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2 Cards in this Set
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Megaloblastic anemia
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caused by impaired DNA synthesis
pernicious anemia Folate deficiency anemia chemotherapeutic agents (methotreaxate, hydroxyurea) |
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Pathogenesis of macrocytic anemia in folate and vit. B12 deficiency anemia
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affects all rapidly dividing cells (RBCs, WBCs, platelets, intestinal epithelium)
delayed nuclear maturation (causes a block in cell division --> large nucleated hematopoietic cells, enlarged cells - megaloblasts) Cellular RNA and protein synthesis continues (cytoplasmic volume continues to expand) |
