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24 Cards in this Set
- Front
- Back
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Conventional antipsychotics
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Block DA receptors; more extrapyramidal (motor) adverse effects; more effect on positive than negative S/S
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Atypical antipsychotics
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Blocks DA receptors but potent blockade of 5HT receptors; fewer extrapyramidal effects; effective for positive and negative S/S
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Phenothiazines
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Block dopamine receptors, especially D2
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Chlorpromazine (Thorazine)
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Low potency phenothiazine; low extrapyramidal effects
(block dopamine receptors, D2) |
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Thioridazine (Mellaril)
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Low potency phenothiazine; low extrapyramidal effects
(block dopamine receptors, D2) |
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Thiothixene (Navane)
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High potency phenothiazines
(block dopamine receptors, D2) |
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Fluphenazine (Prolixin)
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High potency phenothiazines
(block dopamine receptors, D2) |
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Prochlorperazine (Compazine)
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Non-psychiatric phenothiazines; blocks dopamine receptors
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Promethazine (Phenergan)
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Non-psychiatric phenothiazines; blocks dopamine receptors
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Non-phenothiazines MOA
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Block dopamine receptors, epecially D2
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Haldoperidol (Haldol)
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High potency non-phenothiazines; less sedation and anticholinergic but high extrapyramidal effects
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Droperidol (Inaspine)
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High potency non-phenothiazines;non-psychiatric usage
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Resperidone (Risperdal)
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Atypical antipsychotics;
Binds 5HT2, DA2 |
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Other uses of Resperidone (Risperdal)
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Bipolar, OCD,Tourette's, dementia, conduct disorders
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Olanzapine (Zyprexa)
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Atypical antipsychotics; weight gain prominent
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Clozapine (Clozaril)
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Atypical antipsychotics; blocks DA4 but also 5HT2 alpha 1 and H1; few extrapyramidal but agranulocytosis occurs in 2%; also seizures in 2%
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Cocaine
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Block reuptake of DA, NE, 5HT; local anesthetic; vasoconstriction
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Amphetamines
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Block catecholamine uptake and causes release of dopamine; causes permanent degeneration of dopaminergic neurons
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MDMA
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Methylenedioxy-derivatives of methamphetamine; selective serotonergic neurotoxin that causes degeneration of 5HT
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GHB
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Powerful CNS depressants; anesthetic; derived from GABA; Inhibi centra DA release and mediate some effects through GABA receptor
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Ketamine
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Disociative anesthetic (catatonia, amnesia, analgesia w/o loss of consciousness); CV stimulant
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LSD
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Hallucinogens that cause perceptual distortion and mood changes; sympathetic and central stimulation; related to ketamine; causes detachment, disorientation, numbness, nystagmus, sweating, HTN
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Cannabinoids
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Active ingredient: THC; binding site is anandamide (found widespread in brain); euphoria, relaxation, poor concentration, laughter
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Dronabinal (Marinol)
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For N/V associated with chemotherapy; derivative of cannabinoids
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