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12 Cards in this Set
- Front
- Back
________________: Any gene of viral or cellular origin that is thought to contribute to malignant transformation of cells when mutated or abnormally expressed.
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oncogene
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_______________: any oncogene normally found in the mammalian genome
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proto-oncogene
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________________: Genes whose protein product suppresses cancer. Inactivation or loss of these genes contribute to cancer transformation.
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tumor-suppressor genes
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What are the three methods of tumor escape discussed in class?
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Lack of immunogenecity, Tumor-induced immunosuppression, loss of tumor MHC antigens
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What is the #1 immune response to tumors?
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cytotoxic T-cells
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How does adoptive cellular therapy work?
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isolate lymphocytes from patient, expand culture in vitro w/ IL-2, reinject into patient
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Where will you find leukemias? lymphomas?
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bone marrow; tissues
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a _________ is a monoclonal band seen on electrophoresis and is used in detecting myeloma
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paraprotein
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__________ is a cancer of plasma cells
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myeloma
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Are there more T-cell or B-cell neoplasms?
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more B-cell neoplasms
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__-cells express CD19 while ___-cells express CD5
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B; T
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Negative cell surface Ig but positive cytoplasmic Ig would lead you to believe cancer is present in what type of cell?
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Immature B-cell
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