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36 Cards in this Set

  • Front
  • Back
What is a product of mixed acid fermentation that in some, but not all, bacteria may be split to two gas molecules?
Formic Acid
What compound is involved in the acquisition of iron by bacteria?
Siderophore
O-antigens are related to LPS, whereas mucoidy and K-antigens are related to what component?
Capsule
The system by which glucose gets into e. coli?
group translocation
During fermentation what compound is exhausted by the conversion of glucose to pyruvate and must be regenerated?
NAD
What part of a bacterium will allow a "smooth" colony, but when absent will show a "rough" colony?
O-antigen
What "chemical group" could form a long intramolecular bridge between L-lysine and D-alanine in the peptidoglycan of Gram+ bacteria?
Pentaglycine
A length of DNA coding for virulence factors that appears to have originated from a foreign source and is imbedded in the chromosome
Pathogenicity Island
What compound is used to get large hydrophilic precursors to the growing peptidoglycan?
Bactoprenol
What is the unusual fatty acid found in Lipid A?
Beta hydroxy myristic acid
Monobactam
blocks cell wall synthesis in Gram- aerobic bacteria
Quinolones
A broad spectrum antibiotic that inhibits replication via inhibition of DNA gyrase, works well against gram- bacteria and resistant strains
Tetracycline
inhibits protein synthesis by reversibly binding the 30s ribosomal subunit, it is broad spectrum and the drug of choice against RMSF and chlamydia
Polymyxin
disrupts bacterial cell walls by targeting ethylolamine
Cycloserine
Inhibits bacterial cell wall synthesis by stopping the production of d-alanyl-d-alanine subunit
Chloramphenicol
inhibits protein synthesis by reversibly binding the 50S subunit (blocks the bond at the peptidyl site); it is broad spectrum and can cause irreversible aplastic anemia
Bacitracin
Inhibits Cell-wall synthesis by preventing the carrier from adhering the subunit
Metronidazole
DNA fragmenter, must be taken up and reduced first, it is used against parasites and anaerobes
Oxozolidonones
targets Gram+, affects the initiation complex in protein synthesis
Daptomycin
a cyclic lipopeptide that targets cell membranes
Polyene/Amphotericin B
an antifungal that disrupts the cell membrane
Penicillin
bactericidal, inhibits cell wall synthesis by disrupting transpeptidase cross linking, sensitive to beta lactamase
Ampicillin/Amoxicillin
Penicillins that are broader spectrum
Methicillin/Oxacillin
Penicillins that are beta lactamase resistant
Carbemicillin
Penicillin that is extended spectrum
Spectinomycin
bacteriostatic, inhibits bacterial protein synthesis by binding the 30S ribosomal subunit
Rifampin/Rifamycin
inhibits bacterial RNA polymerase
Griseofulvin
an antifungal that inhibits nucleic acid synthesis in fungi by inhibiting fungal microtubules
Lincomycin/Clindamycin
inhibits protein synthesis by binding 50S subunit, can target bacteroides causing pseudomebranous colitis and an overgrowth of c. diff
Macrolides/Eryhtromycin
target gram+, blocks protein synthesis by binding 50S subunit, effective against URIs like mycoplasma pneumoniae and Legionnaire's, Azithromycin and Clarithromycin are derivatives
Cephalosporins
block cell wall synthesis by blocking transpeptidase cross linking, less potent than penicillin but broader spectrum and more resistant to beta lactamase
Carbapenems
imipenem and meropenem, inhibits cell wall synthesis, broad-spectrum and beta-lactamase resistant
Aminoglycosides
blocks protein synthesis by blocking 30S subunit, broad spectrum but ineffective against anaerobes, strepto-, genta-, neo-, kana-, and tobramycin
Tigecycline
derived from tetracycline, 1st glyclcyline antibiotic, broad spectrum and effective against MRSA, probably binds 30S ribosome
Imidizole
targets ergosterol in fungal cell membrane
Vancomycin
inhibits cll wall synthesis by blocking lipid carrier