Magnesium Sulfate

Front 1

Magnesium Sulfate Classification

Back 1

-Antiaarrhythmic
-Electrolyte

Front 2

Magnesium Sulfate Mecahanism of Action

Back 2

-Second most plentiful intracellular cation. Essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability
-some effects on nervous system similar to those of calcium
-Increased conc in extracellular fluid causes depression of CNS, has direct depressant effect on skeletal muscle
-Low conc in extracellular fluid results in increased acetylcholine release and increased muscle excitability that can produce tetany

Front 3

Magnesium Sulfate Mecahanism of Action--SA Node and effects on blood vessels

Back 3

-slows rate of SA Nodal impulse formation. Higher conc produce cardiac arrest in diastole
-causes vasodilation by direct action on blood vessels

Front 4

Magnesium Sulfate Indications

Back 4

-Polymorphic VT with prolonged QT interval
-Rhythm control of AFib < 48 hours duration

Front 5

Magnesium Sulfate Dosing

Back 5

-Torsades (pulseless): 1 to 2 g
-Torasdes (pulse)or Afib with rapid ventricular response: 1 to 2 g

Front 6

Magnesium Sulfate Precautions

Back 6

-caution in patients recieving digitalis
-Caution in impaired renal function
-caution with preexisting heart blocks

Front 7

Magnesium Sulfate Contraindications

Back 7

-Respiratory depression
-Hypocalcemia
-Hypermagnesemia

Front 8

Magnesium Sulfate Special Considerations

Back 8

-S/S-Hypotension
-Flushing, sweating
-bradycardia, AV block
-Respiratory depression
-Drowsiness, decreasing LOC
-diminished reflexes or muscle weakness, flaccid paralysis
-Antidote = Calcium