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9 Cards in this Set
- Front
- Back
- 3rd side (hint)
Drug interaction with target dependent on (2) |
Shape - determines 'ability' Charge distribution - determines types of bonds that can form |
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Guess the strengths of bonds (VdW, Cov, Ionic, H) |
Van der Waals Hydrogen Ionic Covalent |
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Further consideration (4) |
Hydrophobicity Ionisation of drug (pKa) Conformation of target Stereochemistry BRUFEN |
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Targets for drug action - target protein (4 types) |
1 Receptors 2 Ion channels 3 Enzymes 4 Carriers |
1 beta-2-adrenoreceptors (Salbutamol) 2 V-gated Na+ channels (Lidocaine) 3 COX (Ibuprofen) 4 Proton pump (Omeprazole) |
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Agonist (At Receptor) |
Activate the receptor |
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Antagonists (At Receptor) |
Blocks action of agonist at receptor |
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Ion channels |
Opening is blocked or modulated |
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Allosteric binding (GABA) increase enzyme functionality |
Benzodiazepines |
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Cell injury activates... NSAIDs |
Phospholipase A2 (Chops arachidonic acid) NSAID causes less cyclooxygenase which make the prostaglandins |
End result is prostaglands |