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20 Cards in this Set
- Front
- Back
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what are the major biological roles for complement?
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opsonize, disrupt microbial membranes, recruit inflammatory cells and remove immune complexes
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What is the focal complement protein?
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C3
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Pathogen surface creates a local environment conductive to complement activation in the _____________ pathway
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alternate
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Mannose-binding lectin binds to pathogen surface in the ___________ pathway
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lectin
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C-reactive protein binds to specific antigen on pathogen in the ____________ pathway
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classical
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which C3 convertase initiates the alternate pathway?
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iC3Bb
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which C3 covertase is attached to the pathogen surface?
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C3bBb
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List the components of the MAC
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C5b, C6, C7, C8, C9
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The lectin pathway acts on C__ to make a C3 convertase
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4
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MASP1, MASP2 and MBL make up the protease of the ___________ pathway
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lectin
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What are the roles of C1 complement?
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bind to Fc region of antibody and form C4bC2a C3 covertase (classical pathway)
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Which complement proteins are anaphylatoxins?
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C3a, C4a, C5a
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Which complement protein is a chemotactic factor for neutrophils?
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C5a
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Which complement factor is opsonin?
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C3b
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______ on macrophage binds to C3b on bacterium
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CR1
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What is the role of CD59, DAF and C1INH?
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slow down/ inhibit complement activity
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Which complement receptors have a specificity for iC3b and what is their related function?
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CR1, CR3 and CR4; stimulate phagocytosis
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what complement receptors are found on mast cells, endothelial cells and phagocytes?
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C5a receptor and C3a receptor
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Which complement receptors can be found on B cells?
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CR1 and CR2
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Which complement receptor has specificity toward epstein-barr virus?
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CR2
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