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19 Cards in this Set
- Front
- Back
CK lab test
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Creatine kinase
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3 Kinds of CK isoenzymes
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CK-MM (skeletal muscle)
CK-BB (brain tissue) CK-MB (Cardiac Muscle) |
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Most specific enzyme
First enzyme level to increase after AMI |
CK
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Enzyme levels increase within a few hours and peak within 24 hours
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CK
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If the area is reperfused, ( due to thrombolytic therapy or PCI) what effect does it have on CK levels?
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Ck levels peak earlier
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Total CK
1. earliest increase 2. peak 3. returns to normal |
1. 3-6 hours
2. 24-36 hours 3. 3 days |
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Analyzed in patients who have delayed seeking medical treatment becasue blood levels peak within 2-3 days.
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Lactic Dehydrogenase
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CK-MB
1. earliest increase 2. peak 3. returns to normal |
1. 4-8 hours
2. 12-24 hours 3. 3-4 days |
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CK (mass assay)
1. earliest increase 2. peak 3. returns to normal |
1. 2-3 hours
2. 10-18 hours 3. 3-4 days |
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Newer cardiac lab tests with faster results
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Myoglobin and Triponin
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heme protein (helps transport oxygen) with a small molecular weight causing it to be rapidly released from damaged tissue and accounts for its early increase
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Myoglobin
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Found in cardiac and skeletal muscle
Renal or musculoskeletal disease |
Myoglobin
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Not very specific in indicating an acute cardiac event however a negative result is an excellent parameter to rule out an AMI
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Myoglobin
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Myoglobin
1. earliest increase 2. peak 3. returns to normal |
1. 1-3 hours
2. 4-12 3. within 12 hours |
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protein found only in cardiac muscle (in myocardium)
regulates myocardial contractlie process |
Triponin
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3 isomers of triponin
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1. C
2. I 3. T I and T are specific cardiac muscle |
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Reliable and critical markers of acute MI
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triponin
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triponin
1. earliest increase 2. peak 3. return to normal |
1. 3-4 hours
2. 4-24 3. 1-3 weeks |
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Pathology of cardiac biomarkers
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Enzymes are released from injured cells when cell membrane rupture
certain isoenzymes come only from myocardial cells and are released when those cells are damaged by sustained hypoxia or trauma that results in infarction the isoenzymes leak into the interstitial spaces of the myocardium and are carried into the general circulation by the lymphatic system and the coronary circulation, resulting in elavated serum enzyme concentrations Diferent enzymes move into the blood at varying periods after an MI, enzyme levels should be tested in relation to the time of onset of chest discomfort or other symptoms |