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22 Cards in this Set
- Front
- Back
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Preclinical |
Scale up + Good Formulation |
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Hydrogen bonds |
S-S bond between two cyastines -> stabilize the molecule |
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Amino acids |
Secondary arrangments in the protein. |
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Primary Structure* |
Amino acids sequence which differs between proteins. |
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Secondary Structure* |
3D structures which are fromed by hydrogen bonds between the amino acids. |
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Alpha Helix |
CO interacts with the NH2 on the upper amino acids. 3.6 per round |
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What breaks alpha structure? |
Prolein Mostly |
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Beta Sheets (secondary structure) |
Meshor- CO-NH2 down up - R's |
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What force in beta sheets? |
Hydrogen bonds + van der waals + ionic |
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Tertiary structure |
Alpha-Alpha-Alpha |
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4 sturcture |
Protein-Protein-Protein (Tat protein) |
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Active site |
Polar amino acids!! |
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Binding site > Active site |
Hydrophobic(binding) --> substrates |
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electron density + |
Heset + -> better |
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NMR |
Soluble proteins |
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Most proteins are |
L, except the wall of bacteria (D) |
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Methionine |
Non polar |
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Pka>Ph |
OH |
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Proline |
Non polar CH2-CH2-CH2(triangle) |
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Charged Amino Acids |
Lysine + Arginine + Histidine (LAH) |
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Aromatic |
Phenylalanine, Tyrptopan, Tyrosine ( PTT) |
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Dielectric higher |
weaker ionic bonds water>fat>vaccum |
