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15 Cards in this Set

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Ingesting grapefruit with antihistamines can lead to what?
Fatal Cardiac Arrhythmia
What are the factors affecting drug metabolism? x 9
1. Sex
2. Co-morbidity
3. Age
4. Nutritional status (fasting, starvation)
5. Smoking (EtOH, caffeine)
6. Genetic polymorphism
7. Obesity
8. Other drugs
9. Diet
Rifampin and phenobarbital does what drug metabolism?
Induces drug metabolism.
St. John's Wort does what to drug metabolism?
Induces drug metabolism.
Chronic EtOH and smoking does what to drug metabolism?
Induces drug metabolism
What type of foods would induce drug metabolism?
Cruciferous vegetables, garlic, and citrus.
How does fasting induce drug metabolism?
Induces P4502E1
Cimetidine and ketoconazole does what to drug metabolism?
Inhibits drug metabolism
What does Dong Quai do to drug metabolism?
Inhibits drug metabolism
What type of foods would inhibit drug metabolism?
Grapefruit and garlic
How does fasting inhibit drug metabolism?
Depletes cofactors necessary for metabolism.
Biotransformation is used synonymously with what word when referring to drugs?
Metabolism
Where do drug biotransformation occur?
In the liver
Phase I metabolism usually occurs where?
sER
What are the major reactions of Phase I metabolism?
Hydrolysis

Oxidation

Reduction