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17 Cards in this Set
- Front
- Back
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Ergot alkaloids
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properties of ergot alkaloids
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alpha 1 antagonism= vasoconstriction,
induces labor, hallucinations |
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major alkaloid
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ergotamine- different effects and receptor types
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ergot tx
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migraine, contract uterine smooth muscle (induce labor, abortion)
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LSD
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methylsergide
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5HT 1,2,3,4 antag and alpha agonist
prophl. tx for migraine |
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bromocriptine
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. . tx: DA d2 agonist, dec prolactin secretion from pituitary |
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fluoxetine
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paroxetine
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sertraline
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SSRI's
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all block 5HT reuptake at synapse
tx: depression |
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serotonin syndrome
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hyperthermia, muscle rigidity, myoclonus
(If MAOI & SSRI) |
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sibutramine
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x BBB
. . . |
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sibutramine SE's
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inc BP, insomnia, constipation
*diastomeric mixture |
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fenfluramine
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fenfluramine se's
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decrease in appetite (like amphetamines), inc lipoph
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fen-phen
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fenfluramine & phentermine
. . . . problems: fatal pulm HTN, excess catech. & 5HT in periphery |
