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29 Cards in this Set
- Front
- Back
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approx __ of cancer patient diagnosed with cancer n the US each year will develop recurren tor disseminated neoplastic disease
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2/3rds
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whihc of the following agent sis not derived from teh periwinke plant?
a. Vinca Alkaloids b. Cyclophosphamide c. Vinblastine d. Vincristin |
B is INCORRECT
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one of the major long term side effects of MOPP is
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gonadal damage and consequent sterility
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which chemo agent belongs tot he antimetabolites and pyrimideine analogues
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fluorouracil
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phase___ studies are designed to estabilsh the value of a new tx relative t an existing tx
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phase III
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chemotherapy has offered teh possibility of complete cure for each of the following EXCEPT
a. lung b. choriocarcinoma in women c. disseminated Hodgkin's disease in children and young adults d. ALL in children |
except A lung
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cardiotoxicity has been associated with patients receiving radiation to portion o the heart or cyclophosphamide therapy with :
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D. Idarubicin, daunorubicin, mitoxantrone, and adriamycin
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each of the folloing stateents are correct regarding tumor cells esistance to chemotherapy demonstrated in animal and human tumor cells EXCEPT
a. decreased drug activating enzymes b. decrease DNA repair c. increased levels of inhibited target cells d. increased in drug removal from teh cells |
except B
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busulfan, mitomycin-C, and bleomycin when administered has been associated with
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pulmonary fibrosis or toxicity
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the objective of this clinical trial is to determine the max. tolerated dose defined by max toxicity, to study the clinical pharmacology, and to describe tumor responses noted in the study define Phase____trials
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Phase I
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each of the following are estrogens EXCEPT
a. DES b. Premarin c. DEX d. Estinyl |
C DEX
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each of the following are considered antigen-presenting cells EXCEPT
a. b-cells b Langerhans cells c. dendritic dells d. t-cells |
except D t-cells
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itis uncommon for a patient with at performance status below____to be on chemo, unless a resonse of the particular tumor is hightly liekly and the patietn is motivated
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3
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each of teh following agents prduce biphasic suppression of peripheral granulocytes EXCEPT
a. melphalan b lomustine c BCNU d. bleomycin |
Bleomycin
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the peak incidence of teh onset of a secondary acute leukemia folloing previous chemo is
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3-9yrs
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vincristine, bleomycin, doxorubicin, and cyclophaide are associated with
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alopecia
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prolonged adinistration of methotrexate, 6 mercaptopurine or L asparaginase are associated with
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liver toxicity
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a type of non-viral gene transfers which is considered teh most simple means in deliverering foreign DNA into tissues and can be used for vaccination against infectious agents and cancer immune therapy is
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Naked DNA
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Whichof the following is knwn to trigger a host immune response which begins in the first few hrs by delivered viral protein and is assoc. with a cytokine and mobilization of immune effector cells' preferentially replicates adn kills TP-53 mutated tumor cells
a. oncoviruses b. HSV-1 c. Adenovirus gene vector d. Lentivirus |
C adenovirus gene vectors
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often considere dthe most significan tumor suppressor gene, it has been used as a guardian of genome in DNA repair and induction of apoptosis in G1/S boundary ovarn, small cell lung, cervical, H/N and melanoma cancers appear affect by __
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TP-53
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each of the following are retroviruses EXCEPT
a. spumaviruses b. HSV amplicons c. lentiviruses d. spumaviruses |
B
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ONYX-015 and HSV-1 with a deletion of the gamma gene are examples of this type of viruses that selectively replictes in the lyse tumor cells as opposed to normal cells
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C. replication-cometent oncolytic viruses
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each of the following represent a main class of lyphocytes Except
a. Null or double negative cells b. b-cells c. MHC d. Tcells |
C MHC
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each of the following TAAs have been used in clinical trial to target the folloiwng tumros EXCEPT:
a. PSA-prostate b. CEA-breast, Gi, and lung c. HER2/neu-breast d Ca125-breast |
D is incorrect CA125=OVARY
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administration of gents that iic or enhance a patients immune response to recognize TSAs and eliminate tumor cells; this therapy involves specific and non specific stimulators are known as______
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active immunotherapy
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a mass of approx. 1cm in diameter at clinical horizon for detection has at least ___tumor cells
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10^9
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when administered after cranial radiation_____can lead to increased brain tissue drug concenrations and produce leukoencephalopathy
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methotrexate
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each of teh following agents belogn to the corticosteroids group EXCEPT
a. prednisone b. tamoxifen c. dexamethasone d. hydrocortisone |
tamoxifen
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N/V resutling fromt eh physiologic effects of chemo usually occur___hrs following teh chemotherpay tx
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3-6hrs
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