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38 Cards in this Set
- Front
- Back
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when is lithium used to treat mani
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prevention and treatment
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does lithium have a narrow therapeutic index
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yes
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lithium is eliminated renally like what other salt
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sodium
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what is the moa of lithium
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unknown, may decrease camp levels which decreases its activity, may inhibit dephosphorylation
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what are the adverse effects of lithium
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acne, seizures, visual disturbances, edema, ataxia, diabetes insipidis, hypothyroidism, tremors
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lithium adverse effects
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acne, seizures, visual disturbances, edema, ataxia, diabetes insipidis, hypothyroidism, tremors
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how does lithium cause drug induced diabetes insipidus
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uncoupling of the vasopressin V2 receptors in the kidney
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uncoupling of the vasopressin V2 receptors in the kidney
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how does lithium cause drug induced diabetes insipidus
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which drug is used to treat lithium induced nephrogenic diabetes insipidis
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amiloride
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amiloride
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drug used to induce nephrogenic diabetes insipidus
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how does lithium cause hypothyroidism?
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inhibition of 5'iodinase
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how does lithium cause hypothyroidism?
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inhibition of 5'iodinase
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5'iodinase does what
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converts T4 to T3
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converts T4 to T3
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5'iodinase does what
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cardiac anomaly in infants born to a woman on lithium
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ebsteins anomaly which is malformation of the tricuspid valve leaflets (partly attached to the fibrous tricuspid valve annulus partly atached to the right ventricular endocardium inferior displacement of the tricuspid valve leaflets
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cardiac anomaly in infants born to a woman on lithium
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ebsteins anomaly which is malformation of the tricuspid valve leaflets (partly attached to the fibrous tricuspid valve annulus partly atached to the right ventricular endocardium inferior displacement of the tricuspid valve leaflets
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cardiac anomaly in infants born to a woman on lithium
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ebsteins anomaly which is malformation of the tricuspid valve leaflets (partly attached to the fibrous tricuspid valve annulus partly atached to the right ventricular endocardium inferior displacement of the tricuspid valve leaflets
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what other meds may be used to treat manic
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carbamezipine, valproic acid, benzodiazepines, gabapentin, topiramite
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what other meds may be used to treat manic
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carbamezipine, valproic acid, benzodiazepines, gabapentin, topiramite
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what antihypertensive med for migrain prophylaxis
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propanolol
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give an example of the triptan drug classes
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sumatriptan, almotriptan, naratriptan rizatriptan zolmitriptan
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give an example of the triptan drug classes
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sumatriptan, almotriptan, naratriptan rizatriptan zolmitriptan
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moa of sumatriptan
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5-HT1d receptor agonist which causes vasoC in cranial arteries
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moa of sumatriptan
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5-HT1d receptor agonist which causes vasoC in cranial arteries
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moa of sumatriptan
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5-HT1d receptor agonist which causes vasoC in cranial arteries
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moa of sumatriptan
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5-HT1d receptor agonist which causes vasoC in cranial arteries
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why should sumatriptan be used with caution in a patient with angina
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can precipitate an anginla attack secondary to vasospasm of coronary arteries
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can precipitate an anginla attack secondary to vasospasm of coronary arteries
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why should sumatriptan be used with caution in a patient with angina
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How long after the first dose can a second dose sumatriptan be given if migraine H/A has not resolved
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Dose may be repeated once after 2 hours
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How long after the first dose can a second dose sumatriptan be given if migraine H/A has not resolved
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dose may be repeated once after 2 hours
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How long after the first dose can a second dose sumatriptan be given if migraine H/A has not resolved
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dose may be repeated once after 2 hours
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what is the moa of the ergot alkaloids in treating migraines
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causes vasoC of cranial arteries less selectively than triptans by acting as an agonist at various
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give some examples of ergots
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ergotamine; ergonovine
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give some examples of ergots
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ergotamine; ergonovine
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what common side effects of ergotamine
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nausea vomiting diarrhea chest pain toxic levels can cause gangrene
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what common side effects of ergotamine
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nausea vomiting diarrhea chest pain toxic levels can cause gangrene
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why is ergotamine sometimes given with caffeine
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increased gut absorption
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are opioids effective against migraines
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no
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