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24 Cards in this Set

  • Front
  • Back
Acetylcholine
.
.
.
peripheral efferent nerves
somatic
autonomic
-sympathetic
-parasympathetic
norepi
.
.
.
cholinergic functions
review
biosynthesis of Ach
SER--(ser decarboxylase)--(Choline N-methyl transferase)--CHOLINE--(Choline acetyl transferase)--ACH
rate-limiting step
choline to ACh
(inbtwn. is glycolosis & pyruvate oxidation)
CHOLINE is limiting reagent, recycled from synapse
storage of ACh
newly made--storage vesicles, located at presynaptic nerve endings
any free ACh--immed. hydrolyzed by AChE
Storage/transport inhibitor
vesamicol
synapsin
synapsin I binds vesicles and inhibits ACh release
INHIB by botulinum toxin
Metabolism ACH
synaptic cleft-3 x 10^6
receptors- 2 x 10^7 receptors
AChE
RECEPTORS AND SUBTYPES
.
.
.
.
.
.
.
muscarine
.
.
.
.
.
.
nicotine
.
.
.
.
.
.
MUSCARINIC
. slow onset
. prolonged duration of action
. excitatory or inhibitory
. postganglionic PS neurons
. autonomic presynaptic neurons
. GCPR
. agonist: muscarine
. antagonist: atropine
NICOTINIC
. rapid onset
. short duration
. excitatory
LOCATION
. autonomic postsynaptic
. autonomic ganglia
. somatic neuromuscular junctions
.ligand-gated ion channels
. agonist: nicotine
. antagonist: curare
muscarine poisoning effects
. salivation, perspiration, lacrimation
. larger dose: abdominal pain, blurred vision, difficulty breathing, death (rare)
nicotine poisoning effects
. insecticide, absorbed through skin
. initial stimulation then higher doses lead to poisoning and death
Muscarinic receptors
M1, M3, M5
Gq family (PLC, DAG, PKC, IP3, Ca)--increases all
Muscarinic receptors
M2, M4
Gi family (inhibit AC, dec. cAMP)
LOOK AT MUSCARINIC GRAPH IN NOTES
MEMEMEMEMEME
hemicholinium
blocks choline reuptake at the synapse
neurotoxins
botulinum, tetrodotoxin, saxitoxin, latrotoxin
indirect-acting
REVERSIBLE: carbamates
IRREVERSIBLE: phosphates
Nicotinic receptor sub-type
N1
LOCATION: skeletal muscle
AGONISTS: ACh & nicotine, PMTA
ANTAGONISTS: decamethonium
Nicotinic receptor sub-type
N2
LOCATION: autonomic ganglia
AGONISTS: ACh & nicotine, DHPP
ANTAGONISTS: hexamethonium