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11 Cards in this Set
- Front
- Back
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___ is composed of 2 heavy chains and 2 light chains
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Fab
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___ is composed of only heavy chain residues
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Fc
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Cmu and Cdelta are looped out to make Ig___
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G
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In isotype switch after primary response, Ig___ is switched to Ig__
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M; G
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Ig___ is maternally transferred
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G
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What are the genes responsible for recombination of J and v segments?
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RAG-1 and RAG-2
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What region determines the isotype of an immunoglobin?
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constant region of heavy chain
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Are the variable regions of IgM and IgD in mature B cell the same or different?
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the same (allows for binding to the same antigen)
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___ cells secrete cytokines that influence isotype switching
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T
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What is the role of TdT in creating antigen binding sites?
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Increases Ab diversity by randomly inserting nucleotides into gene segments
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isotype switching and somatic hypermutation occur via _____________
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AID (activation induced cytidine deaminase)
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