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19 Cards in this Set
- Front
- Back
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What are the 5 cytokine families?
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Colony-stimulating factors, Interferons, Interleukins, TNF family, Unassigned (eg TGF-beta)
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which CSF cytokine stimulates the growth and differentiation of myelomonocytic cell lineages, particularly dendritic cells?
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GM-CSF (she made a big deal of this one in class)
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which CSF cytokine promotes neutrophil development and differentiation?
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G-CSF
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which CSF promotes growth of cells of the monocyte lineage?
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M-CSF
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Which are the type I interferons? the type II?
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IFN-alpha and beta; IFN-gamma
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DC's produce which type of interferons?
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Type I
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T cells and NK cells produce which type of interferons?
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Type II
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IFN-_____ is the most important cytokine involved in macrophage activation
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gamma
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Which IFN is a central player in lupus?
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alpha
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Th___ secretes IL-4 and IL-5
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2
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Th___ secretes IL-2 and INF-gamma
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1
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___________ is the major cytokine involved in Rheumatoid Arthritis
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TNF-alpha
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_________ is the cytokine produced by monocytes and T cells that is anti-inflammatory, induces isotype switching to IgA and has a role in generating Tregs
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TGF-beta
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_________ is the cytokine produced by T cells that inhibits macrophage migration and stimulates macrophage activation
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MIF
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IL-4 is known to primarily induce isotype switching to Ig__
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E
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IL-__ augments IgA production
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5
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T____ cell dysregulation can aid in pathenogenesis of IBD
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reg
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the _______ mechanism of apoptosis includes the release of serine proteases, perforin, and granulysin
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major
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What happens in ALPS?
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Fas-mediated apoptosis is absent, lymph nodes swell and auto-immune attacks occur
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