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15 Cards in this Set
- Front
- Back
CHRONIC INFLAMMATORY Characteristics vs acute next slide
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CHRONIC INFLAMMTION
DAYS/YEARS MACROPHAGES LYMPHOCYTES proliferation of blood vessels Fibrosis and tissue necrosis |
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Acute
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ACUTE INFLAMMATION
MINUTES/DAYS NEUTROPHILS increased permeability with exudation of fluids and plasma proteins |
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Players of accute inflammation
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Players
Vascular Cellular Chemical mediators |
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causes of acute iflammation
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INFECTION
Bacteria,viruses,parasites PHYSICAL: Trauma, heat or cold, radiation NECROSIS Any tissue damage, IMMUNOLOGICAL Antigen antibody complexes CHEMICAL Poisons, toxins |
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signs of acute inflammation
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Swelling (tumour)
Redness (rubor) Warmth (calor) Pain (dolor) Loss of function |
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Players of acute infl with examples
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The blood vessel endothelium (lining of blood vessel)
The circulating cells: neutrophils,lymphocytes, moncytes, eosinophils, basophils, and platelets. The connective tissue cells: mast cells, fibroblasts, and resident macrophages. The extracellular matrix: fibrous proteins, adhesive glycoproteins, proteoglycan and the basement membrane. Important in the healing process Chemical mediators. |
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what causes capillaries to leak
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histamin
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are mast cells in blood?
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Mast cells are not in blood; they are in connective tissues.
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you mentioned that there are 3 inflammation Events:Vascular events,Cellular events, Mediators;
what are the vascular events? |
Initial transient vasoconstriction
Massive vasodilation Increased vascular permeability: this is howfluid oozes out. Slowing of blood flow (stasis) HYPEREMIA Increased in blood flow Exudation |
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why does hyperemia occur?
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Due to vasodilation of the precapillary arterioles. note this makes sense, since we are not discussing blood pressure but rather blood flow.
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what causes redness and heat?
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hyperemia
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Hyperemia is mediated by?
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histamin, bradykinin and postaglandins
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what are the mediators of hyperemia: histamin, bradykinin and postaglandins produced from
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Mast cells and basophills
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what is swelling caused by?
Where does it take place? explain the mechanism. |
makes sense: exudation.
the mechanism: Post capillary venules Pull apart their tight junctions Together with increased hydrostatic pressure Vessel permeability increases Proteins are lost into the interstitial space (Exudation) oh note that the proteins are lost; and this makes sense because the juntions pull away to make rooms for protienns. |
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What proteins leak?
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Albumin, globulins;
Fibrinogen(if blood vessel is severely damaged) largest molecule |