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12 Cards in this Set

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________________: Any gene of viral or cellular origin that is thought to contribute to malignant transformation of cells when mutated or abnormally expressed.
oncogene
_______________: any oncogene normally found in the mammalian genome
proto-oncogene
________________: Genes whose protein product suppresses cancer. Inactivation or loss of these genes contribute to cancer transformation.
tumor-suppressor genes
What are the three methods of tumor escape discussed in class?
Lack of immunogenecity, Tumor-induced immunosuppression, loss of tumor MHC antigens
What is the #1 immune response to tumors?
cytotoxic T-cells
How does adoptive cellular therapy work?
isolate lymphocytes from patient, expand culture in vitro w/ IL-2, reinject into patient
Where will you find leukemias? lymphomas?
bone marrow; tissues
a _________ is a monoclonal band seen on electrophoresis and is used in detecting myeloma
paraprotein
__________ is a cancer of plasma cells
myeloma
Are there more T-cell or B-cell neoplasms?
more B-cell neoplasms
__-cells express CD19 while ___-cells express CD5
B; T
Negative cell surface Ig but positive cytoplasmic Ig would lead you to believe cancer is present in what type of cell?
Immature B-cell