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17 Cards in this Set
- Front
- Back
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binding to matrix
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requried for cell adhesion, spreading, and migration
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selective outgrowth of neurites is
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matrix dependent
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cell matrix interactions provide
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survival signal
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cells are surrounded by
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matrix
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cells bind specifically to
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ECM components via cell surface receptors
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integrins
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large family of transmembrane receptors taht bind ECM
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B subunit binds to
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talin which interacts with the cytoskeleton and integrates the outside with the inside of hte cell.
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integrins
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linkage between integrins and their ligand mediates adehsion between cells adn their environment
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tripeptide RGD
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facilitated binding of proteins to integrins
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integrins hav emajor role in
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integrating extracellular and intracellular environment, 2) adhesion of cells to their subtratum or other cells
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inside out signaling
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talin binding to cytoplasmic tails separates alpha and beta chain, inducing comformational change
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integrins-ecm interactions
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exert force and deform their substrate
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focal adhesions
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scattered, discrete sites for cell adhesion in their substratum
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RGD requried for
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platelet aggregation
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fibrinogen binds to integrin
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gluing platelets together
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clot buster drugs
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1) RGD peptide acts as competitive inhibitor to fibrinogen
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hemidesmosomes
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basal attachments of epithelial cells to the basement membrane in vivo( consistening keratin dense plauqe, linked to ECM by membrane spanning integrins.)
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