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20 Cards in this Set

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what are the major biological roles for complement?
opsonize, disrupt microbial membranes, recruit inflammatory cells and remove immune complexes
What is the focal complement protein?
C3
Pathogen surface creates a local environment conductive to complement activation in the _____________ pathway
alternate
Mannose-binding lectin binds to pathogen surface in the ___________ pathway
lectin
C-reactive protein binds to specific antigen on pathogen in the ____________ pathway
classical
which C3 convertase initiates the alternate pathway?
iC3Bb
which C3 covertase is attached to the pathogen surface?
C3bBb
List the components of the MAC
C5b, C6, C7, C8, C9
The lectin pathway acts on C__ to make a C3 convertase
4
MASP1, MASP2 and MBL make up the protease of the ___________ pathway
lectin
What are the roles of C1 complement?
bind to Fc region of antibody and form C4bC2a C3 covertase (classical pathway)
Which complement proteins are anaphylatoxins?
C3a, C4a, C5a
Which complement protein is a chemotactic factor for neutrophils?
C5a
Which complement factor is opsonin?
C3b
______ on macrophage binds to C3b on bacterium
CR1
What is the role of CD59, DAF and C1INH?
slow down/ inhibit complement activity
Which complement receptors have a specificity for iC3b and what is their related function?
CR1, CR3 and CR4; stimulate phagocytosis
what complement receptors are found on mast cells, endothelial cells and phagocytes?
C5a receptor and C3a receptor
Which complement receptors can be found on B cells?
CR1 and CR2
Which complement receptor has specificity toward epstein-barr virus?
CR2