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17 Cards in this Set

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Ergot alkaloids
.
.
.
properties of ergot alkaloids
alpha 1 antagonism= vasoconstriction,
induces labor, hallucinations
major alkaloid
ergotamine- different effects and receptor types
ergot tx
migraine, contract uterine smooth muscle (induce labor, abortion)
LSD
.
.
.
methylsergide
5HT 1,2,3,4 antag and alpha agonist
prophl. tx for migraine
bromocriptine
.
.
.
tx: DA d2 agonist, dec prolactin secretion from pituitary
fluoxetine
.
.
.
paroxetine
.
.
.
sertraline
.
.
.
SSRI's
all block 5HT reuptake at synapse
tx: depression
serotonin syndrome
hyperthermia, muscle rigidity, myoclonus
(If MAOI & SSRI)
sibutramine
x BBB
.
.
.
sibutramine SE's
inc BP, insomnia, constipation
*diastomeric mixture
fenfluramine
.
.
.
fenfluramine se's
decrease in appetite (like amphetamines), inc lipoph
fen-phen
fenfluramine & phentermine
.
.
.

.
problems: fatal pulm HTN, excess catech. & 5HT in periphery