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20 Cards in this Set
- Front
- Back
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T cell & B Cell main difference is =
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T cells have to have Ligands presented to them.
B cells do not. |
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two main subpopulations of T cells
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helper
cytotoxic lymphocytes (CTLs) |
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T lymphocytes recognize only =
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epitopes
mostly small peptides) that form complexes with special proteins of the cell surface of other cells (proteins of the major histocompatibility complex). |
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T-cells express
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CD2, CD3 and CD7 markers besides TCRs.
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Helper cells
responsible for = |
cytokine production,
interaction with B cells to promote their differentiation into plasma cells, activation of macrophages to phagocytose activation of cytotoxic lymphocytes, induction of an inflammatory reaction. |
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T-lymphocyte info
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1. Helper CD 4+ T cells that synthesize interleukin 2 (IL-2), interferon γ (IFN- γ) and tumor necrosis factor α (TNF- α) are called TH1 cells.
These interact with cytotoxic CD8 + T lymphocytes, NK cells and macrophages in cell mediated immune responses. These are essential for controlling intracellular pathogens such as viruses and certain microorganisms. 2. Helper CD 4+ T cells that synthesize IL-4, IL 5, IL 10 and IL 13 are called Th2 cells. They interact with B lymphocytes and are essential for initiating antibody–mediated immune responses that control extracellular pathogen |
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**CD4+ cells are _____ restricted =
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MHC II restricted
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***CD8+ cells are _____ restricted =
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MHC I restricted.
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Gamma /Delta (γδ) T lymphocytes represents a small population of T cells that have neither CD8 nor CD4 marker on their surface.
info only |
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Delayed (-type) hypersensitivity: role of CD4+ T cells
Innate or adaptive ? = |
adaptive
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____________ cells lack the marker molecules characteristic of B and T cells.
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natural killer lymphocytes
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One of the primary causes of the immunodeficiency syndrome known as AIDS involves the killing of
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helper T cells by the infecting retrovirus.
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_____ _______ ____ is a complex of chromosome 6 loci that encodes several proteins
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Major histocompatibility complex
(MHC) |
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Major histocompatibility complex
(MHC) Has chromosome 6 loci & encodes = 2ct |
class I MHC molecules
class II MHC molecules |
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Info for MHC
One individual, however, expresses only one set of class I proteins and one set of class II proteins; these proteins are unique to this individual. |
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All nucleated cells and platelets have
which MHC. |
class I proteins
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Diseases of the Immune system
The diseases of immune system can be broadly grouped into three types: |
allergic reactions.
immunodeficiency Autoimmune diseases |
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Diseases of the Immune system
allergic reactions. |
abnormal and intense reactions in an attempt to neutralize the effects of some antigens.
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Diseases of the Immune system
immunodeficiency |
genetic or infectious
may affect the complement system phagocytic acti development and function of B and T lymphocytes. |
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Diseases of the Immune system
Autoimmune diseases |
caused by T or B cell responses directed to self molecules.
Tissues are affected or even destroyed by cytotoxic T lymphocytes or autoantibodies. |
