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23 Cards in this Set

  • Front
  • Back
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Gravidity

Number of times woman has been pregnant

Parity

Number of times woman given birth to foetus >24 weeks GA (Live/Still)

GA - Gestational Age

1 G⬇1P⬇2


2 G⬇2P⬇0

1 Twins


2 2 x miscarriage

Nulliparous (nullip)

Not previously carried a pregnancy to 24 wks

Grand multiparity (grand multip)

4+ pregnancies to 24 wks

How is Delivery Date estimated? (EDD)

Last period 2 weeks before ovulation


That date is likely to be remembered.


EDD is 40 wks on

Human development is 38 wks


Pregnancy calculated as 40 wks

Key Phases of Development (4)

Fertilisation


Pre-embryo


Embryo


Foetus

FPEF

Before fertilisation (2)

Capacitation


Activation

CA

Capacitation

Post-ejaculation in f genital tract


Interacts with mucosa


7 hours


Removes glycoproteins and sterol from sperm membrane


Biochemical change only


Reversible on exposure to prostatic secretions

Activation

Occurs later in uterine tubes Acrosome reaction


Close to oocyte


Releases hydrolytic enzymes


Irreversible fusion

Polyspermy

More than 1 sperm fertilises the ovum


Inviable

How polyspermy is prevented (3)

Bare lost


Fast block


Slow block

200 million sperm per ml of ejaculate


200 make it to ampulla of uterine tube.


2-3s after fusion, ELECTRIC shock


10-60s after fusion, oocyte secretes lysosomes. Cortical reaction (WALL)


Zona reaction (Structural CHANGE to Zona pellucida)

Fertilisation window - 6 days!

Sperm survive 5 days.


Most fertile 1-2 days before and day of ovulation

Frequency of coitus affecting probability of fertilisation


Daily - 37%


Every 2 days - 33%


Once - 15%

Process of fertilisation (5 ordered)


Result of sperm entry (5)

Polar bodies

Ensures oocyte stays haploid until pronuclei combine

Form from uneven cell division in meiosis

Result of sperm entry (5)

Result of sperm entry

Microdeletion on chromosome 15


Father


Mother

Prader-Willi syndrome


Angelman's syndrome

Fertilisation key points (5/6)

Pre-embryo

Wks 1-2 Pre-implantation


Cell division period

Embryo

Wks 3-8


Organogenesis

Foetus

Wks 9-38


Growth

Key Phases of Development