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23 Cards in this Set

  • Front
  • Back
presence of reed sternberg cells indicate what?
hodgkins lymphoma
describe reed sternberg cells
B cell origin, CD30 and CD15 pos. binucleate cell usually surrounded by lymphcytes
describe the organs affected in HL?
localized, single group of nodes, extranodal rare, can have contiguous spread.
common site of lymphadenopathy of HL?
what virus is 50% associated with HL?
describe the distribution of HL
mainly in men, except nodular sclerosing type. bimodal age distribution
a good prognosis in in HL is associated with what?
increase in lymphocyte number and decrease in Reed sternberg cells
what virus is NHL associated with?
HIV (and immunosuppression)
describe the affected organs in NHL
multiple, peripheral nodes. extranodal involvement common.
type of clonal cells in NHL?
mainly B cells excpet those of lymphoblastic T cell origin
T/F: hypergammaglobulinemia is common in NHL?
age incidence for NHL?
20 to 40yos
describe nodular sclerosing type of HL.
65 to 75%, small number of RS cells, many lymphocytes. excellent prognosis. collagen banding and lacunar cells, usually hits young women
describe mixed cellularity hodgkins lymphoma
Many RS cells, more than lymphocytes, intermediate prognosis. 1/4 of NHLs.
describe lymphocyte predominant HL.
few RS cells, many lymphocytes, excellent prognosis, seen in over 35 men
describe lymphocyte depleted HL
RS high relative to the very few lymphocytes. poor prognosis, seen in older males with disseminated disease
are RS cells definitive dx of HL?
they are necessary but not sufficient for a dx, note lacunar cells are variants in nodular sclerosis HL
describe small lymphocytic lymphoma (NHL)
seen in adults, B cells affected, similar to CLL but with focal mass, low grade lymphoma
describe follicular lymphoma (small cleaved cell).
seen in adults, B cells, t(14;18) bcl-2 expression. difficult to cure; indolent course; bcl2 is involved in apoptosis
describe diffuse large cell lymphoma
older adults but 20% in children. mainly B cells, but some mature T cells. aggressive, but 50% curable
describe lymphoblastic lymphoma
usually children, immature T cells affected, commonly presents with ALL and mediastinal mass, very aggresive.
describes burkitt's lymphoma
usually children, B cells, t(8,14) c-myc gene moves next to heavy chain Ig gene. "starry sky" - sheets of lymphocytes with intersperesed macrophages. associated with EBV
describe findings in multiple myeloma
monoclonal plasma cell with fried egg appearance from the marrow. makes lots of IgG and IgA. destructive bone lesions and hypercalcemia, renal insufficiency. susceptability to infection and anemia. primary amyloidoisis seen and punched out lytic bone lesions on Xray. characterized by monoclonal Ig spike (M protein) on serum protein electrophoresis. Ig light chains in urine. blood smear shows RBCs stacked like poker chips