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18 Cards in this Set

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  • Back
Most lymphomas are ___-cell lymphomas.
B-cell
Which are the low-grade NHL?
- small lymphocytic
- follicular/small cleaved cell
Which are the intermediate-grade NHL?
- diffuse large cell
Which are the high-grade NHL?
- lymphoblastic
- Burkitt's'
Cytogenetic abnormality in Mantle Cell Lymphoma:
t(11;14) with bcl-1 activation
Cytogenetic abnormality in Follicular lymphoma:
t(15;17) with bcl-2 activation
Cytogenetic abnormality in Burkitt's lymphoma:
t(8;14) with c-myc activation
Which part of the LN do MALTomas occur?
outer/marginal zone
Which lymphomas arise from the light zone of the LN?
Burkitt's & follicular
Which lymphoma arises from the dark zone of the LN?
diffuse large cell
What do you see in peripheral blood of someone with SLL/CLL?
lots of cells (small CD5+ B-cells)
CD38 as prognostic marker:
CD38- do better than +
Who gets Mantle Cell Lymphoma?
Older men ~ 60 yrs
Bad Px, most incurable
MALT-type lymphomas can be linked to infection by what bacteria?
H. pylori (must tx this, or else will allow B-cell proliferation --> lymphoma)
What are Dx criteria for Multiple Myeloma?
- 30% plasma cels in marrow
- M-spike (serum or urine)
- lytic bone lesions
Who tends to get Multiple Myeloma?
- older (65-70 yrs)
- male
- blacks
What is the most common NHL?
diffuse large cell (B-cell)
What is Mycoses Fungoides?
- disease of old age
- sun covered areas
- T-cells in epidermis (if spill into blood now called Sezary syndrome CLL-T)