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58 Cards in this Set

  • Front
  • Back

What are bacteria?

Single celled, prokaryotic organisms.

What are plasmids?

Accessory rings of DNA.

Typically bacteria reproduce by _____________, which is what?

Binary fission, A reproduction process resulting in 2 cells that are identical to the original cell.

What are viruses?

Small, nonliving obligate parasites.

How must viruses reproduce?

Inside host cells.

Viruses are acellular, which means what?

They are not composed of cells.

All viruses have a protein coat called a _________ with __________ (RNA or DNA) inside, Some have an _________.

Capsid, nucleic acid, envelope.

What are prions?

Infectious protein particles.

What do prions cause?

Degenerative disease of the nervous system.

What change a prions shape?

Normal proteins.

What is the purpose of the lymphatic system?

Production maintenance and distribution of lymphocytes in the body.

What do lymphatic capillaries do?

Absorb excess tissue fluid and return it to the bloodstream.

What do the lacteals in the small intestine do?

The lacteal in the small intestine absorb fats associated with proteins.

Lymphatic vessels are a one way valve system that carry what?

Lymph.

What is the function of lymphatic vessels?

Return fluid (water, solutes, and cell products) to the bloodstream.

What are the two classifications of lymphatic organs and what organs are contained in those classifications?

Primary: Red bone marrow, Thymus.




Secondary: Lymph nodes, Spleen.

What happens in red bone marrow?

The site of red blood cell production, and some white blood cells.

What is the thymus?

A bilobed gland in the thoracic cavity superior to the heart.

Does ted suck?

Yes.

What are the lymph nodes?

Oval shaped structures found along lymphatic vessels.


Filled with B-cells, T cells, and macrophages.

What is the spleen?

Organ filled with white pulp containing lymphocytes, and red pulp which is involved with filtering blood.

What is the first line of defense of innate immunity?

Physical and chemical barriers to entry.

What is the second line of defense of innate immunity?

Phagocytic white blood cells


Inflammatory response


Protective proteins (complement and interferons)

What is innate immunity?

A first response to infections and serves as the foundation of adaptive immunity.

Innate defenses include:

Barrier defenses


Phagocytosis


Antimicrobial peptides

Innate defenses that are unique to vertebrates:

Natural killer cells


Interferons


Inflammatory response

Barrier defenses include:

Skin


mucous membranes of the respiratory, urinary, and reproductive tracts

Mucus traps and allows for the removal of?

Microbes

The low pH of the skin and digestive system prevent what?

Growth of bacteria.

4 types of phagocytic cells:

Neutrophils- Engulf and destroy pathogens


Macrophages- Found throughout the body


Dendritic cells- Stimulate development of adaptive immunity


Eosinophils- Discharge destructive enzymes

How do natural killer cells regulate abnormal cells?

They release chemicals leading to cell death

What are the 4 symptoms of inflammation?

Redness


Heat


Swelling


Pain

__________ is released by mast cells and causes the capillaries to dilate and become more permeable to phagocytic white blood cells.

Histamine

If neutrophils cannot control the damage, _________will call in more white blood cells including ___________.

Cytokines, macrophages.

What are complement protective proteins?

A group of blood plasma proteins

What do complement protective proteins do?

Bind to mast cells causing them to release histamine




Bind to pathogens to attract phagocytes




Form a membrane attack complex to put holes in some bacteria and viruses

What are interferon protective proteins and what do they do?

Proteins produced by virus-infected cells sent out to warn neighboring healthy cells

What are the two types of B cells?

Plasma cells


Memory cells

__________ cells produce specific antibodies, while __________ are ready to produce antibodies in the future.

Plasma, memory

What are the three kinds of T cells?

Cytotoxic T cells


Helper T cells


Memory T cells

________ T cells kill virus-infected and cancer cells, _________ T cells regulate immunity, and ________ T cells are ready to kill in the future.

Cytotoxic, helper, memory

What are the characteristics of B cells?

Antibody-mediated immunity against pathogens




Produced and mature in bone marrow




Directly recognize antigen and then undergo clonal selection

Each B cell has a unique receptor called a BCR that binds to a specific ________.

Antigen

B cells binding to antigens and cytokines secreted by helper T cells result in what?

Clonal expansion in which the B cell makes copies of itself

What cells are produced from the B cell coping itself?

Plasma cells




Memory cells

After an infection has passed, plasma cells undergo __________ leaving memory cells.

Apoptosis

Antibodies do not kill pathogens, they...

Mark them for destruction

The process of antibodies binding to viral surface proteins preventing infection of a host cell is called what?

Neutralization

What is opsonization?

Antibodies bind to antigens on bacteria creating a target for macrophages or neutrophils, triggering phagocytosis

What is the basic unit that composes antibody molecules?

A Y-shaped protein

The _______ is the constant region that determine the class of antibody, and the ________ are the variable region where specific antigens bind.

Trunk of the Y, ends of the Y

What are the characteristics of T cells?

Produced in bone marrow, matured in thymus




Antigen must be presented in groove of an HLA molecule




Cytotoxic T cells destroy nonself antigen-bearing cells




Helper T cells secrete cytokines that control the immune response

Each T cell has a unique receptor called a _____ that will do what?

TCR, it will recognize a piece of an antigen with the help of an antigen-presenting cell (APC)

What happens once an APC engulfs an antigen?

The antigen is broken down and presented on its surface in association with a membrane protein called an MHC. Then it is presented to a T cell in th elymph node or spleen.

What is immunity?

The ability to combat diseases and cancer

What are the two types of immunity?

Active and passive

What is active immunity?

The individuals body making antibodies against a particular antigen. Happens through immunization and vaccines. Depends on memory B and T cells.

What is passive immunity?

When an individual is given antibodies against a particular antigen. Short lived immunity.