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5 Cards in this Set
- Front
- Back
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How to make Zinc binding group more orally available?
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Answer: progdrugs; esterification of carboxylate and phosphinate. Cleaved by esterases to parent drug
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Enalapril is bioactivated by what enzyme?
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Answer: esterase in liver; from enalapril to enalaprilat
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Glucoronidation can be affected by steric factors associated with the ____ system.
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Answer: ring;
ACEI metabolism |
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Peptide bonds are:
a. planar b. sp3 hybridized c. freely rotate around |
Answer: A
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Peptidomimetics:
a. mimic the action of peptides b. MW > 700 daltons c. low bioavailability d. decrease duration of action |
Answer: A
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