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21 Cards in this Set

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T/F - SLE is just a disease of +ANA, arthralgia, and fatigue.
False
What is the population most susceptible to SLE?
Black females 15-45 y.o.
List the genetic associations with SLE. x3
DR2

DR3

C4A deficiency
List the clinical symptoms. x11
Serositis
Oral Ulcers
Arthritis
Photosensitive rash

Blood dyscrasias
Renal disorder
ANA
Immunologic disorder
Neurologic disorder

Malar rash
Discoid rash
What type of criteria is associated with the 11 clinical symptoms of SLE for legitimate diagnosis?
4 of 11 must present serially or simultaneously
What type of serositis is seen in SLE? x3
Pericarditis (heart)

Pleuritis (lung)

Pertonitis (abdomen)
Describe the oral ulcers of SLE. x2
Painless

Can occur on all mucosal surfaces
Is the arthritis seen in SLE erosive?
Non-erosive
Is the arthritis seen in SLE similar to RA?
Clinically indistinguishable
Describe the criteria of SLE's blood dyscrasia.
Hemolytic Anemia

WITH

Reticulocytosis OR

Leukopenia OR

Lymphopenia OR

Thrombocytopenia
Describe SLE's criteria for renal disorder.
URINE MUST BE STERILE

AND

Proteinuria OR

Cellular casts OR

10 RBC/HPF
T/F - A positive ANA test means the person has SLE.
False
Describe SLE's criteria for immunologic disorder.

Describe the specificity/sensitivity of each.
ANA (sensitive)

Anti-phospholipid antibody

Anti-dsDNA antibody (specific)

Anti-Sm antibody (specific)
Which antibody is associated with kidney/renal disease in lupus?
Anti-dsDNA antibody
Which antibody can act as procoagulants?
Anti-phospholipid antibodies
Describe SLE's neurologic disorders.
Psychosis

Seizures
SLE's malar rash spares what?
Nasolabial folds
Older lesions of discoid rash may do what?
Possible scar
How do you treat SLE?
Symptomatically
SLE is a prototype for what?
Human Immune Complex Diseases
What are the three most common manifestations of SLE in descending order
1. Arthralgia/myalgia

2. Fatigue

3. Fever