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20 Cards in this Set

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Describe Polyclonal B cell Activation.
Molecular mimicry leads to initiation of B-cells to proliferate and secrete IgM without CD4 T cells
Polyclonoal B cell activation occurs without what?
CD4 T cell activation
Polyclonoal B cell activation secretes what?
IgM - autoimmune antibodies
How is Type II Hypersensitivity mediated?
By complements and Fc receptors
What is the primary cause of tissue injury in Type II Hypersensitivity?
Anti-tissue antibodies
In Goodpasture's Disease, autoantibodies bind to what?
Basememt membrane of Kidney Glomurali and Alveoli of Lungs.
Goodpasture's Disease is what type of hypersensitivity?
Type II
Grave's Disease is what type of hypersensitivity?
Type II
In Grave's Disease, autoantibodies bind to what?
TSH receptors
In Grave's disease, what occurs due to the binding of receptors? x2
1. Activates adenylate cyclase
2. Overproduction of thyroid hormones
Myasthenia Gravis is an example of what type of hypersensitivity?
Type II
In Myasthenia Gravis, autoantibodies bind to what?
ACh receptors on motor end plates of muscles
On a molecular basis, what is the damage and from what in Myasthenia Gravis?
Complement mediated degradation of ACh receptors.
SLE (Systemic Lupus Erythematosus) is an example of what type of hypersensitivity?
Type III
SLE autoantibodies bind to what? x6
1. DNA
2. Histones
3. Erythrocytes
4. Leukocytes
5. Platelets
6. Clotting Factors
Describe the initiation of insulinitis of IDDM.
Infiltration of CD8 T-cells and activation of macrophages initiate it.
Describe Islet cell damage via insulinitis in IDDM.
Insulinitis will further release cytokines that will activate CD 4 T-cells. Together, both CD4 and CD8 T cells destroy via DTH mechanism.
Multiple Sclerosis is an example of what type of hypersensitivity?
Type IV
MS is associated with autoreactive T-cells from where?
Inflammatory regions along the myelin sheath of nerve fibers.
What is unique about pathogenic T cells in the CNS?
More restricted usage of T-cell receptor ALPHA and BETA chains.