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21 Cards in this Set
- Front
- Back
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T/F - SLE is just a disease of +ANA, arthralgia, and fatigue.
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False
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What is the population most susceptible to SLE?
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Black females 15-45 y.o.
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List the genetic associations with SLE. x3
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DR2
DR3 C4A deficiency |
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List the clinical symptoms. x11
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Serositis
Oral Ulcers Arthritis Photosensitive rash Blood dyscrasias Renal disorder ANA Immunologic disorder Neurologic disorder Malar rash Discoid rash |
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What type of criteria is associated with the 11 clinical symptoms of SLE for legitimate diagnosis?
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4 of 11 must present serially or simultaneously
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What type of serositis is seen in SLE? x3
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Pericarditis (heart)
Pleuritis (lung) Pertonitis (abdomen) |
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Describe the oral ulcers of SLE. x2
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Painless
Can occur on all mucosal surfaces |
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Is the arthritis seen in SLE erosive?
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Non-erosive
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Is the arthritis seen in SLE similar to RA?
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Clinically indistinguishable
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Describe the criteria of SLE's blood dyscrasia.
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Hemolytic Anemia
WITH Reticulocytosis OR Leukopenia OR Lymphopenia OR Thrombocytopenia |
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Describe SLE's criteria for renal disorder.
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URINE MUST BE STERILE
AND Proteinuria OR Cellular casts OR 10 RBC/HPF |
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T/F - A positive ANA test means the person has SLE.
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False
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Describe SLE's criteria for immunologic disorder.
Describe the specificity/sensitivity of each. |
ANA (sensitive)
Anti-phospholipid antibody Anti-dsDNA antibody (specific) Anti-Sm antibody (specific) |
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Which antibody is associated with kidney/renal disease in lupus?
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Anti-dsDNA antibody
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Which antibody can act as procoagulants?
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Anti-phospholipid antibodies
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Describe SLE's neurologic disorders.
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Psychosis
Seizures |
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SLE's malar rash spares what?
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Nasolabial folds
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Older lesions of discoid rash may do what?
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Possible scar
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How do you treat SLE?
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Symptomatically
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SLE is a prototype for what?
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Human Immune Complex Diseases
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What are the three most common manifestations of SLE in descending order
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1. Arthralgia/myalgia
2. Fatigue 3. Fever |
