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9 Cards in this Set

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Drug interaction with target dependent on (2)

Shape - determines 'ability'


Charge distribution - determines types of bonds that can form

Guess the strengths of bonds


(VdW, Cov, Ionic, H)

Van der Waals


Hydrogen


Ionic


Covalent

Further consideration (4)

Hydrophobicity


Ionisation of drug (pKa)


Conformation of target


Stereochemistry BRUFEN


Targets for drug action - target protein


(4 types)

1 Receptors


2 Ion channels


3 Enzymes


4 Carriers

1 beta-2-adrenoreceptors (Salbutamol)


2 V-gated Na+ channels (Lidocaine)


3 COX (Ibuprofen)


4 Proton pump (Omeprazole)

Agonist (At Receptor)

Activate the receptor

Antagonists (At Receptor)

Blocks action of agonist at receptor

Ion channels

Opening is blocked or modulated

Allosteric binding (GABA) increase enzyme functionality

Benzodiazepines

Cell injury activates... NSAIDs

Phospholipase A2 (Chops arachidonic acid) NSAID causes less cyclooxygenase which make the prostaglandins

End result is prostaglands