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11 Cards in this Set
- Front
- Back
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Morphine |
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Heroin 2x APM More lipophilic than morphine, higher cns pen. |
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Codeine 1/12th APM |
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Hydrocodone 7,8 double bond reduced from codeine More potent analgesic and antitussive
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Hydromorphone 8X the mu agonist potency of morphine 5X APM Same addiction potential as morphine |
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Oxycodone Same anagesic effects as morphine Low antitussive due to -OH on 14 |
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Oxymorphone 75x APM Low antitussive due to -OH on 14 |
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Naloxone Pure opioid antagonist Antagonist at all 3 receptors |
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Naltrexone 2x as potent as Naloxone |
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Methylnaltrexone Charged, does not penetrate cns Used for constipation, not opioid withdrawal |
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Nalmefene
More lipophilic, and has a longer half-life (11h) Better for counteracting the adverse effect of long acting opioids like methadone, but may also prolong withdrawal symptoms because of very slow dissociation from mu receptor |
