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13 Cards in this Set

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-Albumin

Clinical implications
-hypoalbuminemia (low albumin) may be caused by liver disease,

-nephrotic syndrome, malnutrition and others.

-Hyperalbuminemia (high albumin) is almost always caused by dehydration.
-hypoalbuminemia (low albumin) may be caused by liver disease,

-nephrotic syndrome, malnutrition and others.

-Hyperalbuminemia (high albumin) is almost always caused by dehydration.


Globular Protein Transporter =
-Albumin
-Ceruloplasmin

Clinical implications
aceruloplasminemia:
characterized by hyperferritinemia with iron overload
Globular Protein Transporter =
-Ceruloplasmin
-Hemoglobin

Clinical implications
- decreased amount of hemoglobin molecules,
as in anemia or
decreased ability of each molecule to bind oxygen at the same partial pressure of oxygen, e.g.,
-hemoglobinopathies
-sickle-cell disease
-thalassemia.
- decreased amount of hemoglobin molecules,
as in anemia or
decreased ability of each molecule to bind oxygen at the same partial pressure of oxygen, e.g.,
-hemoglobinopathies
-sickle-cell disease
-thalassemia.

Globular Protein Transporter =
-Hemoglobin
-Myoglobin

Clinical implications
Myoglobin is a sensitive marker for muscle injury.
-released myoglobin is filtered by the kidneys and
- is toxic to the renal tubular epithelium,
-which may cause acute renal failure.
is a sensitive marker for muscle injury.
-released myoglobin is filtered by the kidneys and
- is toxic to the renal tubular epithelium,
-which may cause acute renal failure.

Globular Protein Transporter =
-Myoglobin
-Transferrin

Clinical implications
A patient with an increased serum transferrin level often suffers from iron deficiency anemia.
Pt w decreased plasma transferrin
can suffer from
-iron overload diseases
-protein malnutrition.
An absence of transferrin results from a rare genetic disorder known as atransferrinemia; a condition characterized by anemia and hemosiderosis in the heart and liver that leads to many complications, including heart failure
A patient with an increased serum transferrin level often suffers from iron deficiency anemia.
Pt w decreased plasma transferrin
can suffer from
-iron overload diseases
-protein malnutrition.
An absence of transferrin results from a rare genetic disorder known as atransferrinemia; a condition characterized by anemia and hemosiderosis in the heart and liver that leads to many complications, including heart failure


Globular Protein Transporter =
-Transferrin
-Transthyretin

Clinical implications
-TTR misfolding and aggregation is known to be associated with the amyloid diseases:
-senile systemic amyloidosis (SSA),
-familial amyloid polyneuropathy (FAP),
-familial amyloid cardiomyopathy (FAC).
-TTR misfolding and aggregation is known to be associated with the amyloid diseases:
-senile systemic amyloidosis (SSA),
-familial amyloid polyneuropathy (FAP),
-familial amyloid cardiomyopathy (FAC).

Globular Protein Transporter =
-Transthyretin
all of these that you R studying are what class of Protein =
Globular