Med Chem Lecture 1

Front 1

Endocrine Organssecrete

Pituitary gland---secrete?

Back 1

ACTH, TSH, FSH, LH, prolactin; ADH and oxytocin

Front 2

Endocrine Organssecrete

Pancreas—

Back 2

insulin and glucagon

Front 3

Endocrine Organssecrete

Thyroid—

Back 3

triiodothyronine and thyroxine

Front 4

Endocrine Organssecrete

Parathyroid—

Back 4

calcitonin

Front 5

Endocrine Organssecrete

Reproductive—

Back 5

estrogen, progesterone, testosterone

Front 6

Types of Hormones

Peptide hormones—?

Steroid hormones—?


Tyrosine derivatives?

Back 6

Peptide hormones—growth hormone, insulin

Steroid hormones—
glucocorticocorticoids, estrogens

Tyrosine derivatives—thyroid hormone

Front 7

Water soluble hormones?

Lipid Soluble hormones?

Back 7

Water soluble hormones (proteins, insulin) circulate in free form; lipid soluble hormones use a carrier/binding protein

Front 8

Receptors for the water soluble hormones found?

Back 8

Receptors for the water soluble hormones

are found on the surface of the target cell, on the plasma membrane.
These types of receptors are coupled to
various second messenger systems which
mediate the action of the hormone in the
target cell.

Front 9

Receptors for the lipid soluble hormones found?

Back 9

Receptors for the lipid soluble hormones reside in

the nucleus (and sometimes the cytoplasm) of the target cell.
Because these hormones can diffuse through the lipid bilayer of the plasma membrane, their receptors are located on the interior of the target cell

Front 10

Endocrine Disease

Congenital Adrenal Hyperplasia?

Back 10

Congenital Adrenal Hyperplasia
It is an autosomal recessive diseases
Defects in steps of the synthesis of cortisol from cholesterol by the adrenal glands. Most of these diseases involve excessive or deficient production of sex steroids and can pervert or impair development of primary or secondary sex characteristics in affected infants, children, and adults.

Front 11

Cushing’s Syndrome ?

Back 11

Cushing’s Syndrome
weight gain, particularly of the trunk and face with sparing of the limbs (central obesity), "moon face",
reduced libido, impotence, amenorrhoea and infertility.
from euphoria to frank psychosis. Depression and anxiety, including panic attacks, are common.
hypertension (due to the aldosterone-like effects) and insulin resistance, leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus.

Front 12

Grave’s Disease

Back 12

Grave’s Disease
Production of autoantibodies that bind to the TSH receptor, which is present on the follicular cells of the thyroid (the cells that produce thryoid hormone). These antibodies activate the cells in the same fashion as TSH itself.