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13 Cards in this Set

  • Front
  • Back
kupffer cells
liver, removal of senesent rbcs and debri
splenic macs
spleen ; removal of senescent rbcs and debris
mesangial cell macs
kidneys ; phagocytosis, CONTRACTION and support
microglial cell macs
cns ; ingest degenerated myelin
histiocyte macs
connective tissues, phagocytosis
alveolar macs
lungs ; phagocytosis of inhaled particles
Digeorge syndrome
thymic parathyroid aplasia
CATCH22
C- congenital hrt changes (truncas arteriosus/tetrology of fallot)
A- abnormal facial features
T- thymic aplasia
C- cleft palate
H- hypocaclemia from hypoparathyroidism
22- q deletion
facial feature changes in di george syndrome? lab tests?
- low set ears
- wide-set eyes (hypertelorism)
- micrognathia
- hypocalcemia / lymphopenia
why is this disease caught w/in the first week of life ?
b/c infants suffer from hypocalcemia and suffer from hypocalcemic induce tetany (from hypoparathyroidism)
what pouches are involved?
dysmorphogenesis of pouch 3 and 4 in the thymus
- thymus = third pouch
- parathyroids --> inferior glands from thrid pouch; superior 2 glands from the 4th pouch
thymus
- primarly lymphoid organ responsible for t-cell maturation
- dysfunciton --> decrease in all t-cell populations and thus a defcnt CMI response
- recurrent chronic/fungal/viral infections
how is humoral immunity also affected in these patients?
Th cell cytokines (IL-2,4,5) are important for the maturation/proliferation of B-cells
- humoral immunity deteriorates over time as the maternal antibodies are degraded in the baby (~6months)