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38 Cards in this Set

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  • Back
when is lithium used to treat mani
prevention and treatment
does lithium have a narrow therapeutic index
yes
lithium is eliminated renally like what other salt
sodium
what is the moa of lithium
unknown, may decrease camp levels which decreases its activity, may inhibit dephosphorylation
what are the adverse effects of lithium
acne, seizures, visual disturbances, edema, ataxia, diabetes insipidis, hypothyroidism, tremors
lithium adverse effects
acne, seizures, visual disturbances, edema, ataxia, diabetes insipidis, hypothyroidism, tremors
how does lithium cause drug induced diabetes insipidus
uncoupling of the vasopressin V2 receptors in the kidney
uncoupling of the vasopressin V2 receptors in the kidney
how does lithium cause drug induced diabetes insipidus
which drug is used to treat lithium induced nephrogenic diabetes insipidis
amiloride
amiloride
drug used to induce nephrogenic diabetes insipidus
how does lithium cause hypothyroidism?
inhibition of 5'iodinase
how does lithium cause hypothyroidism?
inhibition of 5'iodinase
5'iodinase does what
converts T4 to T3
converts T4 to T3
5'iodinase does what
cardiac anomaly in infants born to a woman on lithium
ebsteins anomaly which is malformation of the tricuspid valve leaflets (partly attached to the fibrous tricuspid valve annulus partly atached to the right ventricular endocardium inferior displacement of the tricuspid valve leaflets
cardiac anomaly in infants born to a woman on lithium
ebsteins anomaly which is malformation of the tricuspid valve leaflets (partly attached to the fibrous tricuspid valve annulus partly atached to the right ventricular endocardium inferior displacement of the tricuspid valve leaflets
cardiac anomaly in infants born to a woman on lithium
ebsteins anomaly which is malformation of the tricuspid valve leaflets (partly attached to the fibrous tricuspid valve annulus partly atached to the right ventricular endocardium inferior displacement of the tricuspid valve leaflets
what other meds may be used to treat manic
carbamezipine, valproic acid, benzodiazepines, gabapentin, topiramite
what other meds may be used to treat manic
carbamezipine, valproic acid, benzodiazepines, gabapentin, topiramite
what antihypertensive med for migrain prophylaxis
propanolol
give an example of the triptan drug classes
sumatriptan, almotriptan, naratriptan rizatriptan zolmitriptan
give an example of the triptan drug classes
sumatriptan, almotriptan, naratriptan rizatriptan zolmitriptan
moa of sumatriptan
5-HT1d receptor agonist which causes vasoC in cranial arteries
moa of sumatriptan
5-HT1d receptor agonist which causes vasoC in cranial arteries
moa of sumatriptan
5-HT1d receptor agonist which causes vasoC in cranial arteries
moa of sumatriptan
5-HT1d receptor agonist which causes vasoC in cranial arteries
why should sumatriptan be used with caution in a patient with angina
can precipitate an anginla attack secondary to vasospasm of coronary arteries
can precipitate an anginla attack secondary to vasospasm of coronary arteries
why should sumatriptan be used with caution in a patient with angina
How long after the first dose can a second dose sumatriptan be given if migraine H/A has not resolved
Dose may be repeated once after 2 hours
How long after the first dose can a second dose sumatriptan be given if migraine H/A has not resolved
dose may be repeated once after 2 hours
How long after the first dose can a second dose sumatriptan be given if migraine H/A has not resolved
dose may be repeated once after 2 hours
what is the moa of the ergot alkaloids in treating migraines
causes vasoC of cranial arteries less selectively than triptans by acting as an agonist at various
give some examples of ergots
ergotamine; ergonovine
give some examples of ergots
ergotamine; ergonovine
what common side effects of ergotamine
nausea vomiting diarrhea chest pain toxic levels can cause gangrene
what common side effects of ergotamine
nausea vomiting diarrhea chest pain toxic levels can cause gangrene
why is ergotamine sometimes given with caffeine
increased gut absorption
are opioids effective against migraines
no