Md1 Histology Block 3 Lymph 3 Part B

Front 1

The adult spleen is not essential to life, its loss makes the patient more vulnerable to
3ct

Back 1

anemia
leukopenia
overwhelming infections.

Front 2

organization of the spleen

Back 2

1. Capsule
2. Pulp

Front 3

Splenic Capsule Describe =

Back 3

dense C.T.
trabeculae
subdivide the organ into communicating compartments.
indented hilus
splenic artery
vein, lymphatic
nerves

Hint 3

Capsule: dense C.T. tissue capsule which extends trabeculae to subdivide the organ into communicating compartments. The capsule is indented at the hilus, through which splenic artery, vein, lymphatic vessels and nerves pass.

Front 4

Splenic Pulp Describe =

lacks a cortex and a medulla.

Back 4

a. red pulp
b. white pulp
c. marginal zone
white pulp and merges into red pulp.

Hint 4

White pulp, marginal zone and red pulp each possess a distinctive stroma made up of reticular meshwork. These meshwork consist of branched reticular cells, which synthesize and lie upon reticular fibers.

Front 5

Know the structure

Back 5

.

Front 6

White pulp
is a lymphatic tissue equivalent to the cortex of lymph nodes
3 parts

Back 6

1. periarterial lymphatic sheath
2. lymphatic nodules
T-lymphocytes are concentrated in the periarterial sheath and B-lymphocytes are concentrated in the nodules.

Front 7

Red pulp
The red pulp consists of

2

Back 7

a reticular meshwork (filtration bed) supplied by
A. arteries
B. drained by an anastomosing system of special veins called venous sinuses which drain into pulp veins.
The reticular meshwork
a branching system of
cords
splenic cords
complementary to
branching venous sinuses

Front 8

Red pulp contains =

Back 8

splenic sinusoids lined by elongated endothelial cells.

Splenic cords
also known as
cords of Billroth,
separate splenic sinusoids

macrophages, and blood cells

Front 9

In the cords

there are 4 fctns =

Back 9

-circulating monocytes
are trapped differentiate into =

-platelets are stored

-- Erythropoiesis

-destruction of
old damaged erythrocytes

Hint 9

macrophages

Front 10

2 types of blood circulations
have been described in the red
pulp:

Back 10

1 a closed circulation,
arterial vessels connect directly splenic sinusoids.

2 vessels opening directly into the red pulp spaces, entering through the interendothelial cell slits of the splenic sinusoids.

Front 11

Functions of the Spleen
2ct

Back 11

PHAGOCYTOSIS

IMMUNOLOGICAL DEFENSE

Front 12

Functions of the Spleen

Back 12

filter
phagocytose
mount immunological responses
blood-borne antigens. The spleen contains all the components (B and T lymphocytes,
APCs
phagocytic cells

Front 13

white pulp of the spleen
production site of =

Back 13

Lymphocytes

Front 14

white pulp
The hemoglobin they contain is broken down into several parts. =

Back 14

The protein, globin, is hydrolyzed to amino acids that are reused in protein synthesis.
Iron is released from heme and, joined to transferrin, is transported in the blood to the bone marrow, where it is reused in erythropoiesis.
Iron-free heme is metabolized to bilirubin, which is excreted in the bile by liver cells.

Front 15

Asplenia

Back 15

the Kupffer cells of the liver sinusoids complement the role of the white pulp in the detection and removal of bacteria circulating in blood.