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22 Cards in this Set
- Front
- Back
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Mechanism of action: streptomycin |
Protein synthesis inhibitor |
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Mechanism of action: isoniazid |
Inhibitor of mycolic acid sythesis |
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HIV-1 infection of a cell events |
1. binding CD4 receptors by gp120 2. Binding to CCR-5 3. Entry into cell mediated by gp-41 4. Uncoating of the virus 5. Synthesis of DNA by reverse transcriptase 6. integration into human DNA 7. Transcription 8. processing of RNA 9. Translation 10. Action of viral protease 11. Assembly of virus 12. Maturation of virus particles and exit |
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Chemotherapeutic dosing principles: |
drugs more beneficial if major toxicities are nonoverlapping |
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Which diagnostic methods can determine growth of solid tumors on the earliest stage? |
Positron emitting tomography (PET) |
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Which type of cancer is most susceptible for chemotherapy? |
Lymphoma |
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What factors complicate radiotherapy of solid tumors? |
Hydroxia - under hypoxic conditions efficiency of free radical damage of DNA is greatly decreased. |
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Anticancer drug that is also used to treat psoriasis and rheumatoid arthritis. |
Methotrexate |
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Does not have direct vesicant effects: |
Cyclophosphamide - is a prodrug that is slowly converted into an active substance |
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Antimycobacterial agent NOT absorbed orally: |
Streptomycin |
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Which of these agents can not be used for treatment of CNS tuberculosis |
Streptomycin |
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Mechanism of action: fluoroquinolones |
Topoisomerase inhibitor |
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Mechanism of action Chloramphenicol |
Protein synthesis inhibitor |
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Mechanism of action aztreonam |
Cell wall synthesis inhibitor |
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Inhibits bacterial cell Wall synthesis |
Cephalosporins |
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Ototoxicity and nephrotoxicity associated with these antibiotics |
Aminoglycosides |
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Group of endogenous protein that exhibit antiviral activities |
Interferon |
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Likely to promote drug drug interactions with cytochrome p450 drug metabolizing system |
Saquinavir, ritonavir, indinavir |
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Which types of drugs will be able of selective inhibition of malaria |
Inhibitor of dihydrofolate reductase |
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Cellular mechanism of resistance to the action of methotrexate |
Decrease transport and increased production of dihydrofolate reductase |
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Anticancer drug that also used to treat psoriasis and rheumatoid arthritis |
Nitrosoureas |
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Indicate which of antiviral drug regimens below should be most suitable for HIV treatment |
Nucleotide reverse transcriptase inhibitors and protease inhibitors |
