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13 Cards in this Set

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In terms of CD 62L and CD 44, what phenotypical expression is found on naive T-cells?
CD 62L - HIGH

CD 44 - LOW
In terms of CD 62L and CD 44, what phenotypical expression is found on mature/activated T-cells?
CD 62L - LOW

CD 44 - HIGH
Given a lymphopenic wildtype, what happens when activated/memory CD4 T-cell is administered?
No colitis
Given a lymphopenic wildtype, what happens when naive CD4 T-cell is administered?
Colitis
In the absense of regulation, naive T-cells will ALWAYS be polarized to what?
Th1 cells.
Given a lymphopenic wildtype, what happens when naive T-cells AND activated/memory CD4 T-cells are administered
No colitis
Within the activated/memory population of T-cells, what naturally occuring cells exist?
T regs

(CD4+ CD25+ Foxp3+ T-regulatory cells)
What does Tregs secrete that downregulate inflammatory response? x2
IL 10

TGF beta
Tregs regulate inflammation where?
At the level of the Intestinal mucosa or GALT
What is the main transcription factor responsible for Treg ability?
Foxp3
When are nTregs actively functional?
At time of thymus export.
iTregs arise from what?
Activation of CD4+ CD25- T-cells in the periphery
What is the mechanism responsible for Oral tolerance?
Tregs are induced in the Peyer's patches and Mesenteric Lymph Nodes, which secrete IL 10 and TGF beta.