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19 Cards in this Set

  • Front
  • Back
CK lab test
Creatine kinase
3 Kinds of CK isoenzymes
CK-MM (skeletal muscle)
CK-BB (brain tissue)
CK-MB (Cardiac Muscle)
Most specific enzyme
First enzyme level to increase after AMI
CK
Enzyme levels increase within a few hours and peak within 24 hours
CK
If the area is reperfused, ( due to thrombolytic therapy or PCI) what effect does it have on CK levels?
Ck levels peak earlier
Total CK
1. earliest increase
2. peak
3. returns to normal
1. 3-6 hours
2. 24-36 hours
3. 3 days
Analyzed in patients who have delayed seeking medical treatment becasue blood levels peak within 2-3 days.
Lactic Dehydrogenase
CK-MB
1. earliest increase
2. peak
3. returns to normal
1. 4-8 hours
2. 12-24 hours
3. 3-4 days
CK (mass assay)
1. earliest increase
2. peak
3. returns to normal
1. 2-3 hours
2. 10-18 hours
3. 3-4 days
Newer cardiac lab tests with faster results
Myoglobin and Triponin
heme protein (helps transport oxygen) with a small molecular weight causing it to be rapidly released from damaged tissue and accounts for its early increase
Myoglobin
Found in cardiac and skeletal muscle
Renal or musculoskeletal disease
Myoglobin
Not very specific in indicating an acute cardiac event however a negative result is an excellent parameter to rule out an AMI
Myoglobin
Myoglobin
1. earliest increase
2. peak
3. returns to normal
1. 1-3 hours
2. 4-12
3. within 12 hours
protein found only in cardiac muscle (in myocardium)
regulates myocardial contractlie process
Triponin
3 isomers of triponin
1. C
2. I
3. T
I and T are specific cardiac muscle
Reliable and critical markers of acute MI
triponin
triponin
1. earliest increase
2. peak
3. return to normal
1. 3-4 hours
2. 4-24
3. 1-3 weeks
Pathology of cardiac biomarkers
Enzymes are released from injured cells when cell membrane rupture
certain isoenzymes come only from myocardial cells and are released when those cells are damaged by sustained hypoxia or trauma that results in infarction
the isoenzymes leak into the interstitial spaces of the myocardium and are carried into the general circulation by the lymphatic system and the coronary circulation, resulting in elavated serum enzyme concentrations
Diferent enzymes move into the blood at varying periods after an MI, enzyme levels should be tested in relation to the time of onset of chest discomfort or other symptoms