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6 Cards in this Set
- Front
- Back
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Tropical sprue
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Probably d/t infection.
Responds to antibiotics. Similar to celiac sprue, but can affect the entire small bowel. |
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Whipple's disease
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Caused by bacterial infection with Tropheryma whippelii (gram +).
PAS (+) foamy macrophages in the intestinal lamina propria and mesenteric nodes. Cardiac symptoms, arthralgias, and neurologic symptoms are common. Most often occurs in older men. |
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Celiac sprue
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Autoantibodies to gluten (gliadin) and tissue transglutaminase.
Gliadin is found in wheat and other grains. Results in blunting of villi, crypt hyperplasia, and lymphocytes in the lamina propria. Decreased absorption primarily takes place in the jejunum. Serum levels of anti-tissue transglutaminase are used for screening. Moderately increased risk of malignancy > T-cell lymphoma. |
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Disaccharidase deficiency
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Most common is lactase deficiency > milk intolerance.
Normal-appearing villi. Osmotic diarrhea. Since lactase is located at the tips of the villi, self-limited lactase deficiency can occur following injury (viral infection) Lactose tolerance test - administration of lactose produces symptoms and glucose does not rise more than 20 mg/dL |
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Abeta-lipoproteinemia
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Decreased synthesis of ApoB leads to an inability to generate chylomicrons, and decreased secretion of cholesterol in VLDLs into the bloodstream.
This causes fat accumulation within enterocytes. Presents in early childhood with malabsorption and neurologic manifestations. |
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Pancreatic insufficiency
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Due to cystic fibrosis, obstructing cancer, and chronic pancreatitis.
Causes malabsorption of fat and fat-soluble vitamins, and therefore increased neutral fat in the stool. Negative D-xylose absorption test |
