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5 Cards in this Set

  • Front
  • Back
Tetracyclines
1. lack of transport into bacterial cell (altered memb perm -ompC:ompF

2.active-transport out of cell (extrusion pumps)

a)ATPase type pump (tet pump)
b)H+ gradient driven pump (mdr pump)
Sulfonamides
1. more paba synthesis
2. ready-made products
3. alteration in dihydropteroate synthase
4. membrane permeability
5. ATP-dependent efflux transport proteins
Fluoroquinolones
1.membrane permeability
2.ATP-driven efflux pumps produced by gram +
3.alteration of topo II
-gyr A mutation decrease binding with drug
-gyr B mutation alter binding of ATP
4.alteration of tope IV
-par C and par E region mutations
Linezolid
point mutation and modification of RNA sequence at binding site in 23S fragment of 50S ribosomal subunit
Non-HIV antivirals
mutations in transmembrane region of M2 protein alter drug binding