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33 Cards in this Set
- Front
- Back
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What are clues to an ALL diagnosis?
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+ TdT
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What age is affected by ALL?
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< 15 years old
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What cells does ALL involve?
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precursor B-cells
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What cells does T-ALL involve?
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precursor T-cells
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What is a clue for a T-ALL diagnosis?
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thyoma
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What age does T-ALL typically affect?
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< 25 years old
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What are the acute leukemias?
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ALL and AML
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What level of myeloblasts is AML associated with?
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> 30%
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What is the translocation associated with AML M3 type?
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15, 17
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What chronic leukemia is associated with > 65 years of age?
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CLL
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Other than CLL, if the patient is over the age of 65, what could be the diagnosis?
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Hairy cell leukemia
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What is a clue to hairy cell leukemia?
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TRAP +
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How do you treat hairy cell leukemia?
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2CDA
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What mature B-cell cancer is very similar to CLL?
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small lymphocytic lymphoma (SLL)
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What are the 4 mature B-cell lymphomas?
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follicular lymphoma, diffuse large cell, Burkitts lymphoma, mantle cell lymphoma
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What translocation is follicular lymphoma associated with?
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14, 18
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What gene is activated in follicular lymphoma?
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bcl-2- inhibits apoptosis by blocking the bax channel
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Diffuse large cell lymphoma is associated with what?
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EBV and HHV-8
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Burkitt's lymphoma is associated with what translocation?
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8, 14
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WHat is a classic description associated with Burkitt's?
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starry-sky
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What gene is involved with Burkitt's?
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c-myc
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Mantle cell lymphoma is associated with what translocation?
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11, 14
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What are the 3 plasma cell neoplasms?
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multiple myeloma
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What is used to describe multiple myeloma?
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fried egg appearance
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What Ig is high in multiple myeloma?
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IgG
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CML is associated with what chromosome translocation?
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9, 22- philadelphia chromosome
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What is diagnostic of Hodgkin's disease?
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reed-sternberg cells
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What are the 4 types of Hodgkins disease?
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nodular sclerosing, mixed cellularity, lymphocytic predominant, lymphocytic depleted
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What is the most common Hodgkin's disease?
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nodular sclerosing
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What type of cell is seen in nodular sclerosing?
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laclunar cell
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Who is nodular sclerosing more prominent in?
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women > men, primarily young adults
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What type of cells are seen in lymphocyte predominant?
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popcorn cells
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WHat type of cells are seen in mixed cellularity?
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eosinophils and IL5
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