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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What hormone controls the release of FSH and LH from the anterior pituitary?
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GnRH (released by hypothalamus)
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What hormones are produced by the ovaries?
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oestrogen and progesterone
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What is FSH required for
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Ovarian follicular development (GF)
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What is the function of LH
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Causes ovulation and development of CL
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GF release what?
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oestrogen
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CL releases what?
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Progesterone
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What are the 2 phases of mentsrual cycle?
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Follicular phase and leuteal phase
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What happens to levels of progesterone andf oestogen during the follicular phase?
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Oestrogen increases gradually and progesterone stays same
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What marks the start of the luteal phase?
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Rapid increase in LH
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What are 2 types of oral contraceptives available?
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- combined pill (oestrogen + progestin)
- progestin only pill |
progestin only used for women with high bp (higher failure rate)
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What is used instead of oestrogen in the combined pill?
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EE
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its orally active unlike oestrogen
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What is the MOA of EE in the combined pill?
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Inhibits FSH (-ve feedback) so GF development is supressed
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so ovulation doesnt occur
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What is the MOA of progestin in combined pill?
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Prevents secretion of LH
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so ovulation cant occur
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What are effects of the combined pill?
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- Delayed maturation of the endometrium
- increased viscocsity of cervical mucous (retard sperm mobility) |
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What are the effects of the progestin only pill?
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- Some inhibition of LH/FSH
- cervical mucous made inhospitable to sperm - hinders endometrium implantation |
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Anti progestins used for what?
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pregnancy termination
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What enzyme converts androgens to oestrogens?
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Aromatase
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MOA of antioestrogens?
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Antagonist of oestrogen at estrogen receptors in breast tissue (no transcription occurs as cofactors dont bind)
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estrogens binding to ERs are main stimulant for development of breast cancer tumours
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Other than antioestrogens what else can be used to prevent growth of breast cancer tumour?
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Aromatase inhibitors
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What happens to oestrogen levels during menopause and what is the effect of this on GF?
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decreased level and GF doesnt develop
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Hormone replacement theory in terms of menopause: describe
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conjugated oestrogen given to patient (oestrogen with sulfate group) eg. premarine
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