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21 Cards in this Set
- Front
- Back
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What are the reactants of the first step?
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Acetyl CoA and Oxaloacetate
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What is the product of the first step?
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Citrate
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What is the enzyme of the first step?
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Citrate Synthase
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What happens to Citrate synthase in the first step of the TCA?
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Undergoes dramatic conformational change upon binding to oxaloacetate (induced fit).
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What are the reactant and product of TCA step 2?
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Citrate becomes Isocitrate
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What intermediate is existent on step 2 of the TCA?
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cis-Aconitate
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What is the enzyme required in Step 2 of the TCA?
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Aconitase
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What are the intermediate substeps of TCA step 2?
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1.) Dehydration of C3 to double bond
2.) Rehydration of C2 and C3 |
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What drives the forward reaction of Isocitrate production?
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Utilization of isocitrate
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Describe the aconitase reaction center.
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It has iron-sulfur reaction center that will pick up water.
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What are the reactants and products of TCA step 3?
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Isocitrate converted to alpha-ketoglutarate and CO2
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What is the enzyme for TCA step 3?
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Isocitrate dehydrogenase
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What does isocitrate dehydrogenase do and what is the resultant molecule not seen as the product?
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Oxidizes isocitrate and results in NADH + H+
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What type of reaction is step 4 of TCA?
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Oxidation of alpha-ketoglutarate
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What are the reactants and products of step 4?
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Alpha-ketoglutarate converts to Succinyl-CoA and CO2
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What is the enzyme for TCA step 4.
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Alpha-ketogluterate dehydrogenase complex
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What type of resulting molecules come out of step 4 in TCA that are not end products?
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NADH + H+
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What are the reactants and products of step 5 in TCA?
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Succinyl-CoA converts to Succinate
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What are the 5 coenzymes needed for step 4 in TCA.
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TPP, lipoic acid, NAD, FAD, and CoA
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What is the enzyme seen in step 5 of TCA?
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Succinyl-CoA synthetase
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What are the resulting molecules seen in step 5 of TCA that are not products?
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CoA and GTP
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