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5 Cards in this Set
- Front
- Back
Tetracyclines
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1. lack of transport into bacterial cell (altered memb perm -ompC:ompF
2.active-transport out of cell (extrusion pumps) a)ATPase type pump (tet pump) b)H+ gradient driven pump (mdr pump) |
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Sulfonamides
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1. more paba synthesis
2. ready-made products 3. alteration in dihydropteroate synthase 4. membrane permeability 5. ATP-dependent efflux transport proteins |
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Fluoroquinolones
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1.membrane permeability
2.ATP-driven efflux pumps produced by gram + 3.alteration of topo II -gyr A mutation decrease binding with drug -gyr B mutation alter binding of ATP 4.alteration of tope IV -par C and par E region mutations |
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Linezolid
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point mutation and modification of RNA sequence at binding site in 23S fragment of 50S ribosomal subunit
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Non-HIV antivirals
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mutations in transmembrane region of M2 protein alter drug binding
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