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8 Cards in this Set
- Front
- Back
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What are 3 stages of immunosurveillance of neoplasia?
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1. Elimination
2. Equilibrium 3. Escape |
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What are the 2 signals recieved by a CD8 cytotoxic T cell?
What signals help to "T-cell help" dendritic cells? |
1. MHC / TCR
2. CD28 / B7 CD40, CD40L "T cell Help" |
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Why can tumor cells not prime a CTL?
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Because tumor cells rarely express MCH or B7, therefore CD8 cells do not get both signals --> become anergic
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What therapy has been used wrt to CD40?
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Using a monoclonal antibody to stimulate CD40 and thus activate CD40 and reverse immune suppression
Hope is to drive T cell immunity |
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In the CD40 mAb therapy, what cell type was critical to a response?
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Macrophages
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What receptor is important in turning off the T cell?
How is this important in possible therapy? |
CTLA-4
Important in therapy because it is hoped by turning off CTLA-4, can stop immune suppression |
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What is the risk the immune therapies for cancer?
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Can induce autoimmunity
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What is the process for T cell infusion therapy for cancer?
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1. Remove the immune cells from blood
2. Engineer T cells to express chimeric antigen receptors (Express antibody for tumor) 3. Prepare cells for re-infusion 4. Give patient engineered T cells |
