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15 Cards in this Set
- Front
- Back
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Motor Unit
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Consists of motor neuron and all the muscle fibers it innervates
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Motor End plate
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-Specialized region of the sarcolemma
-Highy excitable -Responsible for intiating action potential that propagates across the myofiber causing muscle contraction |
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Neuromuscular junction
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Junction of the axon terminal of a motoneuron with the motor end plate
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What leads to Duchenne Muscular Dystrophy?
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Mutations in Dystrophin
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What does dystrophin do?
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It along with other proteins of the dystrogylcan complex links the actin cytoskeleton to basal mina
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What happens in DMD?
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Link between the actin cytoskeleton and basal mina is lost
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Cardiac Muscle
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Found in heart, forms thick layer called myocardium
-Involuntary -Inherent rythmicity -One central nucleus per fiber -Fibers joined by intercalated disks -Short and branced striated fibers called cardiomyocytes |
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iNTERCALATED DISKS
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-Junction between two cardiac muscle fibers
-Made from two parts lateral part and transerves part |
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What is the lateral part?
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Runs parallel to myofilaments
-form gap junctions |
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What is transerve part?
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runs across fibers as right angles
-have desmoomes (bind cardiac muscle together) have zonula adherens |
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What does zonula adherens do?
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anchors actin myofilaments of terminal sacromeres to plasma membrane
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desmo function
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binds fibers together prevent their separation during contraction cycles
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Smooth Muscle
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found in gi tract, respirarry tract and blood vessels
-non straited fibers, involuntary -mononucleate -no t tubues, communicate via gap junctions |
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What is contracile apparatus of smooth muscle
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extensive array of interweaving thin filaments and thick filaments and intermediate filaments
-contractile unit consist of myosin filaments connecting actin attached to dense body on plasma membrane -dense body resemble z disk in function |
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Tunica media
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made up of smooth muscle cells and elastic tissue
-thicker in arteries than veins |
