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11 Cards in this Set

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Lupus is the chronic infammatory disease that affects:
1. Skin
2. Joints
3. Heart
4. Blood
5. Kidneys
Discoid lupus (DLE) occurs in ___% of SLE patients
20%
Drugs that induce Lupus
1. Hydralazine
2. Procainamide
3. Quinidine
4. Isonizide
5. Methydopa
6. Chlorpromazine

(occurs 1mo - 1yr after)
Symptoms of drug induced Lupus
Fever, Rash, Arthritis

(sometimes inflamation around heart)
Hallmark of SLE
development of autoantibodies (IgG) to cellular nuclear components, leading to chronic inflammatory autoimmune disease.
80% develop SLE between
15-45
Autoantibodies against: cell nucleus
ANA
Autoantibodies against: DNA
Anti ds DNA
Autoantibodies against: cytoplasmic components (Ribosomes)
Anti-SM; Anti-Smith
SLE triggering agents
1. UVB
2. Physical Stress
3. Burns, infection, pregnancy, surgery
4. Drug induced
5. Hair dyes
6. Not Viral
Clinical presentation of SLE:
Initial: fatigue, fever, musculoskeletal(srthritis, arthralgia)

Flare-ups then remission