Medchem Test 2 - Spasmolytics

Front 1

spasticity appears to involve damage to ___?___ pathways in the spinal cord

Back 1

descending

Front 2

spasmolytic drugs are ___?___ in treating cerebral palsy and spinal cord injuries

Back 2

not effective

Front 3

Propanediol carbamates are primarily centrally acting ___?___

Back 3

sedatives

Front 4

adding a carbamate to a drug does what to metabolism and half life?

Back 4

slows metabolism and increases half life

Front 5

Dr. Joe Sam from UM developed this SkMR that is metabolized through conjugation.

Back 5

Chlorzoxazone or Benzoxazole

Front 6

Orphenadine citrate (ethanolamine) MOA is?

Used to treat?

Back 6

unknown but it is an anticholinergic

Used to tx muscle spasm assoc. with acute conditions

Front 7

Cyclobenzaprine not only acts as a SkMR but also as a ?

Back 7

CNS depressant

Front 8

Second generation SkMR that can treat spasticity in patients with spinal lesions include ?

Also used to treat paraplegia, quadriplegia, and MS

Back 8

Diazepam (benzodiazepines)

Front 9

This drug is a GABA derivative that is at least as effective as diazepam but with less sedation?

Back 9

Baclofen

Front 10

Baclofen acts as a __?__

Back 10

GABAb receptor agonist

Front 11

Hydantion direct acting SkMR whose MOA is known and it works in the peripheries

Back 11

Dantrolen Sodium

Front 12

Dantolen sodium works by ?

Back 12

reducing muscle strength by interfering with muscle excitation-contraction coupling by suppressing Ca release

Front 13

Imidazoline related to anti HTN drug clonidine that is a central alpha 2 agonist that increases presynaptic inhibition of motor neurons

Back 13

tizanidine hcl