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9 Cards in this Set
- Front
- Back
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What is the typical culprit of ischemia?
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Atherosclerosis
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What is the typical culprit of hemorrhagic?
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Hypertension and aneurysm
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What are the two strategies for neurological protection?
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1. Improve blood flow
2. Reduce brain energy demand |
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What is thrombolysis?
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IV tissue plasminogen activator (tPA) to increase blood flow
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What are three ways to restore blood flow?
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1. Thrombolysis
2. MERCI retriever (embolectomy) 3. Maintenance of brain perfusion pressure |
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What are four strategies for decreasing energy demand in stroke patients?
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1. Hypothermia (only for kids)
2. Sedation + Anxiolysis + Anticonvulsant 3. Reduce production of action potential (anticonvulsant) 4. Inhibit excitatory synaptic transmission |
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Membrane damage causes what three things?
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1. Damage to mitocondria
2. Breakdown of plasma membrane 3. Lysosome lysis |
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What two things causes protein and DNA damage?
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1. Increased Ca2+ levels
2. Reactive oxygen species |
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What are the three mechanisms of BBB breakdown?
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1. Loss of glucose (primary)
2. Inflammatory response 3. Excitotoxicity |
