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5 Cards in this Set

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Does the degradation of glycogen to a form of lucose that can enter the glycolytic pathway require an input of energy?
There is no apparent requirement for energy. Since the equilibrium of the reaction is toward glycogen synthesis, the energy requirement is substituted by the high concentration of Pi in the liver cells
What are the three essentially irreversible reactions of glycolysis that must be circumvented in gluconeogenesis
Hexokinase, phosphofructokinase, pyruvate kinase
What is the energetic cost of the formation of fatty acyl-CoA?
Two high-energy phophodiester bonds are invested in activation of fatty acids. ATP goes to AMP and pyrophoshpate when fatty acids are converted to fatty acyl-CoA. Then pyrophosphate is hydrolyzed to two molecules of inorganic phosphate by pyrophosphatase.
At what steps are reduced electron carriers generated in the Beta oxidation of fatty acids?
Reduced electron carriers are generated at the acyl-CoA dehydrogenase step (FADH2) and at the B-hydroxyacyl-Coa dehydrogenase step (NADH)
Why do individuals with a mutation in the MCAD gene have high urinary levels of medium chain dicarboyxlic acids?
Individuals with a mutation in medium chain acyl dehydrogenase cannot oxidize medium chain fatty acids. Thus the medium chain fatty acyl-CoAs can be metablized in aberrant ways