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6 Cards in this Set
- Front
- Back
different combinations of the A and S allele and their phenotypic consquences on the production of hemoglobin
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AA= normal
AS= normal but can sickle undercertain conditions SS= produces sickle cell can be lethal if untreated |
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mutation that causes production of sickle cell
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Hb A- gluamic acid in the 6th position of the beta chain (146 a.a.)
Hb S- valine in the 6th positon of the beta chain |
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Sickle Cell Anemia
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1. causes damage to crain and lung
2. Red blood cells (arethrocides) have characterstic sickle shape 3. hard time getting oxygen around the body b/c sickled cells can't travel through the veins properly |
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mutation-selection balance
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a mutation introduces the new allele into the genome and this allele is preserved through the heterozygote
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Prevalance of S allele
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1. Old world (Greece, India, Turkey)
2. Tropical belt of Africa |
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genetic drift and gene flow in the spread of S allele
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does not have an important effect on the prevalance of S allele
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