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13 Cards in this Set
- Front
- Back
In terms of CD 62L and CD 44, what phenotypical expression is found on naive T-cells?
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CD 62L - HIGH
CD 44 - LOW |
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In terms of CD 62L and CD 44, what phenotypical expression is found on mature/activated T-cells?
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CD 62L - LOW
CD 44 - HIGH |
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Given a lymphopenic wildtype, what happens when activated/memory CD4 T-cell is administered?
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No colitis
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Given a lymphopenic wildtype, what happens when naive CD4 T-cell is administered?
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Colitis
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In the absense of regulation, naive T-cells will ALWAYS be polarized to what?
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Th1 cells.
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Given a lymphopenic wildtype, what happens when naive T-cells AND activated/memory CD4 T-cells are administered
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No colitis
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Within the activated/memory population of T-cells, what naturally occuring cells exist?
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T regs
(CD4+ CD25+ Foxp3+ T-regulatory cells) |
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What does Tregs secrete that downregulate inflammatory response? x2
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IL 10
TGF beta |
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Tregs regulate inflammation where?
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At the level of the Intestinal mucosa or GALT
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What is the main transcription factor responsible for Treg ability?
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Foxp3
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When are nTregs actively functional?
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At time of thymus export.
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iTregs arise from what?
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Activation of CD4+ CD25- T-cells in the periphery
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What is the mechanism responsible for Oral tolerance?
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Tregs are induced in the Peyer's patches and Mesenteric Lymph Nodes, which secrete IL 10 and TGF beta.
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