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58 Cards in this Set
- Front
- Back
What are bacteria? |
Single celled, prokaryotic organisms. |
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What are plasmids? |
Accessory rings of DNA. |
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Typically bacteria reproduce by _____________, which is what? |
Binary fission, A reproduction process resulting in 2 cells that are identical to the original cell. |
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What are viruses? |
Small, nonliving obligate parasites. |
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How must viruses reproduce? |
Inside host cells. |
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Viruses are acellular, which means what? |
They are not composed of cells. |
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All viruses have a protein coat called a _________ with __________ (RNA or DNA) inside, Some have an _________. |
Capsid, nucleic acid, envelope. |
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What are prions? |
Infectious protein particles. |
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What do prions cause? |
Degenerative disease of the nervous system. |
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What change a prions shape? |
Normal proteins. |
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What is the purpose of the lymphatic system? |
Production maintenance and distribution of lymphocytes in the body. |
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What do lymphatic capillaries do? |
Absorb excess tissue fluid and return it to the bloodstream. |
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What do the lacteals in the small intestine do? |
The lacteal in the small intestine absorb fats associated with proteins. |
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Lymphatic vessels are a one way valve system that carry what? |
Lymph. |
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What is the function of lymphatic vessels? |
Return fluid (water, solutes, and cell products) to the bloodstream. |
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What are the two classifications of lymphatic organs and what organs are contained in those classifications? |
Primary: Red bone marrow, Thymus. Secondary: Lymph nodes, Spleen. |
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What happens in red bone marrow? |
The site of red blood cell production, and some white blood cells. |
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What is the thymus? |
A bilobed gland in the thoracic cavity superior to the heart. |
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Does ted suck? |
Yes. |
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What are the lymph nodes? |
Oval shaped structures found along lymphatic vessels. Filled with B-cells, T cells, and macrophages. |
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What is the spleen? |
Organ filled with white pulp containing lymphocytes, and red pulp which is involved with filtering blood. |
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What is the first line of defense of innate immunity? |
Physical and chemical barriers to entry. |
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What is the second line of defense of innate immunity? |
Phagocytic white blood cells Inflammatory response Protective proteins (complement and interferons) |
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What is innate immunity? |
A first response to infections and serves as the foundation of adaptive immunity. |
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Innate defenses include: |
Barrier defenses Phagocytosis Antimicrobial peptides |
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Innate defenses that are unique to vertebrates: |
Natural killer cells Interferons Inflammatory response |
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Barrier defenses include: |
Skin mucous membranes of the respiratory, urinary, and reproductive tracts |
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Mucus traps and allows for the removal of? |
Microbes |
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The low pH of the skin and digestive system prevent what? |
Growth of bacteria. |
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4 types of phagocytic cells: |
Neutrophils- Engulf and destroy pathogens Macrophages- Found throughout the body Dendritic cells- Stimulate development of adaptive immunity Eosinophils- Discharge destructive enzymes |
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How do natural killer cells regulate abnormal cells? |
They release chemicals leading to cell death |
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What are the 4 symptoms of inflammation? |
Redness Heat Swelling Pain |
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__________ is released by mast cells and causes the capillaries to dilate and become more permeable to phagocytic white blood cells. |
Histamine |
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If neutrophils cannot control the damage, _________will call in more white blood cells including ___________. |
Cytokines, macrophages. |
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What are complement protective proteins? |
A group of blood plasma proteins |
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What do complement protective proteins do? |
Bind to mast cells causing them to release histamine Bind to pathogens to attract phagocytes Form a membrane attack complex to put holes in some bacteria and viruses |
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What are interferon protective proteins and what do they do? |
Proteins produced by virus-infected cells sent out to warn neighboring healthy cells |
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What are the two types of B cells? |
Plasma cells Memory cells |
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__________ cells produce specific antibodies, while __________ are ready to produce antibodies in the future. |
Plasma, memory |
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What are the three kinds of T cells? |
Cytotoxic T cells Helper T cells Memory T cells |
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________ T cells kill virus-infected and cancer cells, _________ T cells regulate immunity, and ________ T cells are ready to kill in the future. |
Cytotoxic, helper, memory |
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What are the characteristics of B cells? |
Antibody-mediated immunity against pathogens Produced and mature in bone marrow Directly recognize antigen and then undergo clonal selection |
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Each B cell has a unique receptor called a BCR that binds to a specific ________. |
Antigen |
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B cells binding to antigens and cytokines secreted by helper T cells result in what? |
Clonal expansion in which the B cell makes copies of itself |
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What cells are produced from the B cell coping itself? |
Plasma cells Memory cells |
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After an infection has passed, plasma cells undergo __________ leaving memory cells. |
Apoptosis |
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Antibodies do not kill pathogens, they... |
Mark them for destruction |
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The process of antibodies binding to viral surface proteins preventing infection of a host cell is called what? |
Neutralization |
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What is opsonization? |
Antibodies bind to antigens on bacteria creating a target for macrophages or neutrophils, triggering phagocytosis |
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What is the basic unit that composes antibody molecules? |
A Y-shaped protein |
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The _______ is the constant region that determine the class of antibody, and the ________ are the variable region where specific antigens bind. |
Trunk of the Y, ends of the Y |
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What are the characteristics of T cells? |
Produced in bone marrow, matured in thymus Antigen must be presented in groove of an HLA molecule Cytotoxic T cells destroy nonself antigen-bearing cells Helper T cells secrete cytokines that control the immune response |
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Each T cell has a unique receptor called a _____ that will do what? |
TCR, it will recognize a piece of an antigen with the help of an antigen-presenting cell (APC) |
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What happens once an APC engulfs an antigen? |
The antigen is broken down and presented on its surface in association with a membrane protein called an MHC. Then it is presented to a T cell in th elymph node or spleen. |
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What is immunity? |
The ability to combat diseases and cancer |
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What are the two types of immunity? |
Active and passive |
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What is active immunity? |
The individuals body making antibodies against a particular antigen. Happens through immunization and vaccines. Depends on memory B and T cells. |
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What is passive immunity? |
When an individual is given antibodies against a particular antigen. Short lived immunity. |