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10 Cards in this Set

  • Front
  • Back
parasite that cause malaria
1. Plasmodium flacoparium (most serious)
2. P. malariae
3. P. vivax
4. P. ovale
malaria hypothesis to explain the persitence of the S allele
malaria is prevalent in the places where the S allele is prevalent because it being a heterozygote (AS) protect indivduals from malaria
conditions where malaria is found
habitats that favor the growth of misquitos
1. warm places with lots of sun
2. have stagnant pools of water
how you get malaria
1. get infected by a female misquito who carries the parasite in its salvia

2. the sporozite goes to your liver and produces merozyotes which cause the liver cell to rupture and enter the blood stream

3. the mereozyotes go to the red blood cells and cause them to rupture

4. cause toxins to enter the body and create flu like symptoms
Reasons for high proportions of people with S allele
1. severity of malaria in the area
2. rate of having sickle cell anemia
Livingstone Hypothesis
1. cutting down forests creates a habitat more suitable misquitos because it increase exposure to sunlight and makes the soil more compact and creates pools of water on the ground b/c of reduced biomass
2. praticing horticulture also increases malaria in the area b/c it cuts down trees
Evidence for Malaria Hypothesis
1. geographical correlation between disturbution of P. falcopamen and S allele

2. Epidemiological: kids w/ AS have lower incidences of malaria

3. biochemical: red blood cells of AS genotype sickle in response to intro of malaria to make cell less habitable for parasite
S allele (q) is a function of:
1. s= selection against the AA genotype for the AS when malaria occurs

2. t= reduction of fittness for the ss genotype compared to AS genotype

3. T= time
which variables should have a tight coorespondence
1. q and s (selection coefficent of AS over AA)

2. q and rainfall
what type of selection goes on for A and S alleles
stabilizing where heterzygote has the advantage