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18 Cards in this Set
- Front
- Back
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Most lymphomas are ___-cell lymphomas.
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B-cell
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Which are the low-grade NHL?
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- small lymphocytic
- follicular/small cleaved cell |
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Which are the intermediate-grade NHL?
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- diffuse large cell
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Which are the high-grade NHL?
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- lymphoblastic
- Burkitt's' |
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Cytogenetic abnormality in Mantle Cell Lymphoma:
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t(11;14) with bcl-1 activation
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Cytogenetic abnormality in Follicular lymphoma:
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t(15;17) with bcl-2 activation
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Cytogenetic abnormality in Burkitt's lymphoma:
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t(8;14) with c-myc activation
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Which part of the LN do MALTomas occur?
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outer/marginal zone
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Which lymphomas arise from the light zone of the LN?
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Burkitt's & follicular
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Which lymphoma arises from the dark zone of the LN?
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diffuse large cell
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What do you see in peripheral blood of someone with SLL/CLL?
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lots of cells (small CD5+ B-cells)
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CD38 as prognostic marker:
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CD38- do better than +
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Who gets Mantle Cell Lymphoma?
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Older men ~ 60 yrs
Bad Px, most incurable |
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MALT-type lymphomas can be linked to infection by what bacteria?
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H. pylori (must tx this, or else will allow B-cell proliferation --> lymphoma)
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What are Dx criteria for Multiple Myeloma?
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- 30% plasma cels in marrow
- M-spike (serum or urine) - lytic bone lesions |
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Who tends to get Multiple Myeloma?
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- older (65-70 yrs)
- male - blacks |
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What is the most common NHL?
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diffuse large cell (B-cell)
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What is Mycoses Fungoides?
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- disease of old age
- sun covered areas - T-cells in epidermis (if spill into blood now called Sezary syndrome CLL-T) |
