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9 Cards in this Set

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Macrolides MOA?
inhibit RNA-dependent protein synthesis by binding to 50s ribosomal subunit.

Bacteriostatic unlike penicillin and cephalosporins that are bactericidal
What are the macrolides?
Erythromycin
Azithromycin
Clarithromycin
erythromycin given how? excreted how? Avoid which form in who?
-IV and oral variability.
-excreted by bile so no adjusting in renal failure unless extreme RF.
-GI upset common
-Avoid estolate in pregnancy cause my lead to fatty liver
-avoid estolate in adults cause cholestatic jaundice, but in children its good.
erythromycin interactions with?
Hepatic cytochrome p450
Increase blood levels of
-theophylline
-warfarin
-cyclosporin
Increases QT interval and arrythmias with
-astemizole

THESE ARE NOT PROBLEMS IN AZITHROMYCIN
erythromycin common uses
-CAP in patients younger then 50
-bordetella pertussis (whooping cough)
-alternative for patients who are allergic to penicillin for GAS pharynigitis or skin infecion. Also for early syphilis.
-campylobacter jejuni (diarrhea)
azithromycin uses
like erythromycin but more active against
-h.influenzae
-shigella
and genitourinary pathogens
-c. trachomatis
-u. urealyticum
-n gonorrheae
azithromycin general
unique cause it sustains high serum tissue levels.
rapidly concentrantes in polymorphonuclear leukocytes and alveolar macrophages.
Z pack allows for one dose regimen.
Approved for those greater then 16 years old. One dose every 24 hours.
No drug-drug interactions.
Category B pregnancy.
clarithromycin DOC for?
mycobacterium avium in AIDS patients

H. pylori at times too.
clarithromycin other uses?
H. pylori and more active against H.influenzae that erythromycin but not as active as azithromycin.

only given orally.
adjust dose in renal failure.
p450 hepatic enzymes. drug-drug
Pregancy category C