirrhosis and ascites
Spontaneous bacterial peritonitis
(usually superimposed on liver failure from cirrhosis)
Mgmt
Fever, lethargy in settin of chirrhosis and ascites
Paracentesis
(positive fluid culture and PMNs more than 250 = Spontaneous bacterial peritonitis)
Dx
Arteriosclerotic lesions of afferent and efferent renal arterioles
HTN
Dx
Increased intracellular matrix, basement membrane thickening, and fibrosis
Diabetic microangiopathy (nephropathy)
Dx
Leukemia with nonspecific esterase positive
Acute monocytic leukemia
Dx
Hypercalcemia in a patient bedridden with truama
Tx?
Immobilization and high bone turnover in healing lead to osteoclast activity
Tx - bisphosphonates
Dx
Curtain fall vision loss, flashes of light, and floaters
Retinal detachment
Dx
Shin rash with bilateral lympadenopathy of lungs
Inflammatory granulomas (sarcoid)
Tx for
Strep viridans bacterial endocarditis
Ceftriaxone or IV penicillin
Side effect of Herceptin (trastuzumab)
Cardiotoxicity
Dx
Renal disease in diabetes
Microangiopathy
Dx
Blood and thunder fundoscopic exam: optic disc swelling, retinal hemorrhage, dilated veins, cotton wool spots
Retinal vein occlusion
Dx
Curtain fall vision loss, pallor of optic disc, cherry red fovea, boxcar segmentation of retinal veins
Central artery occlusion (amareurosis fugax)
Dx
Small cell lung cancer, with muscle weakness
Eaton lambert syndrome (autoantibodies to voltage gated Ca channels)
Dx
IV drug user with mutliple nodules in lungs
Staph aureus vegetation embolizations
Mgmt
Bleeding in liver failure
Fresh frozen plasma
Mgmt
Suspected melanoma
Excisonal biopsy
(if deeper than 1 mm on biopsy need sentinel lymph node study)
Dx
Painless hematuria in young black male
Sicke cell trait
Microcytic anemia with low ferritin
Iron deficiency anemia
Most common cause of low iron deficiency
GI Bleed
Low TIBC in the setting of normal ferritin
Anemia of chronic disease
Tx Iron deficiency anemia
Ferrous sulfate
Acute tenosynovitis
Gonorrhea (gonnococcal arthritis)
Poly joint swelling with flexio
Tenosynovitis
Sheeps, dogs Infection
Echinococcosis
Biliary obstruction (infection)
Ascariasis
Severe granulomatous rxn, hepatosplenomegaly, portal htn
Schistosomiasis
Popcorn calcifications in round solitary nodule
Hamartoma
Temporal headache, scalp tenderness, sisx of giant cel arteritis
Temporal arteritis
Hives with jaundice
Hep B
Asymptomatic low grade hi PTH and hi Ca
No Tx
Iatrogenic Hemolysis in G6PD deficiency
Sulfa drugs (e.g. trimethoprim sulfa)
Most common cause of UTI
E. coli
Dermatitis, dementia, diarrhea (vitamin deficiency)
Pellagra aka niacin deficiency
CV dz (high output failure), neurologic (wernicke-korsakoff sx) Vitamin deficiency
Beriberi aka Thiamine (B1) deficiency
Macrocytic anemia. Vitamin deficiency
B12 deficiency. Etio pernicious anemia, gastrectomy, ileal abnormalities
Osteomalacia in adults, rickets in children. Vitamin Deficiency
Vitamin D deficiency
Ecchymotic rashes around hair follicles, bledding gums
Vitamin C deficiency
Microcytic anemia with low ferritin
Iron deficiency anemia
Most common cause of low iron deficiency
GI Bleed
Low TIBC in the setting of normal ferritin
Anemia of chronic disease
Tx Iron deficiency anemia
Ferrous sulfate
Acute tenosynovitis
Gonorrhea (gonnococcal arthritis)
Poly joint swelling with flexio
Tenosynovitis
Sheeps, dogs Infection
Echinococcosis
Biliary obstruction (infection)
Ascariasis
Severe granulomatous rxn, hepatosplenomegaly, portal htn
Schistosomiasis
Popcorn calcifications in round solitary nodule
Hamartoma
Temporal headache, scalp tenderness, sisx of giant cel arteritis
Temporal arteritis
Hives with jaundice
Hep B
Asymptomatic low grade hi PTH and hi Ca
No Tx
Iatrogenic Hemolysis in G6PD deficiency
Sulfa drugs (e.g. trimethoprim sulfa)
Most common cause of UTI
E. coli
Dermatitis, dementia, diarrhea (vitamin deficiency)
Pellagra aka niacin deficiency
CV dz (high output failure), neurologic (wernicke-korsakoff sx) Vitamin deficiency
Beriberi aka Thiamine (B1) deficiency
Macrocytic anemia. Vitamin deficiency
B12 deficiency. Etio pernicious anemia, gastrectomy, ileal abnormalities
Osteomalacia in adults, rickets in children. Vitamin Deficiency
Vitamin D deficiency
Ecchymotic rashes around hair follicles, bledding gums
Vitamin C deficiency
Drinking vitamin deficiencies
Vit C and B1 (thiamine)
Elevated amylase, elevated lipase, pain radiating to back, “sentinel loo” (air in small bowel LUQ)
Acute Pancreatitis
Fever, tonsilar exudate, cervical LAD, no cough
Strep Infection (usually pyogenes)
Most common causes of exudative (bacterial) URI
Strep pyogenes
50% of AIDS patients have this electolyte abnormality
Hyponatremia
Acute Tx of hemorrhage
1st Saline, 2nd place large bore catheters while blood matching
Diarrhea in AIDs, Eti and Dx
Cryptosporidium or Isospora, AFB stain of stool
Gram positive diplococci in PNA
Strep Pneumo (pnemococcus)
Reduced breath sounds, decreased tactile fremitus
Effusion
Reduced breath sounds, increased tactile fremitus
Consolidation
Tx for migraine
Ergotamine or -Triptans
Prophlaxis for migraines
CCBs
Tx Tension headache (normal headache)
NSAIDs
Cause of kidney stone with pyloneprhritis
Proteus mirabilis (makes urine basic leading to stone), Tx is acidic diet, urease inhibitor, and abx
Most common GI sx of Scleroderma
Esophageal dysfunction (densely fibrotic esphagus)
Lung kidney things
Goodpastures, Wegners, or Churg-strauss
Lung-kidney dz, with C-ANCA or P-ANCA
Wegners C-ANCA, and Churg-Struass = P-ANCA
Lung-kidney dz, with hemoptysis, and linear desposition of IgG in glomerulus
Good pastures
Most common precipitating factor in status epilepticus
Drug Non-compliance
Hypoxemia, hypoglycemia hypotenstion, hyperthermia
Status epilepticus
Sleep apnea with CO2 retention
Pickwickian (obesity hypoventilation syndrome)
Morbid obesity, HIV infection, or heroin abuse with nephrotic syndrome
Focal segmental glomerulosclerosis
Diabetic nephropathy
Kimmelstiel wilson disease
Childhood nephrotic sx
Minimal change diease
Crescent shaped cells accumulate in bowman’s capsule
Crescentic glomerulonephritis
Frank proteinuria
Nephrotic Syndrome
RBCs and protein in urine
Nephritic Syndrome
When to use cryoprecipitate
DIC, von Willebrand,"", and Hemophilia A
Most common cause of pericarditis
Renal failure (when BUN over 100), treat with HD
Hep A IgM and IgG tells you what
IgM acute infection, IgG chronic infxn
Mitral obstruction by mass in atria
Myxoma
Oral ulcers, genital ulcers, arthritis
Bechet’s Sx
Medullary carcinoma thryoid RF
MEN
Papillary carcinoma thryoid RF
Radiation
Prolonged QT Tx
Alkalemic process (like hyperventilation) or bicarb
Cheesy white exudate on oropharynx in AIDS
Thrush from Candida albicans
Most common cause of HIV retinitis
CMV
Human bite infection
Mixed aerobic and anaerobic bacteria
Dog bite infection
Pasteurella multocida (penicilin sensitive)
Most associated with polymyalgia rheumatica
Temporal arteritis
Giving nitroprussides causes hypoxia why?
V/Q mismatch from non-specific pulm vasculature dilation, preventing vasoconstriction of poorly perfused areas
Rapidly progressive respiratory distress
ARDS
Neurologic findings separated by time and location.
Multiple Sclerosis
Sensory hearing loss, facial nerve palsy, cerebellar dysfunction, headache
Acoustic neuroma
Initial Tx for Endocarditis
Get BCx first, then broad spectrum Abx (to not screw up BCx)
Tx severe aplastic anemia
Bone marrow transplant
Hives with pigmented spots, that wheal with blunt object stroking.
Systemic mastocytosis (too many mast cells)
Tx for Supraventricular arrhythmia
Verapamil (or Class III)
Most common cause of ring enhancing lesions in AIDS in brain
Toxoplamosis and Lymphoma (if abx resistant)
Acute angled, branching septated fungus
Aspergillus
Pseudohyphal mycelia with budding yeast cells
Candida
Owl Eyes
Hodgkins lymphoma
Owl eyes + intranuclear and cytoplasmic inclusion bodies
CMV
Fever, headache, anemia, elevated ESR
Temporal Arteritis
Tx Arterial Temporitis
Prednisone
Most common cause of chronic pancreatitis
Alcoholism
Anti mitochondrial Antibodies
.
If no EKG changes with angina, do it with exercisez
.
Every diabetic should be on what besides insulin
ACE-i
Ectopic production ACTH causing cushing
Small cell carcinoma of lung
Side effects of amiodarone
Pulmonary fibrosis (10%), Prolonged QT (1%), skin discoloration common
MS CSF findings
Oligoclonal IgG bands, mildly increased protein
Tx for cerebral edema following stroke
Prednisone
Tx to increase penumbra salvage after stroke
CCBs, Barbiturates, and NMDA antagonists
Cause of abx associated pseudomembranous colitis
C Diff
Complication of C Diff pseudomembranous colitis
Colonic perforation
Linear burrow holes
Scabies, mineral oil Tx
Phenytoin
Folate deficiency
Vanillymandeic acid
Pheochromocytoma
Rapid shift of Na with fluids causing neurologic damage
Central pontine myelinolysis
Stress (hospitilzation) gastritis
Acute erosive gastritis with ulcers
Acute htn crisis Tx
Nitroprusside
Main complication of hepatic adenoma
Rupture into peritoneal cavity
Initial Tx for acute Gout
Indomethacin (NSAID) or colchicine (2ndary), prednisone if refractory, and allopurinol long term
Sinus, lung, skin, and kidney dz
Wegners
Days of rest for musculoskeletal injury
3 days at most
Which Abx cause ATN/AIN
Aminoglycosides (e.g. gentamycin) cause ATN, Penicillins cause AIN
RNP
Mixed connective tissue dz
c-ANCA
Wegner’s
dsDNA
Lupus
p-ANCA
microscopic polyarteritis
Scl-70
Systemic sclerosis
Traumatic brain bleed, lucid interval
Epidural bleed
LOC, worst headache of life, vomiting
Subarachnoid
Putamenal or caudate lobe, basal ganglia, LOC, vomiting
Hypertensive bleed
Flat emotional affect, language disturbances with dementia
Pick dementia
44. Pseudogout= positive bifrengint rhomboids whereas negative befringent needle is gout
.
45. lepromatous leprosy (aggresive) is diff from tb leprosy (milder form, treated w depsone)
.
46. severe sharp chest pain radiating to back and shoulder is classic symptom for aortic dissection
.
47. homeless, alcoholic (aspiration pneumonia) is classically anaerobic (TB is classically in upper lung lobes)
.
48. MRI of brain for not typical cerebral problem s
.
49. pneumonia: decreased tactile fremitus over the right hemithorax
.
50. sarcoid
.
Mononucleosis
Splenomegaly + LAD, Heterophil is another name for monospot test, which is positive. Atypical lymphocytes on on blood smears
CLL
B lymphocytosis, lymphadenopathy, if only those two, no treatment. First line treatment is chlorambucil. If that fails use fludarabine. Bone marro transplant is reserved for very young patient.
DM I
Associated w HLA DR3 and DR4
Alcoholic Hepatitis
AST/ALT is greater than 2
Huntington
Familial, irritiablity, restessness, diff. concentration, and onset between 30-50. Autosomal Dominant
Hypervolemia
Can cause hyponatremia
Narrow Angle Glaucoma
Red Eye, extreme pain, blurred vision with halos most frequent in Asians. Test this with tonometry to test pressure.
Pneumonia in AIDS patients
Bacterial pneumonia is the most common form if AIDS patients. MAI causes a wasting systemic disease not like pneumonia. TB has crhonic or subactue, with cough fever and drenching night sweats. PCP only in severe CD4 count depression.
Membranous Glomerulopathy
Hep B is the most common infection cause, with syphyillis a second. Most common renal complication in AIDS is focal segmental. C3 refers to IgG which is found in membranoproliferative. IgA is in Berger disease, with flu like symptoms.
Acromegaly
Tested after a glucose supression test. People have fluctuating baselines, so you want to try and balance that out by supressing glucose. THEN you do MRI and or CT.
Secondary amenohrea
Most Common Pregnancy. Once rule out pregnancy, then CT.
Renal Cell Carcinoma
Flank Pain, Hemature, and Abdomina mass. Can cause hematurea, weigh loss. and history cigarette smoking.
Charcot Triad
Jaundice, fever, RUQ: cholangitis, Cholecystitis rarely give you fever.
Indirect Billirubinemia
Hemolysis (, spherocytosis etc). Cihhrosis only causes diret.
Diabetes and Hypertension
Give them an ACE is first line
Hypercholesterolemia
most common cause ia defect in the LDL receptor (look up class scheme for memorizing the rest).
Trichinosis
Is the nematode, common from boar, bear, pork, or horse. You get muscle invasion, intestinal stage with diarrhea, and blood eosinophilia, elevated creatine kinase. Chagas is caused by trypanosomiasis.
Metabolic Acidosis
Need to have Ph standards and also responding appropriately with a respiratory alkalosis.
Aluminum hydroxidde
Caused by aluminium containing antacids. Calcium carbonate can cause a hyperphosphatemia.
Alcoholism
Associated with carbohydrate deficient transferrin levels.
NSAID use
misoprostal supposedly helps, questionable
Mycoplama Pneumonia
Erythematous painful papules on the tympanic membranes, and cold agglutinins which precipitate on colloing is pathognomonic for Mycoplasma. Treatment is erytromycin.
Meniere’s Disease
Vertigo, Tinnitus, and feeling of swelling.
CREST syndrome
only have thicknede skin on theri hadn and face, as opposed to more diffuse.
Reflex Esophagitis
Squamous to Columnar metaplasis and goblet cells, is a garrets esophagus. Long fingers is also Barrets.
HOCM
Initial therapy is beta blockers, or CCBs.
Central Pontine Myelonlysis
demylenination from volume shifts
Hypeparathyroidism
Most common casue of hypercalcemia in patients.
Erythema Multiforme
Variety of morphologies, sudden onset, also target lesion.
Erythema Migrans
Lyme
Suspected Biliary obtruction
Start with ultrasound
Ankylosing Spondylitis
Early onset, before 40, and involvemtn of sacroilliac joints.
Why would Bacterial endocarditis blood screen be negative
BC they got antibiotics before doing teh culture
Steatosis
Most common causes are alcohol use, obesity, or DM.
Radial Palsy
Triceps, brachioradialsi, wrists, and finger and thumb extensors
PBC
Assocaited with antimicrobial autoantibodies
PSC
Most associated with Ulcerative Cholitis.
Anti Smooth Muscle
Autoimmune chronic hepatitis
Clinically Following Ascites
Follow their PT, which is a proxy for synthetic capability. Bleeding time is a marker of platelet function.
Hypothermia
helps chances for better outcomes. Sedation is also useful, but only if hypothermia doesnt work. Hyperventilation is only indicated by if there is ICP.
Malignant Hyperthermia
Patient was given succinylcholine, which can cause muscular contracture.
Takayasu Arteritis
Inflammation of aortic arch or branches, frequently pulseless, can cause ischemia to brain
Wegeners
C-Anca
Atopic Dermatitis
Is Eczema
Nummular Eczema
Coin Shaped Lesions, scaly crust
Seborrheic Dermatitis
Scaly oily dandruss rash on the scalp and eyebrows.
Paget Disease
Mostly older, Heavy osteoclastic and osteopblastic, coarsely woven, thrick, heavily cacifed but weak. Frontal bossing, bow legs
Schistosomiasis
Infective larvae are excreted by snails and penetrate through skin or mucous membrane. Recurrent hematuria and predisposes to squamous cell carcionma. Search for OVA.
Pyelonephritis
Start IV ampicillin and gentamycin
Von Willebrand disease
Factor VIII deficiency, will extend PTT. Factor VII extend PT. Factor IX will extend PTT, is hemophila B. Hemophilia A is also a IIX deficiency, prolongs PTT< and is x linked.
Fat Emobolism
Dyspnea, tachypnea, tachycardia, with diffuse bilateral inflitrates consistent with ARDS and a self limiting petechial rash.
DKA
Osmolar diueres: leads to volume depletion, need volume, need insulin, and D5W.
AtlantoAxial joint
Upper motor neuron symptoms, so it must be above the heart.
Digoxin Toxicity
DIG is renally excreted
Scurvy
Vit C deficiency: bleeding from teh gums, capillary fragility, petehia, eccymoses, poor wound healing,
External Otitis- necrotizing/malignant
Most Commonly caused by pseudomonal aeruginosa. Cipro is the treatment of choice.
Anti-centromere antibodies
Specficially to the CREST variant of systemic sclerosis. Calcinosis, Reynauds, Esophageal dysmotility, Sclerdacyly, telangectasia
Rebound Tendernes and rigid abdomen
Describing perforation or its in the peritoneal space.
Pseudogout
rhomboidal positive birefringent crystals , Gout is negative needles
Burkitts Scan
Starry SKy, Africa
Follicular Small Cleaved Cell lymphoma
Waxing and Waning lymphadenopathy,
Ankylosing Spondylitis
Seronegative spondyloarthropathy, make sex, young, sacroillitis, large joing arthritis, aortic regurgitattion, low back pain
Menetrier Disease
Thickened Gastric folds, low acid secretion, protein loss and edema, weight loss
Scrufulla
TB infection in the neck
Positive TB
On isoniazid if seropositive for 6 months and have contacts with people with TB
Acute Gout Therapy
NSAIDS, then colchicine, then steroids
Caroli Disease
Associated wtih biliary cirrhosis, adn can develop hepatic fibrosis. Dilation of intrahepatic bile ducts
Crigler Najjar
Inherited enzymatic abnormality of the liver that causes hyperbilirubinemia
Dubin Johnson
Enzymatic disorder that causes dark grey liver and hyperbilirubinemia
Gilbert Syndrome
Asymptomic hyperbilirubinemia
Rotor Syndrome
hyperbilirubinemia without liver discoloration
Malaria
Should be looked for in blood smears. They have waxing and waning fevers (three day disease), blood smears should be examined every 8 hours during and between febrile attacks Treatment for malaria is chloroquine.
Myelophthisic Anemia
Small schistocytes, fragment, red cells. Happens when your bone marrow cavity is taken over by tumor, fibrosis, or other things.
Hypochromic Macrocytes
Folate defiency, vitamin B12, and thalassemia
Ringed Sideroblasts
Sideroblastic anemia, problem with erythrocyt maturation adn utilization iron
Cholecystitis
Symptomatic, treat with lap coli
Anal Cancer
HPV
Neutrophilic predominant
Baterial, Lymphocytic (less bacterial)
CEA
Colon Cancer. AFP liver, ovary, and testicular Cancer.
Atypical Pneumonia
Mycoplasma pneumoniae, chlamydia, coxiella burnetti. THe interstial patter is what characteristics.
Magnesium Deficiency
Malabsorption, or kwashiorker, . CHronic alcoholism is another cause of magnesium deficiency.
Hemochromatosis
hepatomegaly, arthlargias, skin hyperpigmentation. HFE protein mutation.
Treatment of Prolactinoma
is bromocriptine
Hypertensive Hemorrhage
MOst common in putamen, but if the symptoms are cerebellar, then its cerebellum. Putamenal hemorrhage usually leads to contralaeral hemiparesis, hemianesthesia, and hemianopia
Basal Cell Carcinoma
Most common cause, pearly, rolled edges. Melanoma pigmentation. For squamous stuck on appearance, not ulcerated.
OSA
Poor nightitme sleeping, day time sleepiness
Prostatic Hyperplasia
If IV contrast posioning, its going to be within 24 hours, not a week.
Alcoholic aspiration pneumonia
Klebsiella
Inferior MI
RCA occlusion
Coffee ground emesis, pain killers
gastric ulcers
quick onset food poisoning
Staph aureus, B cereus
most common cause of hemoptysis in adults
chronic bronchitis
Vit K def.
Abx can cause Vit K def, but also TPN
Hyperpigmentation and hypocortisol
Addisons
Constrictive Pericarditis
Increased venous distension on inspiration (kussmaul’s sign)
Radioactive Iodine Scan
only needed if there are symptoms of thyrotoxicosis. If there are no symptoms and there is a nodule for FNA to make sure its benign.
Brain Abscess
Afebrile, and can exhibit progressive neurologic symptoms
Psyllium
A bulking agent that you use before laxatives.
Aplastic Anemia
Fat in bone marrow.
Ramsay Hunt
Cranial Nerve 8 with shingles. Vesicles in the ear. Facial Palsay
Menieres Disease
One sided Tinnitus, Deaffness, and vertigo. Fullness
Pityriasis Rosea
Scaly lesion that involves the trunk, sometimes a christmas tree appearance
Pityrisasis Rubra pilaria
involves the hands and soles and does not produce a herald patch
Scabies
Small skin burrows in addition to papules, itching is prominent
Rovsing Sign
Acute pendicitis
Htn
Confirm within two months
Hypoparathyroidism
Feedback inhibition
Hungry Bone syndrom
Will happen days or weeks, with patients with hyperparathyroidism
Syphillis
Use penicillin, if theyre allergic use doxycycline.
alcohol cardiomyopathy
Leads to dilated. S3 is also indicative of dilated.
Antiphospholipid Antibody
Hypercoagulable (or anticardiolipin), can lead to thrombosis
Acute adrenal insufficiancy
It happens when you remove steroids, treate w IV hydrocortisone, adn then confirm diagnosis by measuring. confirm by measuring cortisol levels
Mesothelioma
Smoking is not a risk factor, Asbestos.
Tear Drop
Idiopathic myelofibrosis. The bone marrow is crying, also wil have bone marrow fibrosis `
Increased RBC mass
PVERA
Acetaminophen Entoxication
7 grams is necessary, unless you already have liver dysfunction
Medullary Carcinoma
Men 2a associated with medullary cancer, treat!
paracetomol
aspirin.
Antirheumatics
For disease progression, use Nsaids and steroids for symptom control
Neomycin
Lactulose is given classically to wash out the bateria, and neomycin, a poorly absorbed aminoglycoside, that allows it to destory the ammonia producing bacteria
Dig Toxicity
yellow green cast to the vision, also known as xanthopsia/verdopsia, bradycardia
Conn Disease
Primary hyperaldosteronism
Hashimoto thyroiditis
Goiter, antibodies against thyroglobulin, and with lymphocytes.
B thall
Do electrophoresis. RDW is less than 15%. In iron def. there is more deficiency, and RDW is greater than 15%
Kidneys plus HTN
ace inhibitor
Sickle Cell
Hydration and Narcotics
Howell Jolly Body
rbcs with their nucleus
Nephrotic syndrome
you lose anticoagulant proteins
Hodkins (stage IV)
Treat with chemo
G6PD
fava bean, done, heinz bodies, makes cells vuln. to cell damage
Pancreatic CAncer
Look at amylase, lipase
EPO in the setting of CKD, dialysis
can cause hypertension in 20% of cases
Effect on dexamethasone test and what it tells you.
Decrease ACTH secretion by pituitary only, so if ACTH or cortisol remains high, non pituitary source.
Startle myoclonus (jerks causes by loud noises)
Creutzfeld Jakob
Why is lung cancer screening not effective?
Even when primary tumors are detected, bc high rates of metastasis are usually already present
First treatment in hypercalemia
Restore volume. Hypercalemic pts are dehydrated, restoring improves GFR and Ca clearance.
Cough, fever, and yellow sputum in healthy person. Dx?
Acute bronchitis
First imaging in Diverticular Disease?
You want to do a barium enema, but you need an x-ray first to make sure there are no perforations first.
Insulin high, C-peptide low, insulin AB
Exogenous source of insulin.
Exposure to plants, chain of lesions. Dx?
Sporotrichosis
Tapping causes facial twitch. Dx?
Hypocalcemia (Chvostek sign)
Hyperpigmented, sharply marginates lesions on healthy person. Dx?
Melasma
Signs of cholestasis + antimitochondrial Ab. Dx?
Primary biliary cirrhosis
% HCV infection that becomes chronic
75% (HBV, 5-10%)
Patchy hypopigmentation of skin. Dx?
Vitiligo
Antihypertensive med that causes hyperkalemia
ACE inhibitors
Painful thyroid gland. DDx?
Subacute thyroiditis
Delayed carotid upstroke
Aortic stenosis
Hyperbilirubinemia with otherwise normal lab values & no other symptoms. Dx?
Gilbert’s syndrome
Slowly developing nodular lesion with central ulceration. Dx?
Basal cell carcinoma
Most important factor affecting long-term success of TIPS or liver transplant
Abstinence from alcohol
Diagnostic test for suspected pituitary adenoma
Serum prolactin (before head MRI)
Fungus in the Southwest US
Coccidioides immitis
Elderly patient with subacute onset of dementia, urinary incontinence, gait disturbance
Normal pressure hydrocephalus
Procollagen I deficiency
Osteogenesis imperfecta
Cryptococcal meningitis tx
Amphotericin B (the oral fluconazole)
Proximal weakness & elevated CPK
Polymyositis
Polymyositis tx
Corticosteroids
Cause of black pigment gallbladder stones
Hemolysis
Cause of brown pigment gallbladder stones
Infected bile
Elevated urinary 5-hydroxyindoleacetic acid (5-HIAA)
Carcinoid syndrome (5-HIAA = serotonin metabolite)
Elevated urinary vanillylmandelic acid (VMA)
Pheo (VMA = catecholamine metabolite)
MALT lymphoma tx
Antibiotics (to eradicate H pylori)
Positive direct Coombs test
Autoimmune hemolytic anemia (detects C’ or Ab on RBC)
Cold agglutinins
#ERROR!
Loss of speech discrimination + tinnitus
Schwannoma of CN VIII (aka acoustic neurinoma)
Ascending paralysis
Guillain-Barre
2,5, and 10 LRs correlate to what additional post test probabilities
15%, 30% and 45%
Triple AAA screening
Male between 65 and 75 and ever smoked.
When to get pneumovax?
Everyone over 65. If active smoker, COPD, or asthma they should get it earlier.
Who can get live attenuated flu vaccine intranasally?
Less than 50, immuncompetent with no immunosuppressed contacts.
Who definitely needs Flu vaccine?
Everyone. And can be dead or attenuated unless immunosuprressed.
Who should get zoster vaccine?
All immunocompetent 60 and older regardless of prior hx.
Who gets Tdap?
All between 19-64 who haven’t gotten booster.
When to give Tdap immunoglobulin.
Patients with wound who do not have reliable Tdap hx.
Who doesn’t need Tdap?
If they had Tdap within 5 years, or have a clear wound and a Tdap within 10 years.
Who should get HVP vaccine?
All girls 9-26
Acceptable Colorectal screening options (4)
1. Colonoscopy every 10 years starting at 50
Syncope in heart failure with ischemia. Dx?
Vtach
Common cause of syncope, must check this test especialy in diabetics.
Orthostatics
Syncope with prodrome of nausea, light-headedness, and diaphoresis. Dx?
Vasovagal (situational/neurocardiogenic) syncope
Syncope with lack of prodrome. Dx?
Arrhythmia
Best diagnostic study for infrequent but recurrent syncope.
Loop recorder
Tx if first anti-depressant fails.
Another antidepressant.
Tx for suicidal ideation
Urgent inpatient admission
When bereavement becomes inappropriate and should be considered for SSRI
At least 2 consecutive weeks of depression 8 weeks after death of loved one
Hx of self harm, dysfuntional relationships, intense anger. Dx?
Borderline personality disorder
First line Tx for acute alcohol withdrawal.
Lorazepam (ativan)
Tx for acute cocaine intoxication
Benzos (lorazepam)
Why can’t you give B blockers to coacine ODs?
Selective beta blockers will block the sympathetic effects on heart, while the cocaine alpha vasoconstricts the vasculature. Can give non-selective beta blockers.
When to give haloperidol?
When psychosis present
Tx for drug induced seizure
Benzo (not anti-epileptic)
Tx to prevent relapse in alcoholism?
Naltrexone (also can be used for opioid addiction)
Tx for acute opioid overdose
Naloxone (narcan)
Tx for long term opiate addiction
Suboxone (buprenorphine)
Screening for alcoholism
CAGE
Initial tx for spinal stenosis. Refractory tx especially if neurologic impairment.
NSAIDs. Surgery for refractory.
Diagnostic study for back pain, with possible infection.
MRI bc can detect acute osteomyelitis changes that CT and x-ray can’t
Tx for acute non-specific low back pain.
NSAIDs or acetaminophen
Dx back pain, muscle weakness, bowel or bladder incontinence.
Spinal cord compression
Dx study Cancer patients with possible spinal cord compression
MRI of spine
Tx for cough variant asthma
Albuterol inhaler trial
Tx for chronic cough without CXR findings
Anti-histamine and decongestant
Diagnostic study for hemoptysis in healthy and cancer suspicion
Healthy - CXR
Tx for acute bronchitis
Symptom management (if over 3 weeks, get CXR)
Lung function improvement in COPD following smoking cessation.
Improved lung function (2%) and decreased rate of decline by half
Cardiovascular risk relation to smoking status
Pack years are irrelevant, but stopping smoking rapidly improves outcome within 5 years of cessation.
Tx for smoking cessation
First line - Verenicline
Indications for bariatric surgery
BMI over 35 with co-morbidities, or over 40 without comorbidities AND unsuccessful weight loss with diet and drugs.
Tx for pharmacologic treatment of obesity
Orlistat
Dx Nausea and vomiting following bariatric surgery
Stomal stenosis
Dx study Stomal Stenosis suspicion after bariatric surgery
Upper endoscopy
Dx for weight loss, lack of focal sx, lack of f/c/ns, and normal labs and imaging.
Re-evaluate in 6 months
Dx systemic weight loss, skeletal muscle dysfunction, osteoporosis, and depression with trouble breathing.
COPD
Tx for excessive menstrual bleeding
If considerable - medroxyprogesterone
If less - Oral contraceptives
.
Dx Oligomenorrhea, hirsutism, acne, alopecia
PCOS
Tx for menopausal sx
Estrogen replacement therapy
Dx for secondary ammenorrhea
Progestin withdrawal study
Initial Dx study for amenorrhea
FSH, TSH, and prolactin levels
Dx study for Abnormal uterine bleeding in over 35
Endometrial biopsy to diagnose most likely cause (endometriosis) and rule out cancer or hyperplasia
Dx well demarcated, rapidly spreading area of warmth, swelling, tenderness, and erythema.
Cellulitis
Dx erythematous, dry or greasy scales and crusts.
Seborrheic dermatitis (dandruff)
Dx Pink/red papules and thin plaques with scaling active borders and central clearing.
Tinea cruris
Acute, severe, reaction after drug use with erythematous macules and plaques involving mucus membranes but less than 10% of body.
Steven Johnson syndrome
Red Man Sx rxn to what?
Vancomycin
Dx targetoid lesions, with skin and mucusoal involvement
Erythema multiforme
Dx Spreading ring of erythema
Erythema migrans (Lyme)
Dx Subtle, fine, pink Blanching macules and papules that spreads centripetally
Rocky mountain spotted fever
Tx for shingles
Oral valcyclovir or famcyclovir
Dx erythema, telangiectasias, pustules, and sebaceous hyperplasia, that does not spare nasolabial folds.
Rosacea
Dx common, benign neoplasms that are black or brown, well demarcated, stuck on with waxy surface.
Seborrheic keratosis
Tx for non-inflammatory acne, mild inflammatory, or gross inflammatory
1) Benzoyl peroxide, salicylic acid, or retinoids
Dx acute, rapid wheal, superficial, itchy, discrete swelling, lasting less than 24 hours
Acute urticaria (chronic if more than 24 hours)
Dx study for isolated axillary lymphadenopathy that is immobile
Lymph node biopsy
New onset urinary incontince causes (DIAPERS)
Drugs
Dx study for Elderly hearing impairment
Whispered voice test
Dx study for Gait and balance problems
Get up and Go test
Tx for Urge urinary incontinence
Tolterodine or Oxybutynin (anticholinergics)
Dx Slow urinary stream, urinary hesitancy, and nocturia
BPH
Chlorthalidone is what class?
Hydrochlorothiazide diuretic
Target bp for T2DM?
130/80
Dx systemic htn, radial to femoral artery delay, and rib notching.
Coarctation of aorta
Stages of HTN and initial Tx
Stage 1 - 140/90 (HCTZ)
Lateral epicondylitis (tennis elbow)
lateral elbow pain on wrist extension.
Rheumatoid
PIP is always rheumatoid. Heberdeens nodes are DIP, bouchards are PIP
Trochanteric Bursitis
Localized hip pain, and resisted abduction of the hip worsens the pain
Positive McMurray Test
Meniscal Tear
Anserine Bursitis
Focal tenderness on the upper, inner tibia, about 5 cm distal to the medial articular line of the knee
Rotator Cuff Tendinitis
Think baseball pitcher, subacromial tenderness, pain reaching overhead or lying on shoulder
Adhesive capsulitis
decreased ROM, stiffness not pain or weakness
Torn Rotator Cuff
positive drop arm test (cant smoothly drop arm)
Polymyalgia Rheumatica
15% of people w this have temporal arteritis. 50% of people with temporal arteritis have polymyalgia rheumatica. Pain with neck shoulders and hips. Treat w methotrexate as a steroid sparing agent.
Tx for Community acquired septic arthritis with G+ cocci
Vancomycin (cover for possible MRSA)
Tx for Gonoccocal septic arthritis (G- cocci)
Ceftriaxone
Acute monoarthritis
Is septic until proven otherwise. Need to do arthrocentesis.
Dx Pain in the absence of fever and leukocytes in patient with prosthetic joint
Prosthetic joint infection (sic)
Treatment of GOUT
Indomethacin (is an NSAID), then colchicine and steroids
Changing Gout therapy
Initiating or changing allopurinol levels must be done w prophylactic nsaids, colchicine, or steroids to avoid an acute attack
Pseudogout
Positive birefringent rhomboids
OA
pain that worsens w activity, relieved by rest, key is that thereis no erythema or warmth. First line therapy is PT
De quervain tenosynovitis
pain on palpation of distal aspect of radial styloid. finkelstein test is positive.
Dx Chronic pain at base of thumb with positive grind test
OA of thumb
OA
First line is acetaminophen + PT, if that fails, then use NSAIDS
Dx joint space narrowing, subchondral sclerosis, osteophyte formation
OA
Dx study for suspected RA (best sensitivity)
X-ray, look for erosions of cartilage, joint space narrowing
Start TNF alpha, then what?
Check tuberculin skin test. Why? Reactive TB
Tx for RA (3)
1) Initially NSAIDs and DMARDs (methotrexate) hepatoxicity is possible, use hydroxychloroquine then
HLA-B27
Ankylosing Spondylitis
Dx oligoarticular arthritis involving lower extremities in setting of IBD
Enteropathic arthritis
When there is an explosive onset of psoriasis
Think the Hivvy
Most commonly systemic illness in pts. with anterior uveitis
reactive arthritis, ankylosing spondyltitis, and sarcoidosis
Dx of Ankylosing spondylitis
MRI of sacroilliac joints
Anti DS DNA
SLE
Antiribonucleoprotein antibody
Mixed connective tissue diease
AntiSSA SSB (ro-la)
sjogrens, (also in subactute cutaneous lupus)
Anti topoisomerase (anti scl 70),
scleraderma
Drug Induced lupus treatment
Seen with methotrexate use, stop the drug, treat w prednisone to control pleuritis and synovitis associated
Lupus Nephritis
Treat with high dose corticosteroids, and ACE inhibitors
Comorbidities of polymyositis and dermatomyositis
ILD with progressive fibrosis and secondary PAH.
Dx Diffuse pain on both sides of body, above and below waist, as well as axial skeletal pain.
Fibromylagia
Tx of Raynauds
CCBs (amlodipine)
Polyarteritis Nodosa
Necrotizing inflammation of the medium sized or small arteries. Fever, msk, affects the kidneys, causes htn,
Dx HA, temporal artery tenderness, acute visual loss, dever, milad anemia.
Giant cell arteritis
Tx for Giant cell arteritis
Immediate corticosteroid Tx even before diagnostic testing
Abdominal Fat pad aspiration
AL amyloidosis diagnosis
Dx CP with exertion, Trop negative, EKG negative
Stable angina
Dx CP even at rest or unpredictable/increasing, Trop negative, no ST elevation
Unstable angina
Dx CP even at rest or unpredictable/increasing, Trop positive, no ST elevation
NSTEMI
Dx CP even at rest or unpredictable/increasing, Trop positive, ST elevation
STEMI
Need 2 of 3 of these to Dx acute pericarditis
1) Pleuritic CP (worst when supine)
Tx for STEMI
Percutaneous angioplasty and stent placement (unless PCI more than 3 hrs away, then do thrombolysis within 12 hrs)
Dx CP with predictable relation to exercise relieved with nitroglycerin
Stable Angina pectoris
Dx Acute hypotension, clear lung fields, elevated central venous pressure (Right precordial ST elevations)
Right ventricular MI
Tx for Esophageal noncardiac CP
Empiric proton pump inhibitor
Most common cause of marked bradycaria and manifests as absence of atrial ventricular association
3rd degree heart block
Dx palpitations, sweating, tremulousness, dyspnea, CP, nausea, dizziness, numbnees.
Panic attack
Tx for recurrent panic attacks
SSRI (paroxetine) and CBT
Dx Severe headache, diaphoresis, palpitations
Pheochromocytoma
Dx Progressive prolongation of PR interval
Mobitz type I (2nd degree AV block)
Tx for Stable angina (initial medical)
1) ASA
Dx CP, dyspnea, leg edema, elevated CVP, tachypnea, and tachycardia
PE
Dx study for suspected PE
CT Pulmonary angiography (PE protocol)
What does normal wall motion on ECHO during CP allow you to do?
Exclude coronary ischemia and infarction.
Dx study for atypical CP with normal resting EKG
Exercise stress EKG test
Dx Narrow complex, regular tachycardia, absent p waves, but sawtooth baseline
Aflutter
Dx Either symptomatic sinus bradycaria, OR tachy-brady sx
Sick sinus syndrome
Dx PR interval greater than 200 ms
1st Degree AV Block
1. Tactile fremitus decreased and dullness to percussion over area; rales, crackles or bronchial breath sounds; egophony, bronchophony, and whispered pectoriloquy: Pneumonia PE findings
.
2. Fever, productive cough, elevated WBCs, hypoxemia, new lung infiltrate → Pneumonia
.
3. Lobar consolidation in pneumonia → Strep pneumo
.
4. Interstitial infiltrates in pneumonia → Mycobacterium pneumia or Pneumocystis carinii
.
5. Cavitary pneumonia → anaerobes, gram negative, or tuberculous pneumonia
.
6. Pleural effusion → Strep pneumo
.
Dx
Pruritis after bathing
Polycythemia vera
Leukesterase means what?
Nitries mean what?
Leukesterase = infection of UTI
Nitrites = enterobacter infection
Dx
Spasticity, bulbar symptoms, hyperreflexia, fasciculations
ALS
Tx for
HA, nausea, eye pain, vision loss, redness in eye
Dx is acute glacucoma
Tx is Mannitol, acetozolamide, pilocarpine, +/- Timolol
Dx
Fever, hypotension, generalized erythema, desquamation
Toxic shock syndrome