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15 Cards in this Set

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Shigella is similar to what other group and how?
They are Biochemically similar to Escherichia.

Both cause diarrhea and/or dysentery
Shig-EEEE
Shigella:

- gram what
- O2 utilizer
- susceptible to
Negative

Facultative anaerobe

Drying
List the shigella species and include the number of serotypes associated with each. x4
S. sonnei (1)

S. flexneri (6)

S. dysenteriae (12)

S. boydii (18)
ShigEEE

my SON from the INDUSTRY will

FLEX his HYPERACTIVE muscles to become a

Descent

Boy
Shigella sonnei:

- location
- prevalence
Industrial world

Sporadic outbreaks
Shigella flexneri:

- location
- prevalence
Developing world

Hyperendemic
What is the most severe species of shigella?

What is its prevalence?

Why is it so dangerous?
S. dysentariae

Endemic and epidemic

Produces exotoxin (Shiga toxin) that leads to more severe infection with systemic signs and symptoms.
Shigella:

- reservoir
- ease/method of transmission
Humans ONLY

Highly communicable
Fecal-oral or hands
Which population group is most at risk for Shigella infections?
Pediatric population
What is the most common form of Shigella that causes gasteroenteritis (shigellosis)?

What is the major symptom?
S. Sonnei

Watery diarrhea
What is a major clinical symptom associated with gastroenteritis (shigellosis) associated with S. dysenteriae?
Tenesmus
How would you diagnose shigella clinically? in the lab?
Hard clinically b/c similar to other GI illnesses

Run stool sample grown on SELECTIVE MEDIA
Treatment of shigella:

- limitation
- Ab therapy
Self-limiting

Empiric with AST
Complications of Shigella. x3
Reiter's syndrome (S. flexneri)

Reactive arthritis

Hemolytic Uremic Syndrome (HUS)
What is the most important method for preventing spread of shigella?
Hand washing
What are the virulence factors for Shigella? x3
LPS

Invasins

Exotoxin (Shiga toxin)
LIE(s)