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20 Cards in this Set
- Front
- Back
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Describe Polyclonal B cell Activation.
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Molecular mimicry leads to initiation of B-cells to proliferate and secrete IgM without CD4 T cells
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Polyclonoal B cell activation occurs without what?
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CD4 T cell activation
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Polyclonoal B cell activation secretes what?
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IgM - autoimmune antibodies
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How is Type II Hypersensitivity mediated?
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By complements and Fc receptors
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What is the primary cause of tissue injury in Type II Hypersensitivity?
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Anti-tissue antibodies
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In Goodpasture's Disease, autoantibodies bind to what?
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Basememt membrane of Kidney Glomurali and Alveoli of Lungs.
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Goodpasture's Disease is what type of hypersensitivity?
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Type II
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Grave's Disease is what type of hypersensitivity?
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Type II
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In Grave's Disease, autoantibodies bind to what?
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TSH receptors
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In Grave's disease, what occurs due to the binding of receptors? x2
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1. Activates adenylate cyclase
2. Overproduction of thyroid hormones |
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Myasthenia Gravis is an example of what type of hypersensitivity?
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Type II
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In Myasthenia Gravis, autoantibodies bind to what?
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ACh receptors on motor end plates of muscles
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On a molecular basis, what is the damage and from what in Myasthenia Gravis?
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Complement mediated degradation of ACh receptors.
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SLE (Systemic Lupus Erythematosus) is an example of what type of hypersensitivity?
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Type III
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SLE autoantibodies bind to what? x6
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1. DNA
2. Histones 3. Erythrocytes 4. Leukocytes 5. Platelets 6. Clotting Factors |
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Describe the initiation of insulinitis of IDDM.
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Infiltration of CD8 T-cells and activation of macrophages initiate it.
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Describe Islet cell damage via insulinitis in IDDM.
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Insulinitis will further release cytokines that will activate CD 4 T-cells. Together, both CD4 and CD8 T cells destroy via DTH mechanism.
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Multiple Sclerosis is an example of what type of hypersensitivity?
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Type IV
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MS is associated with autoreactive T-cells from where?
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Inflammatory regions along the myelin sheath of nerve fibers.
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What is unique about pathogenic T cells in the CNS?
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More restricted usage of T-cell receptor ALPHA and BETA chains.
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