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15 Cards in this Set

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CHRONIC INFLAMMATORY Characteristics vs acute next slide
CHRONIC INFLAMMTION
DAYS/YEARS
MACROPHAGES
LYMPHOCYTES
proliferation of blood vessels
Fibrosis and tissue necrosis
Acute
ACUTE INFLAMMATION
MINUTES/DAYS
NEUTROPHILS
increased permeability with
exudation of fluids and plasma proteins
Players of accute inflammation
Players
Vascular
Cellular
Chemical mediators
causes of acute iflammation
INFECTION
Bacteria,viruses,parasites
PHYSICAL:
Trauma, heat or cold, radiation
NECROSIS
Any tissue damage,
IMMUNOLOGICAL
Antigen antibody complexes
CHEMICAL
Poisons, toxins
signs of acute inflammation
Swelling (tumour)
Redness (rubor)
Warmth (calor)
Pain (dolor)
Loss of function
Players of acute infl with examples
The blood vessel endothelium (lining of blood vessel)

The circulating cells: neutrophils,lymphocytes, moncytes, eosinophils, basophils, and platelets.

The connective tissue cells: mast cells, fibroblasts, and resident macrophages.

The extracellular matrix: fibrous proteins, adhesive glycoproteins, proteoglycan and the basement membrane. Important in the healing process

Chemical mediators.
what causes capillaries to leak
histamin
are mast cells in blood?
Mast cells are not in blood; they are in connective tissues.
you mentioned that there are 3 inflammation Events:Vascular events,Cellular events, Mediators;
what are the vascular events?
Initial transient vasoconstriction

Massive vasodilation

Increased vascular permeability: this is howfluid oozes out.

Slowing of blood flow (stasis)

HYPEREMIA
Increased in blood flow

Exudation
why does hyperemia occur?
Due to vasodilation of the precapillary arterioles. note this makes sense, since we are not discussing blood pressure but rather blood flow.
what causes redness and heat?
hyperemia
Hyperemia is mediated by?
histamin, bradykinin and postaglandins
what are the mediators of hyperemia: histamin, bradykinin and postaglandins produced from
Mast cells and basophills
what is swelling caused by?
Where does it take place?
explain the mechanism.
makes sense: exudation.
the mechanism:
Post capillary venules

Pull apart their tight junctions

Together with increased hydrostatic pressure

Vessel permeability increases

Proteins are lost into the interstitial space (Exudation)
oh note that the proteins are lost; and this makes sense because the juntions pull away to make rooms for protienns.
What proteins leak?
Albumin, globulins;
Fibrinogen(if blood vessel is severely damaged) largest molecule